fenfluramine has been researched along with Pulmonary Edema in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Pulmonary Edema: Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clinical observations over the past 15 years incriminated first fenfluramine and recently dexfenfluramine in the provocation of primary pulmonary hypertension." | 3.69 | High altitude may be synergistic with pulmonary hazards of appetite control medications fenfluramine and dexfenfluramine. ( Davis, WM; Waters, IW, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naeije, R | 1 |
| De Backer, D | 1 |
| Vachiéry, JL | 1 |
| De Vuyst, P | 1 |
| Davis, WM | 1 |
| Waters, IW | 1 |
2 other studies available for fenfluramine and Pulmonary Edema
| Article | Year |
|---|---|
High-altitude pulmonary edema with primary pulmonary hypertension.
Topics: Adult; Altitude Sickness; Appetite Depressants; Female; Fenfluramine; Humans; Hypertension, Pulmonar | 1996 |
High altitude may be synergistic with pulmonary hazards of appetite control medications fenfluramine and dexfenfluramine.
Topics: Altitude; Animals; Appetite Depressants; Fenfluramine; Humans; Hypertension, Pulmonary; Lung; Pulmon | 1997 |