fenfluramine has been researched along with Sleep Apnea Syndromes in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Sleep Apnea Syndromes: Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Obesity is a morbid condition with hemodynamic consequences affecting the systemic and pulmonary circulations leading to a risk of pulmonary hypertension." | 2.41 | [Pulmonary hypertension and obesity]. ( Humbert, M; Ioos, V; Parent, F; Simonneau, G; Sitbon, O; Sztrymf, B, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DeMeo, MT | 1 |
| Mobarhan, S | 1 |
| Mikolaitis, S | 1 |
| Kazi, N | 1 |
| Sztrymf, B | 1 |
| Ioos, V | 1 |
| Sitbon, O | 1 |
| Parent, F | 1 |
| Simonneau, G | 1 |
| Humbert, M | 1 |
1 review available for fenfluramine and Sleep Apnea Syndromes
| Article | Year |
|---|---|
[Pulmonary hypertension and obesity].
Topics: Aminorex; Fenfluramine; Hemodynamics; Humans; Hypertension, Pulmonary; Hypothyroidism; Hypoxia; Obes | 2002 |
1 other study available for fenfluramine and Sleep Apnea Syndromes
| Article | Year |
|---|---|
Three cases of comprehensive dietary therapy and pharmacotherapy of patients with complex obesity-related diseases.
Topics: Adult; Aged; Appetite Depressants; Diabetes Mellitus, Type 2; Diet, Reducing; Fatty Liver; Female; F | 1997 |