fenfluramine has been researched along with Thiamine Deficiency in 1 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Thiamine Deficiency: A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since dietary thiamine deficiency (TD) in mice is considered as a putative model of WKS, it was used in the present study to investigate the function of serotonergic neurons in this disorder." | 3.74 | Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice. ( Arai, Y; Mitazaki, S; Murata, A; Nakagawasai, O; Niijima, F; Ohba, A; Tadano, T; Tan-No, K; Wakui, K, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakagawasai, O | 1 |
| Murata, A | 1 |
| Arai, Y | 1 |
| Ohba, A | 1 |
| Wakui, K | 1 |
| Mitazaki, S | 1 |
| Niijima, F | 1 |
| Tan-No, K | 1 |
| Tadano, T | 1 |
1 other study available for fenfluramine and Thiamine Deficiency
| Article | Year |
|---|---|
Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice.
Topics: Amphetamines; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleran | 2007 |