fenfluramine has been researched along with Respiratory Insufficiency in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine is a substituted phenylethylamine structurally related to amphetamine." | 5.25 | Fenfluramine poisoning. ( Temple, AR; Veltri, JC, 1975) |
| "Fenfluramine is a substituted phenylethylamine structurally related to amphetamine." | 1.25 | Fenfluramine poisoning. ( Temple, AR; Veltri, JC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LoVecchio, F | 1 |
| Curry, SC | 1 |
| Veltri, JC | 1 |
| Temple, AR | 1 |
2 other studies available for fenfluramine and Respiratory Insufficiency
| Article | Year |
|---|---|
Dexfenfluramine overdose.
Topics: Adult; Coma; Female; Fenfluramine; Humans; Respiratory Insufficiency; Seizures; Serotonin Agents; Su | 1998 |
Fenfluramine poisoning.
Topics: Adolescent; Arrhythmias, Cardiac; Autopsy; Electrocardiography; Female; Fenfluramine; Heart Arrest; | 1975 |