fenfluramine has been researched along with Tachyarrhythmia in 5 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine is a substituted phenylethylamine structurally related to amphetamine." | 5.25 | Fenfluramine poisoning. ( Temple, AR; Veltri, JC, 1975) |
| "Excitation, coma, convulsions, tachycardia, mydriasis, nystagmus, and rubeosis of the face were the most important signs." | 1.26 | [Fenfluramin (ponderax) intoxications in children (author's transl)]. ( Krienke, EG; Mühlendahl, KE, 1978) |
| "Fenfluramine is a substituted phenylethylamine structurally related to amphetamine." | 1.25 | Fenfluramine poisoning. ( Temple, AR; Veltri, JC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Genné, D | 1 |
| De Torrenté, A | 1 |
| Humair, L | 1 |
| Mühlendahl, KE | 1 |
| Krienke, EG | 2 |
| Von Mühlendahl, KE | 1 |
| Veltri, JC | 1 |
| Temple, AR | 1 |
| Wolfsdorf, J | 1 |
| Kanarek, KS | 1 |
5 other studies available for fenfluramine and Tachyarrhythmia
| Article | Year |
|---|---|
[Voluntary poisoning with dexfenfluramine (Isomeride)].
Topics: Adolescent; Drug Overdose; Female; Fenfluramine; Humans; Hypertension; Iatrogenic Disease; Poisoning | 1994 |
[Fenfluramin (ponderax) intoxications in children (author's transl)].
Topics: Adolescent; Adrenergic beta-Antagonists; Anticonvulsants; Child, Preschool; Chlorpromazine; Coma; El | 1978 |
Fenfluramine poisoning.
Topics: Adolescent; Adult; Central Nervous System Diseases; Child; Child, Preschool; Female; Fenfluramine; H | 1979 |
Fenfluramine poisoning.
Topics: Adolescent; Arrhythmias, Cardiac; Autopsy; Electrocardiography; Female; Fenfluramine; Heart Arrest; | 1975 |
Fenfluramine overdosage in childhood. Case report.
Topics: Accidents, Home; Child, Preschool; Female; Fenfluramine; Fever; Gastric Lavage; Humans; Poisoning; S | 1972 |