fenfluramine has been researched along with Sexual Dysfunction, Physiological in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Sexual Dysfunction, Physiological: Physiological disturbances in normal sexual performance in either the male or the female.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Six patients with PME and hypogonadotropic hypogonadism were treated with fenfluramine (20 mg)." | 5.30 | Effects of fenfluramine on ejaculatory function, luteinizing hormone and testosterone levels in men with hypogonadotropic hypogonadism and premature ejaculation. ( Cohen, PG; Holbrook, JM, 1999) |
| "Six patients with PME and hypogonadotropic hypogonadism were treated with fenfluramine (20 mg)." | 1.30 | Effects of fenfluramine on ejaculatory function, luteinizing hormone and testosterone levels in men with hypogonadotropic hypogonadism and premature ejaculation. ( Cohen, PG; Holbrook, JM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, AM | 1 |
| Kumar, M | 1 |
| Lahey, BB | 1 |
| Katz, DA | 1 |
| Fernandez, B | 1 |
| Shaw, JA | 1 |
| Campo, A | 1 |
| Nemeroff, CB | 1 |
| Rosen, RC | 1 |
| Ashton, AK | 1 |
| Cohen, PG | 1 |
| Holbrook, JM | 1 |
1 review available for fenfluramine and Sexual Dysfunction, Physiological
| Article | Year |
|---|---|
Prosexual drugs: empirical status of the "new aphrodisiacs".
Topics: Aphrodisiacs; Bethanechol; Bethanechol Compounds; Dopamine Agents; Female; Fenfluramine; Humans; Mal | 1993 |
2 other studies available for fenfluramine and Sexual Dysfunction, Physiological
| Article | Year |
|---|---|
Marked reduction in serotonergic activity in a sexually aggressive adolescent male.
Topics: Adolescent; Aggression; Analysis of Variance; Carbon Isotopes; Fenfluramine; Humans; Male; Prolactin | 2014 |
Effects of fenfluramine on ejaculatory function, luteinizing hormone and testosterone levels in men with hypogonadotropic hypogonadism and premature ejaculation.
Topics: Adult; Ejaculation; Fenfluramine; Humans; Hypogonadism; Luteinizing Hormone; Male; Middle Aged; Sexu | 1999 |