fenfluramine has been researched along with Seasonal Affective Disorders in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prolactin and cortisol responses to acute challenge with dl-fenfluramine (60 mg PO) were examined in 10 (6 women and 4 men) patients with seasonal affective disorder (SAD) and the same number of age, gender, menstrual status, and season matched healthy controls." | 7.69 | Hormonal responses to dl-fenfluramine challenge are not blunted in seasonal affective disorder. ( Michalon, M; Yatham, LN, 1995) |
| "The effects of the serotonergic agent d,l-fenfluramine (60 mg PO) or a placebo on serum prolactin (PRL) and cortisol levels were evaluated in seven patients (five men and two women) with seasonal affective disorders (SAD) and in eight normal controls (eight men and two women)." | 5.07 | Abnormal serotonergic control of prolactin and cortisol secretion in patients with seasonal affective disorder. ( Caffarra, P; Caffarri, G; Chiodera, P; Coiro, V; Davoli, C; Davolio, M; De Ferri, A; Marchesi, C; Rossi, G; Volpi, R, 1993) |
| "Prolactin and cortisol responses to acute challenge with dl-fenfluramine (60 mg PO) were examined in 10 (6 women and 4 men) patients with seasonal affective disorder (SAD) and the same number of age, gender, menstrual status, and season matched healthy controls." | 3.69 | Hormonal responses to dl-fenfluramine challenge are not blunted in seasonal affective disorder. ( Michalon, M; Yatham, LN, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coiro, V | 1 |
| Volpi, R | 1 |
| Marchesi, C | 1 |
| De Ferri, A | 1 |
| Davoli, C | 1 |
| Caffarra, P | 1 |
| Rossi, G | 1 |
| Caffarri, G | 1 |
| Davolio, M | 1 |
| Chiodera, P | 1 |
| Yatham, LN | 1 |
| Michalon, M | 1 |
1 trial available for fenfluramine and Seasonal Affective Disorders
| Article | Year |
|---|---|
Abnormal serotonergic control of prolactin and cortisol secretion in patients with seasonal affective disorder.
Topics: Adult; Body Weight; Female; Fenfluramine; Humans; Hydrocortisone; Male; Prolactin; Seasonal Affectiv | 1993 |
1 other study available for fenfluramine and Seasonal Affective Disorders
| Article | Year |
|---|---|
Hormonal responses to dl-fenfluramine challenge are not blunted in seasonal affective disorder.
Topics: Adult; Aging; Female; Fenfluramine; Humans; Hydrocortisone; Male; Menstrual Cycle; Middle Aged; Mult | 1995 |