fenfluramine has been researched along with Syncope in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The absence seizures were suppressed by treatment with valproate sodium, which had no effect on the self-induced apneas." | 3.67 | Syncopal attacks compulsively self-induced by Valsalva's maneuver associated with typical absence seizures. A case report. ( Aicardi, J; Gastaut, H; Misès, J, 1988) |
| " Polygraphic recording showed two types of syncope, one induced by prolonged apnea and the other by a prolonged Valsalva maneuver." | 3.67 | Compulsive respiratory stereotypies in children with autistic features: polygraphic recording and treatment with fenfluramine. ( Gastaut, H; Rufo, M; Zifkin, B, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gaul, G | 1 |
| Blazek, G | 1 |
| Deutsch, E | 1 |
| Heeger, H | 1 |
| Aicardi, J | 1 |
| Gastaut, H | 2 |
| Misès, J | 1 |
| Zifkin, B | 1 |
| Rufo, M | 1 |
3 other studies available for fenfluramine and Syncope
| Article | Year |
|---|---|
[A case of chronic pulmonary hypertension after fenfluramine intake].
Topics: Chronic Disease; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Middle Aged; Nifedipine; Obe | 1982 |
Syncopal attacks compulsively self-induced by Valsalva's maneuver associated with typical absence seizures. A case report.
Topics: Apnea; Child; Child Behavior; Compulsive Behavior; Electroencephalography; Epilepsy, Absence; Female | 1988 |
Compulsive respiratory stereotypies in children with autistic features: polygraphic recording and treatment with fenfluramine.
Topics: Apnea; Autistic Disorder; Child; Child, Preschool; Compulsive Behavior; Electrocardiography; Electro | 1987 |