fenfluramine has been researched along with Pyrexia in 11 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine has been shown to provide clinically meaningful and statistically significant reductions in convulsive seizure frequency in children and adolescents (aged 2-18 years) with Dravet syndrome in two randomized, placebo-controlled clinical trials." | 2.94 | Fenfluramine HCl (Fintepla ( Agarwal, A; Farfel, G; Galer, B; Gammaitoni, A; Lagae, L; Lock, M; Morrison, G; Nabbout, R; Polster, T; Pringsheim, M; Scheffer, IE; Sullivan, J; Talwar, D, 2020) |
| "Fenfluramine is an effective antiepileptic drug for pediatric patients with Dravet syndrome, demonstrating clinically meaningful reduction in convulsive frequency, and generally could be well tolerated." | 2.72 | Efficacy and safety of fenfluramine in patients with Dravet syndrome: A meta-analysis. ( Li, W; Wang, C; Zhang, L, 2021) |
| "Two schedules of imipramine (IM) administration were compared, a single intraperitoneal dose (10 mg/kg) (I) and chronic oral dosage (10 mg/kg twice a day for 14 days) (II)." | 1.26 | Different pharmacokinetic and pharmacological effects following acute and chronic treatment with imipramine. ( Daniel, W; Maj, J; Melzacka, M; Mogilnicka, E, 1982) |
| "Haloperidol was ineffective as a fenfluramine antagonist." | 1.26 | Fenfluramine-induced hyperthermia and stimulation in the rabbit. ( Beal, GA; Quock, RM, 1976) |
| "In the development of visual hallucinations somatic and psychic factors are significant." | 1.25 | [The acute visual hallucinosis in infancy. Clinical, neurophysiological and psychodevelopmental aspects and differential typology (author's transl)]. ( Eggers, C, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Sullivan, J | 1 |
| Scheffer, IE | 1 |
| Lagae, L | 1 |
| Nabbout, R | 1 |
| Pringsheim, M | 1 |
| Talwar, D | 1 |
| Polster, T | 1 |
| Galer, B | 1 |
| Lock, M | 1 |
| Agarwal, A | 1 |
| Gammaitoni, A | 1 |
| Morrison, G | 1 |
| Farfel, G | 1 |
| Zhang, L | 1 |
| Li, W | 1 |
| Wang, C | 1 |
| Maj, J | 1 |
| Melzacka, M | 1 |
| Mogilnicka, E | 1 |
| Daniel, W | 1 |
| Malberg, JE | 1 |
| Seiden, LS | 1 |
| Stewart, CW | 1 |
| Slikker, W | 1 |
| Sulpizio, A | 1 |
| Fowler, PJ | 1 |
| Macko, E | 1 |
| Quock, RM | 1 |
| Beal, GA | 1 |
| Eggers, C | 1 |
| Haines, AP | 1 |
| Shoenberg, PJ | 1 |
| Wolfsdorf, J | 1 |
| Kanarek, KS | 1 |
| Jonsson, J | 1 |
| Gunne, LM | 1 |
1 review available for fenfluramine and Pyrexia
| Article | Year |
|---|---|
Efficacy and safety of fenfluramine in patients with Dravet syndrome: A meta-analysis.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Fatigue; Fenfluramine; Fever; Human | 2021 |
1 trial available for fenfluramine and Pyrexia
| Article | Year |
|---|---|
Fenfluramine HCl (Fintepla
Topics: Adolescent; Child; Child, Preschool; Double-Blind Method; Epilepsies, Myoclonic; Female; Fenfluramin | 2020 |
9 other studies available for fenfluramine and Pyrexia
| Article | Year |
|---|---|
Different pharmacokinetic and pharmacological effects following acute and chronic treatment with imipramine.
Topics: Animals; Brain Chemistry; Desipramine; Fenfluramine; Fever; Imipramine; Male; Norepinephrine; Rats; | 1982 |
Administration of fenfluramine at different ambient temperatures produces different core temperature and 5-HT neurotoxicity profiles.
Topics: Animals; Body Temperature Regulation; Brain; Brain Chemistry; Cell Death; Fenfluramine; Fever; Hydro | 1997 |
Hyperthermia-enhanced serotonin (5-HT) depletion resulting from D-fenfluramine (D-Fen) exposure does not evoke a glial-cell response in the central nervous system of rats.
Topics: Animals; Brain Chemistry; Fenfluramine; Fever; Frontal Lobe; Glial Fibrillary Acidic Protein; Gliosi | 1999 |
Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition.
Topics: Animals; Antipsychotic Agents; Body Temperature Regulation; Fenfluramine; Fever; Male; Rats; Recepto | 1978 |
Fenfluramine-induced hyperthermia and stimulation in the rabbit.
Topics: Animals; Behavior, Animal; Body Temperature; Cinanserin; Cyproheptadine; Dose-Response Relationship, | 1976 |
[The acute visual hallucinosis in infancy. Clinical, neurophysiological and psychodevelopmental aspects and differential typology (author's transl)].
Topics: Acute Disease; Age Factors; Atropine; Benzydamine; Biperiden; Cannabis; Child; Child Psychiatry; Chi | 1975 |
Hyperpyrexia and overdose.
Topics: Acidosis; Adult; Female; Fenfluramine; Fever; Humans | 1972 |
Fenfluramine overdosage in childhood. Case report.
Topics: Accidents, Home; Child, Preschool; Female; Fenfluramine; Fever; Gastric Lavage; Humans; Poisoning; S | 1972 |
Interaction of fenfluramine with d-amphetamine-induced excitatory behaviour and hyperthermia.
Topics: Animals; Behavior, Animal; Body Temperature; Brain Chemistry; Dextroamphetamine; Drug Antagonism; Dr | 1972 |