fenfluramine has been researched along with Thrombosis in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anorectic agents, such as aminorex and fenfluramine derivatives, have been associated previously with the development of primary pulmonary hypertension." | 7.70 | Complex vascular lesions at autopsy in a patient with phentermine-fenfluramine use and rapidly progressing pulmonary hypertension. ( Fedullo, P; Masliah, E; Strother, J; Yi, ES, 1999) |
| "Anorectic agents, such as aminorex and fenfluramine derivatives, have been associated previously with the development of primary pulmonary hypertension." | 3.70 | Complex vascular lesions at autopsy in a patient with phentermine-fenfluramine use and rapidly progressing pulmonary hypertension. ( Fedullo, P; Masliah, E; Strother, J; Yi, ES, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ennezat, PV | 1 |
| Arnaud-Crozat, E | 1 |
| Guerbaai, RA | 1 |
| Stephanov, O | 1 |
| Marinella, MA | 1 |
| Berrettoni, BA | 1 |
| Strother, J | 1 |
| Fedullo, P | 1 |
| Yi, ES | 1 |
| Masliah, E | 1 |
| Humbert, M | 1 |
| Nunes, H | 1 |
| Sitbon, O | 1 |
| Parent, F | 1 |
| Hervé, P | 1 |
| Simonneau, G | 1 |
1 review available for fenfluramine and Thrombosis
| Article | Year |
|---|---|
Risk factors for pulmonary arterial hypertension.
Topics: Altitude; Aminorex; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Second- | 2001 |
3 other studies available for fenfluramine and Thrombosis
| Article | Year |
|---|---|
Fenfluramine induced mitral stenosis complicated by massive left atrial thrombosis.
Topics: Aged, 80 and over; Female; Fenfluramine; Heart Atria; Humans; Mitral Valve Stenosis; Thrombosis | 2021 |
Digital necrosis associated with dexfenfluramine.
Topics: Adult; Appetite Depressants; Diabetes Mellitus, Type 2; Fenfluramine; Fingers; Humans; Male; Necrosi | 1997 |
Complex vascular lesions at autopsy in a patient with phentermine-fenfluramine use and rapidly progressing pulmonary hypertension.
Topics: Adult; Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Humans; Hypertension, Pulmonary; P | 1999 |