Page last updated: 2024-10-27

fenfluramine and Syndrome

fenfluramine has been researched along with Syndrome in 12 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Syndrome: A characteristic symptom complex.

Research Excerpts

ExcerptRelevanceReference
"This study reports on the long-term results for an initial cohort of patients with Sunflower syndrome who enrolled in an open-label study of low-dose fenfluramine as well as the short-term results of a second cohort."9.69Follow-up to low-dose fenfluramine for Sunflower syndrome: A non-randomized controlled trial. ( Bruno, PL; Dowless, D; Geenen, KR; Patel, S; Thiele, EA, 2023)
"Fenfluramine was administered to 14 outpatient children with the syndrome of autism to determine whether previously produced decreases in blood serotonin concentrations and clinical improvements could be reinstituted."9.05Study of fenfluramine in outpatients with the syndrome of autism. ( Freeman, BJ; Geller, E; Novak, P; Ritvo, ER; Schroth, P; Yokota, A; Yuwiler, A, 1984)
" To do so, components of the serotonin syndrome, as induced by various doses of fenfluramine, were scored both before and after a 15-day subacute regimen with these agents."7.67A comparison of the fenfluramine-induced serotonergic syndrome in rats subacutely treated with either saline or D-amphetamine. ( Hunsinger, RN; Wilson, MC, 1984)
"This study reports on the long-term results for an initial cohort of patients with Sunflower syndrome who enrolled in an open-label study of low-dose fenfluramine as well as the short-term results of a second cohort."5.69Follow-up to low-dose fenfluramine for Sunflower syndrome: A non-randomized controlled trial. ( Bruno, PL; Dowless, D; Geenen, KR; Patel, S; Thiele, EA, 2023)
"Fenfluramine was administered to 14 outpatient children with the syndrome of autism to determine whether previously produced decreases in blood serotonin concentrations and clinical improvements could be reinstituted."5.05Study of fenfluramine in outpatients with the syndrome of autism. ( Freeman, BJ; Geller, E; Novak, P; Ritvo, ER; Schroth, P; Yokota, A; Yuwiler, A, 1984)
" Chronic treatment of rats with D-fenfluramine has been shown to decrease the release of cortisol and fatty acids in response to stress, and to improve insulin sensitivity."4.79Role of glucocorticoids and fatty acids in the impairment of lipid metabolism observed in the metabolic syndrome. ( Brindley, DN, 1995)
" To do so, components of the serotonin syndrome, as induced by various doses of fenfluramine, were scored both before and after a 15-day subacute regimen with these agents."3.67A comparison of the fenfluramine-induced serotonergic syndrome in rats subacutely treated with either saline or D-amphetamine. ( Hunsinger, RN; Wilson, MC, 1984)
"This study evaluated the behavioral elements of three 5-HT-related syndromes (intraperitoneal 5-hydroxytryptophan after intracisternal 5,7-dihydroxytryptamine (DHT), p-chloroamphetamine (PCA), fenfluramine (FF), or combinations of drugs) scored from video-tapes and their relationship to locomotor activity (LMA) photocell recording, regional monoamine concentration and S-1 receptor binding."3.67Serotonin-lesion myoclonic syndromes. II. Analysis of individual syndrome elements, locomotor activity and behavioral correlations. ( Pranzatelli, MR; Snodgrass, SR, 1986)
"The syndrome is characterized by insulin insensitivity and an increased control of metabolism by cortisol."2.38Neuroendocrine regulation and obesity. ( Brindley, DN, 1992)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19905 (41.67)18.7374
1990's6 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Patel, S1
Geenen, KR1
Dowless, D1
Bruno, PL1
Thiele, EA1
Mira, E1
Piacentino, G1
Lanzi, G1
Balottin, U1
Fazzi, E1
Hunsinger, RN1
Wilson, MC1
Ritvo, ER1
Freeman, BJ1
Yuwiler, A1
Geller, E1
Yokota, A1
Schroth, P1
Novak, P1
Després, JP1
Lemieux, S1
Lamarche, B1
Prud'homme, D1
Moorjani, S1
Brun, LD1
Gagné, C1
Lupien, PJ1
Brindley, DN3
Storlien, LH1
Oakes, ND1
Pan, DA1
Kusunoki, M1
Jenkins, AB1
Naito, Y1
Pranzatelli, MR2
Rubin, G1
Snodgrass, SR2

Reviews

5 reviews available for fenfluramine and Syndrome

ArticleYear
The insulin resistance-dyslipidemic syndrome: contribution of visceral obesity and therapeutic implications.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1995, Volume: 19 Suppl 1

    Topics: Adipose Tissue; Cardiovascular Diseases; Fenfluramine; Humans; Hyperlipidemias; Insulin Resistance;

1995
Role of glucocorticoids and fatty acids in the impairment of lipid metabolism observed in the metabolic syndrome.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1995, Volume: 19 Suppl 1

    Topics: Animals; Fatty Acids; Fatty Acids, Nonesterified; Fenfluramine; Glucocorticoids; Humans; Hydrocortis

1995
Mechanisms for the effects of benfluorex on the obese-diabetic-dyslipidemic syndrome.
    Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1

    Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hyperlipidemias; Hypogl

1993
[Neuroleptic malignant syndrome-dopamine-serotonin syndrome--the physiopathology, diagnosis, and therapy].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1997, Volume: 99, Issue:10

    Topics: Animals; Appetite Depressants; Dantrolene; Dopamine D2 Receptor Antagonists; Fenfluramine; Humans; M

1997
Neuroendocrine regulation and obesity.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, Volume: 16 Suppl 3

    Topics: Animals; Diabetes Complications; Endocrine Glands; Fenfluramine; Humans; Hydrocortisone; Hyperlipide

1992

Trials

2 trials available for fenfluramine and Syndrome

ArticleYear
Follow-up to low-dose fenfluramine for Sunflower syndrome: A non-randomized controlled trial.
    Developmental medicine and child neurology, 2023, Volume: 65, Issue:7

    Topics: Anticonvulsants; Epilepsy, Reflex; Fenfluramine; Follow-Up Studies; Helianthus; Humans; Seizures; Sy

2023
Study of fenfluramine in outpatients with the syndrome of autism.
    The Journal of pediatrics, 1984, Volume: 105, Issue:5

    Topics: Adolescent; Autistic Disorder; Body Weight; Child; Child Development; Child, Preschool; Female; Fenf

1984

Other Studies

5 other studies available for fenfluramine and Syndrome

ArticleYear
Benign paroxysmal vertigo in childhood: a migraine equivalent.
    ORL; journal for oto-rhino-laryngology and its related specialties, 1984, Volume: 46, Issue:2

    Topics: Child; Child, Preschool; Female; Fenfluramine; Histamine; Humans; Male; Migraine Disorders; Nitrogly

1984
A comparison of the fenfluramine-induced serotonergic syndrome in rats subacutely treated with either saline or D-amphetamine.
    Pharmacological research communications, 1984, Volume: 16, Issue:6

    Topics: Animals; Behavior, Animal; Dextroamphetamine; Fenfluramine; Male; Rats; Rats, Inbred Strains; Recept

1984
Syndromes of insulin resistance in the rat. Inducement by diet and amelioration with benfluorex.
    Diabetes, 1993, Volume: 42, Issue:3

    Topics: Analysis of Variance; Animals; Diet; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Fe

1993
Serotonin-lesion myoclonic syndromes. I. Neurochemical profile and S-1 receptor binding.
    Brain research, 1986, Jan-29, Volume: 364, Issue:1

    Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Amphetamines; Animals; Biogenic Amines; Brain; Brain C

1986
Serotonin-lesion myoclonic syndromes. II. Analysis of individual syndrome elements, locomotor activity and behavioral correlations.
    Brain research, 1986, Jan-29, Volume: 364, Issue:1

    Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Amphetamines; Animals; Dihydroxytryptamines; Drug Inte

1986