fenfluramine has been researched along with Premenstrual Syndrome in 5 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Premenstrual Syndrome: A combination of distressing physical, psychologic, or behavioral changes that occur during the luteal phase of the menstrual cycle. Symptoms of PMS are diverse (such as pain, water-retention, anxiety, cravings, and depression) and they diminish markedly 2 or 3 days after the initiation of menses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ability of d-fenfluramine, a drug that releases brain serotonin and blocks its reuptake, to relieve premenstrual depression and excessive calorie and carbohydrate intakes was examined in 17 women with premenstrual syndrome." | 9.06 | d-Fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression. ( Brzezinski, AA; Gleason, R; Greenfield, J; Nader, T; Wurtman, JJ; Wurtman, RJ, 1990) |
| "The ability of d-fenfluramine, a drug that releases brain serotonin and blocks its reuptake, to relieve premenstrual depression and excessive calorie and carbohydrate intakes was examined in 17 women with premenstrual syndrome." | 5.06 | d-Fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression. ( Brzezinski, AA; Gleason, R; Greenfield, J; Nader, T; Wurtman, JJ; Wurtman, RJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bancroft, J | 1 |
| Cook, A | 1 |
| FitzGerald, M | 1 |
| Malone, KM | 1 |
| Li, S | 1 |
| Harrison, WM | 1 |
| McBride, PA | 1 |
| Endicott, J | 1 |
| Cooper, T | 1 |
| Mann, JJ | 1 |
| Born, MP | 1 |
| Elia, D | 1 |
| Auclair, J | 1 |
| Rey, C | 1 |
| Brzezinski, AA | 1 |
| Wurtman, JJ | 1 |
| Wurtman, RJ | 1 |
| Gleason, R | 1 |
| Greenfield, J | 1 |
| Nader, T | 1 |
2 trials available for fenfluramine and Premenstrual Syndrome
| Article | Year |
|---|---|
Blunted serotonin response to fenfluramine challenge in premenstrual dysphoric disorder.
Topics: Adult; Ambulatory Care; Female; Fenfluramine; Humans; Luteal Phase; Premenstrual Syndrome; Prolactin | 1997 |
d-Fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression.
Topics: Adult; Appetite Regulation; Depression; Dietary Carbohydrates; Energy Intake; Female; Fenfluramine; | 1990 |
3 other studies available for fenfluramine and Premenstrual Syndrome
| Article | Year |
|---|---|
The neuroendocrine response to d-fenfluramine in women with premenstrual depression.
Topics: Adult; Estradiol; Female; Fenfluramine; Humans; Hydrocortisone; Middle Aged; Personality Inventory; | 1995 |
Serotonergic agonist and premenstrual syndrome.
Topics: Female; Fenfluramine; Humans; Methylphenidate; Premenstrual Syndrome; Serotonin | 1992 |
[Efficacy and acceptability of dexfenfluramine in women consulting in gynecology. 336 overweight patients treated for 3 months].
Topics: Adult; Female; Fenfluramine; Genital Diseases, Female; Humans; Menopause; Middle Aged; Obesity; Prem | 1992 |