fenfluramine has been researched along with Vomiting in 6 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The involvement of 5-hydroxytryptamine (5-HT) with cisplatin-induced emesis in the ferret was investigated using reserpine, para-chlorophenylalanine and fenfluramine." | 7.67 | Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret. ( Barnes, JM; Barnes, NM; Costall, B; Naylor, RJ; Tattersall, FD, 1988) |
| "The involvement of 5-hydroxytryptamine (5-HT) with cisplatin-induced emesis in the ferret was investigated using reserpine, para-chlorophenylalanine and fenfluramine." | 3.67 | Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret. ( Barnes, JM; Barnes, NM; Costall, B; Naylor, RJ; Tattersall, FD, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costall, B | 3 |
| Naylor, RJ | 3 |
| Tattersall, FD | 3 |
| Domeney, AM | 1 |
| Owera-Atepo, JB | 1 |
| Rudd, JA | 1 |
| Barnes, JM | 1 |
| Barnes, NM | 1 |
| Stunkard, A | 1 |
| Rickels, K | 1 |
| Hesbacher, P | 1 |
| Srimal, RC | 1 |
| Singh, HK | 1 |
| Dhawan, BN | 1 |
| Dykes, MH | 1 |
2 trials available for fenfluramine and Vomiting
| Article | Year |
|---|---|
Fenfluramine in the treatment of obesity.
Topics: Adult; Appetite Depressants; Body Weight; Clinical Trials as Topic; Constipation; Dextroamphetamine; | 1973 |
Evaluation of three anorexiants. Clortermine hydrochloride (voranil), fenfluramine hydrochloride (pondimin), and mazindol (sanorex).
Topics: Adolescent; Adult; Age Factors; Appetite Depressants; Clinical Trials as Topic; Depression; Diet, Re | 1974 |
4 other studies available for fenfluramine and Vomiting
| Article | Year |
|---|---|
The actions of fenfluramine and interaction with 5-HT3 receptor-antagonists to inhibit emesis in the ferret.
Topics: Animals; Antiemetics; Cisplatin; Fenclonine; Fenfluramine; Ferrets; Indoles; Male; Metoclopramide; R | 1990 |
Fluphenazine, ICS 205-930 and dl-fenfluramine differentially antagonise drug-induced emesis in the ferret.
Topics: Animals; Apomorphine; Cisplatin; Copper; Copper Sulfate; Emetics; Female; Fenfluramine; Ferrets; Flu | 1990 |
Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret.
Topics: Animals; Biogenic Monoamines; Brain Chemistry; Carnivora; Caudate Nucleus; Cisplatin; Fenclonine; Fe | 1988 |
Experimental evidence for imipramine like activity of fenfluramine.
Topics: Animals; Avoidance Learning; Blepharoptosis; Blood Pressure; Body Temperature; Cats; Columbidae; Dru | 1970 |