fenfluramine has been researched along with Starvation in 11 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Starvation: Lengthy and continuous deprivation of food. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with fenfluramine or fluoxetine increased post-fasting anorexia, abolished the preference for carbohydrates and decreased lipid intake." | 1.29 | Effect of activation of the serotoninergic system during prolonged starvation on subsequent caloric intake and macronutrient selection in the Zucker rat. ( Duhault, J; Espinal, J; Lacour, F; Rolland, Y, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (90.91) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stunkard, AJ | 1 |
| Duhault, J | 1 |
| Lacour, F | 1 |
| Espinal, J | 1 |
| Rolland, Y | 1 |
| Brindley, DN | 1 |
| Dobrzanski, S | 1 |
| Doggett, NS | 1 |
| Wales, JK | 1 |
| Munro, JF | 1 |
| Bendotti, C | 1 |
| Garattini, S | 1 |
| Samanin, R | 1 |
| Court, JM | 1 |
| Broekkamp, CL | 1 |
| Honig, WM | 1 |
| Pauli, AI | 1 |
| Van Rossum, JM | 1 |
| Sulaiman, WR | 1 |
| Johnson, RH | 1 |
| Rennie, MJ | 1 |
2 reviews available for fenfluramine and Starvation
| Article | Year |
|---|---|
Anorectic agents lower a body weight set point.
Topics: Animals; Appetite Depressants; Appetite Regulation; Behavior Therapy; Body Weight; Dextroamphetamine | 1982 |
The management of obesity.
Topics: Adolescent; Adult; Amphetamine; Body Weight; Child; Chlorphentermine; Diet, Reducing; Diethylpropion | 1972 |
1 trial available for fenfluramine and Starvation
| Article | Year |
|---|---|
Blood metabolite changes during fenfluramine therapy compared with partial starvation.
Topics: Acetoacetates; Fatty Acids, Nonesterified; Fenfluramine; Glycerol; Humans; Hydroxybutyrates; Ketone | 1972 |
8 other studies available for fenfluramine and Starvation
| Article | Year |
|---|---|
Effect of activation of the serotoninergic system during prolonged starvation on subsequent caloric intake and macronutrient selection in the Zucker rat.
Topics: Animals; Anorexia; Dietary Carbohydrates; Energy Intake; Fenfluramine; Fluoxetine; Food Preferences; | 1993 |
Some aspects of the physiological and pharmacological control of the synthesis of triacylglycerols and phospholipids.
Topics: Animals; Diabetes Mellitus; Energy Metabolism; Fenfluramine; Humans; Hypolipidemic Agents; Liver; Ob | 1978 |
The effects of (+)-amphetamine and fenfluramine on feeding in starved and satiated mice.
Topics: Amphetamine; Animals; Arousal; Caffeine; Circadian Rhythm; Dose-Response Relationship, Drug; Feeding | 1976 |
The use of fenfluramine in patients undergoing therapeutic starvation.
Topics: Fenfluramine; Humans; Obesity; Starvation | 1975 |
Endocrine and metabolic disease. Obesity.
Topics: Diet, Reducing; Fenfluramine; Humans; Ileum; Jejunum; Mazindol; Obesity; Phenethylamines; Physical E | 1976 |
Eating caused by neuropeptide-Y injection in the paraventricular hypothalamus: response to (+)-fenfluramine and (+)-amphetamine in rats.
Topics: Amphetamine; Animals; Feeding Behavior; Female; Fenfluramine; Hypothalamus; Male; Neuropeptide Y; Ra | 1987 |
Pharmacological suppression of eating behavior in relation to diencephalic noradrenergic receptors.
Topics: Animals; Catheterization; Depression, Chemical; Dextroamphetamine; Diencephalon; Epinephrine; Feedin | 1974 |
The treatment of obesity.
Topics: Adipose Tissue; Amphetamine; Appetite Depressants; Chorionic Gonadotropin; Diet Fads; Diet, Reducing | 1971 |