fenfluramine has been researched along with Tricuspid Incompetence in 5 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eugène, M | 1 |
| Bruneval, P | 2 |
| Bonnet, N | 1 |
| Attias, D | 1 |
| Noize, P | 1 |
| Sauer, M | 1 |
| Moreau, M | 1 |
| Pathak, A | 1 |
| Bagheri, H | 1 |
| Montastruc, JL | 1 |
| Connolly, HM | 1 |
| Crary, JL | 1 |
| McGoon, MD | 1 |
| Hensrud, DD | 1 |
| Edwards, BS | 1 |
| Edwards, WD | 1 |
| Schaff, HV | 1 |
| Garon, CF | 1 |
| Oury, JH | 1 |
| Duran, CM | 1 |
| Melero Tejedor, JM | 1 |
| Rodríguez Bailón, I | 1 |
| Such Martínez, M | 1 |
| Porras Martín, C | 1 |
| Olalla Mercadé, E | 1 |
| Espinosa Caliani, JS | 1 |
5 other studies available for fenfluramine and Tricuspid Incompetence
| Article | Year |
|---|---|
Benfluorex-induced severe primary tricuspid and mitral regurgitation requiring a double-valve replacement.
Topics: Fenfluramine; Heart Valve Prosthesis Implantation; Humans; Hypolipidemic Agents; Mitral Valve Insuff | 2018 |
Valvular heart disease in a patient taking benfluorex.
Topics: Female; Fenfluramine; Glucose Intolerance; Humans; Middle Aged; Mitral Valve Insufficiency; Tricuspi | 2006 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Drug Combinations; Female; Fenfluramine; He | 1997 |
Virus-like particles in the mitral and tricuspid valves explanted from a patient treated with Fenfluramine-Phentermine.
Topics: Adult; Female; Fenfluramine; Heart Valve Prosthesis Implantation; Humans; Mitral Valve; Mitral Valve | 1999 |
[Valvular regurgitation caused by anorectic agents].
Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Heart Valve Prosthesis Impla | 2000 |