Page last updated: 2024-10-27

fenfluramine and Stroke

fenfluramine has been researched along with Stroke in 1 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Research Excerpts

ExcerptRelevanceReference
"Patients suffering from major depression in the post-stroke period have a blunted prolactin response to D-fenfluramine."9.10Blunted prolactin response to D-fenfluramine in post-stroke major depression. ( Hopwood, M; Maguire, K; Morris, P; Norman, T; Schweitzer, I, 2003)
"Patients suffering from major depression in the post-stroke period have a blunted prolactin response to D-fenfluramine."5.10Blunted prolactin response to D-fenfluramine in post-stroke major depression. ( Hopwood, M; Maguire, K; Morris, P; Norman, T; Schweitzer, I, 2003)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Morris, P1
Hopwood, M1
Maguire, K1
Norman, T1
Schweitzer, I1

Trials

1 trial available for fenfluramine and Stroke

ArticleYear
Blunted prolactin response to D-fenfluramine in post-stroke major depression.
    Journal of affective disorders, 2003, Volume: 76, Issue:1-3

    Topics: Aged; Depressive Disorder; Female; Fenfluramine; Humans; Magnetic Resonance Imaging; Male; Middle Ag

2003