fenfluramine has been researched along with Vertigo in 5 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Vertigo: An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixteen children with benign paroxysmal vertigo (BPV) are presented." | 1.27 | Benign paroxysmal vertigo in childhood. Diagnostic significance of vestibular examination and headache provocation tests. ( Balottin, U; Lanzi, G; Mira, E; Piacentino, G, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mira, E | 2 |
| Piacentino, G | 2 |
| Lanzi, G | 2 |
| Balottin, U | 2 |
| Fazzi, E | 1 |
| Schindler, H | 1 |
| Bielesz, G | 1 |
| Greenwood, MH | 1 |
| Gagnon, MA | 1 |
| Bordeleau, JM | 1 |
| Tétreault, L | 1 |
1 review available for fenfluramine and Vertigo
| Article | Year |
|---|---|
[Side effects associated with prolonged use of fenfluramine].
Topics: Depersonalization; Diarrhea; Fatigue; Fenfluramine; Humans; Libido; Sleep; Substance-Related Disorde | 1973 |
1 trial available for fenfluramine and Vertigo
| Article | Year |
|---|---|
Fenfluramine: study of its central action through its effects on sleep.
Topics: Appetite Depressants; Central Nervous System; Clinical Trials as Topic; Digestive System; Female; Fe | 1969 |
3 other studies available for fenfluramine and Vertigo
| Article | Year |
|---|---|
Benign paroxysmal vertigo in childhood: a migraine equivalent.
Topics: Child; Child, Preschool; Female; Fenfluramine; Histamine; Humans; Male; Migraine Disorders; Nitrogly | 1984 |
Benign paroxysmal vertigo in childhood. Diagnostic significance of vestibular examination and headache provocation tests.
Topics: Child; Child, Preschool; Female; Fenfluramine; Headache; Histamine; Humans; Male; Nitroglycerin; Ver | 1984 |
[Treatment of obesity with fenfluramine].
Topics: Adult; Aged; Blood Pressure; Body Weight; Depression; Drug Evaluation; Female; Fenfluramine; Humans; | 1975 |