fenfluramine has been researched along with Recrudescence in 5 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sher, L | 1 |
| Oquendo, MA | 1 |
| Galfalvy, HC | 1 |
| Cooper, TB | 1 |
| Mann, JJ | 1 |
| Douglas, JG | 1 |
| Gough, J | 1 |
| Preston, PG | 1 |
| Frazer, I | 1 |
| Haslett, C | 1 |
| Chalmers, SR | 1 |
| Munro, JF | 1 |
| Williamson, DJ | 1 |
| McTavish, SF | 1 |
| Park, SB | 1 |
| Cowen, PJ | 1 |
| Ost, LG | 1 |
| Götestam, KG | 1 |
| Guy-Grand, B | 1 |
1 review available for fenfluramine and Recrudescence
| Article | Year |
|---|---|
INDEX (international dexfenfluramine study) as a model for long-term pharmacotherapy of obesity in the 1990s.
Topics: Fenfluramine; Humans; Obesity; Recurrence; Time Factors; Weight Loss | 1992 |
3 trials available for fenfluramine and Recrudescence
| Article | Year |
|---|---|
Long-term efficacy of fenfluramine in treatment of obesity.
Topics: Body Weight; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Fen | 1983 |
Effect of valine on 5-HT-mediated prolactin release in healthy volunteers, and on mood in remitted depressed patients.
Topics: Adult; Affect; Aged; Amino Acids, Branched-Chain; Amitriptyline; Antidepressive Agents; Blood-Brain | 1995 |
Behavioral and pharmacological treatments for obesity: an experimental comparison.
Topics: Adolescent; Adult; Behavior Therapy; Evaluation Studies as Topic; Exercise Therapy; Female; Fenflura | 1976 |
1 other study available for fenfluramine and Recrudescence
| Article | Year |
|---|---|
The number of previous depressive episodes is positively associated with cortisol response to fenfluramine administration.
Topics: Adult; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Male; Middle Aged; Psychia | 2004 |