fenfluramine has been researched along with Sleep Initiation and Maintenance Disorders in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Sleep Initiation and Maintenance Disorders: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ten adult subjects were referred to our sleep disorders center complaining of difficulty in maintaining sleep due to frequent and recurrent awakenings to eat or drink." | 1.29 | Nocturnal eating syndrome in adults. ( Granella, F; Marchesi, C; Melli, I; Parrino, L; Spaggiari, MC; Terzano, MG, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spaggiari, MC | 1 |
| Granella, F | 1 |
| Parrino, L | 1 |
| Marchesi, C | 1 |
| Melli, I | 1 |
| Terzano, MG | 1 |
| Stunkard, A | 1 |
| Rickels, K | 1 |
| Hesbacher, P | 1 |
| Gagnon, MA | 1 |
| Bordeleau, JM | 1 |
| Tétreault, L | 1 |
2 trials available for fenfluramine and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Fenfluramine in the treatment of obesity.
Topics: Adult; Appetite Depressants; Body Weight; Clinical Trials as Topic; Constipation; Dextroamphetamine; | 1973 |
Fenfluramine: study of its central action through its effects on sleep.
Topics: Appetite Depressants; Central Nervous System; Clinical Trials as Topic; Digestive System; Female; Fe | 1969 |
1 other study available for fenfluramine and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Nocturnal eating syndrome in adults.
Topics: Adult; Body Mass Index; Circadian Rhythm; Compulsive Behavior; Dose-Response Relationship, Drug; Dru | 1994 |