fenfluramine has been researched along with Stroke in 1 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients suffering from major depression in the post-stroke period have a blunted prolactin response to D-fenfluramine." | 9.10 | Blunted prolactin response to D-fenfluramine in post-stroke major depression. ( Hopwood, M; Maguire, K; Morris, P; Norman, T; Schweitzer, I, 2003) |
| "Patients suffering from major depression in the post-stroke period have a blunted prolactin response to D-fenfluramine." | 5.10 | Blunted prolactin response to D-fenfluramine in post-stroke major depression. ( Hopwood, M; Maguire, K; Morris, P; Norman, T; Schweitzer, I, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morris, P | 1 |
| Hopwood, M | 1 |
| Maguire, K | 1 |
| Norman, T | 1 |
| Schweitzer, I | 1 |
1 trial available for fenfluramine and Stroke
| Article | Year |
|---|---|
Blunted prolactin response to D-fenfluramine in post-stroke major depression.
Topics: Aged; Depressive Disorder; Female; Fenfluramine; Humans; Magnetic Resonance Imaging; Male; Middle Ag | 2003 |