Page last updated: 2024-10-27

fenfluramine and Tremor

fenfluramine has been researched along with Tremor in 3 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hayashi, Y1
Jacob-Vadakot, S1
Dugan, EA1
McBride, S1
Olexa, R1
Simansky, K1
Murray, M1
Shumsky, JS1
Srimal, RC1
Singh, HK1
Dhawan, BN1
Greenwood, MH1

Reviews

1 review available for fenfluramine and Tremor

ArticleYear
[Side effects associated with prolonged use of fenfluramine].
    La Vie medicale au Canada francais, 1973, Volume: 2, Issue:3

    Topics: Depersonalization; Diarrhea; Fatigue; Fenfluramine; Humans; Libido; Sleep; Substance-Related Disorde

1973

Other Studies

2 other studies available for fenfluramine and Tremor

ArticleYear
5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats.
    Experimental neurology, 2010, Volume: 221, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Carbidopa; Cervical Vertebrae; Disease Models, Animal; Dose-Response R

2010
Experimental evidence for imipramine like activity of fenfluramine.
    Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 188, Issue:2

    Topics: Animals; Avoidance Learning; Blepharoptosis; Blood Pressure; Body Temperature; Cats; Columbidae; Dru

1970