fenfluramine has been researched along with Smoking Cessation in 6 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Smoking Cessation: Discontinuing the habit of SMOKING.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested whether 14 wk of dexfenfluramine (30 mg) or fluoxetine (40 mg) treatment would prevent weight gain after subjects quit smoking." | 9.08 | Efficacies of dexfenfluramine and fluoxetine in preventing weight gain after smoking cessation. ( el-Khoury, A; Goldberg, H; McDermott, J; Pingitore, R; Spring, B; Wurtman, J; Wurtman, R, 1995) |
| "A long-term, follow-up evaluation was undertaken in subjects who were randomly assigned to receive either fenfluramine hydrochloride (60 mg daily) or placebo as part of a double-blind smoking cessation therapy study." | 5.09 | Echocardiographic examination of women previously treated with fenfluramine: long-term follow-up of a randomized, double-blind, placebo-controlled trial. ( Balady, GJ; Bowen, DJ; Constantine, G; Davidoff, R; Davis, KD; McTiernan, A; Mendes, LA; Rudolph, RE, 2001) |
| "We tested whether 14 wk of dexfenfluramine (30 mg) or fluoxetine (40 mg) treatment would prevent weight gain after subjects quit smoking." | 5.08 | Efficacies of dexfenfluramine and fluoxetine in preventing weight gain after smoking cessation. ( el-Khoury, A; Goldberg, H; McDermott, J; Pingitore, R; Spring, B; Wurtman, J; Wurtman, R, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malone, KM | 1 |
| Waternaux, C | 1 |
| Haas, GL | 1 |
| Cooper, TB | 1 |
| Li, S | 1 |
| Mann, JJ | 1 |
| Spring, B | 2 |
| Wurtman, J | 1 |
| Wurtman, R | 1 |
| el-Khoury, A | 1 |
| Goldberg, H | 1 |
| McDermott, J | 1 |
| Pingitore, R | 2 |
| Rothman, RB | 1 |
| Bowen, DJ | 2 |
| McTiernan, A | 2 |
| Powers, D | 1 |
| Feng, Z | 1 |
| Davidoff, R | 1 |
| Constantine, G | 1 |
| Davis, KD | 1 |
| Balady, GJ | 1 |
| Mendes, LA | 1 |
| Rudolph, RE | 1 |
| Kessler, K | 1 |
1 review available for fenfluramine and Smoking Cessation
| Article | Year |
|---|---|
Strategies to minimize weight gain after smoking cessation: psychological and pharmacological intervention with specific reference to dexfenfluramine.
Topics: Behavior; Fenfluramine; Humans; Serotonin Receptor Agonists; Smoking; Smoking Cessation; Weight Gain | 1992 |
3 trials available for fenfluramine and Smoking Cessation
| Article | Year |
|---|---|
Efficacies of dexfenfluramine and fluoxetine in preventing weight gain after smoking cessation.
Topics: Adult; Analysis of Variance; Appetite Depressants; Body Mass Index; Dietary Carbohydrates; Dietary P | 1995 |
Recruiting women into a smoking cessation program: who might quit?
Topics: Adult; Aged; Double-Blind Method; Female; Fenfluramine; Humans; Middle Aged; Motivation; Northwester | 2000 |
Echocardiographic examination of women previously treated with fenfluramine: long-term follow-up of a randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Body Mass Index; Double-Blind Method; Echocardiography; Female; Fenfluramin | 2001 |
2 other studies available for fenfluramine and Smoking Cessation
| Article | Year |
|---|---|
Cigarette smoking, suicidal behavior, and serotonin function in major psychiatric disorders.
Topics: Adolescent; Adult; Aged; Comorbidity; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortis | 2003 |
Smoking cessation in a patient being treated with fenfluramine plus phentermine for simple obesity.
Topics: Adult; Alcohol Drinking; Comorbidity; Drug Therapy, Combination; Fenfluramine; Humans; Male; Obesity | 1996 |