fenfluramine has been researched along with Pregnancy in 21 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Controlled prospective cohort study comparing 98 women who had taken phentermine/fenfluramine to 233 women who had not, all of whom contacted the California Teratogen Information Service during pregnancy." | 7.71 | Pregnancy outcomes after first trimester exposure to phentermine/fenfluramine. ( Chambers, CD; Dick, LM; Felix, RJ; Johnson, KA; Jones, KL; Kao, KK, 2002) |
| "Controlled prospective cohort study comparing 98 women who had taken phentermine/fenfluramine to 233 women who had not, all of whom contacted the California Teratogen Information Service during pregnancy." | 3.71 | Pregnancy outcomes after first trimester exposure to phentermine/fenfluramine. ( Chambers, CD; Dick, LM; Felix, RJ; Johnson, KA; Jones, KL; Kao, KK, 2002) |
| "Dexfenfluramine (DFEN) was infused SC at doses of either 6 or 12 mg/kg/day during the last week of pregnancy in rats." | 3.68 | Administration of dexfenfluramine in pregnant rats: effect on brain serotonin parameters in offspring. ( Robertson, RM; Rowland, NE, 1992) |
| "Corticosterone levels were increased in methamphetamine-, fenfluramine-, methylenedioxymethamphetamine- and methylphenidate-treated rats relative to levels in saline-treated rats, whereas cocaine-treated rats were unaffected." | 1.33 | Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat. ( Ehrman, LA; Gudelsky, GA; Schaefer, TL; Vorhees, CV; Williams, MT, 2006) |
| "2 times the equivalent human daily dosage according to body surface area." | 1.31 | Impact of antenatal exposure of mice to fenfluramine on cardiac development and long-term growth of the offspring. ( Christensen, HD; Gonzalez, CL; Kupiec, TC; Paulsen, AL; Rayburn, WF; Sienko, AE; Stewart, JD, 2000) |
| "Fenfluramine was intermediate in its effects on reproduction and growth and had behavioral effects that were revealed in tests of preweaning development." | 1.26 | Psychotropic drugs as behavioral teratogens. ( Brunner, RL; Butcher, RE; Vorhees, CV, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 7 (33.33) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Laureano-Melo, R | 1 |
| Dos-Santos, RC | 1 |
| da Conceição, RR | 1 |
| de Souza, JS | 1 |
| da Silva Almeida, C | 1 |
| Reis, LC | 1 |
| Marinho, BG | 1 |
| Giannocco, G | 1 |
| Ahmed, RG | 1 |
| da Silva Côrtes, W | 1 |
| Martin-Gronert, MS | 1 |
| Stocker, CJ | 1 |
| Wargent, ET | 1 |
| Cripps, RL | 1 |
| Garfield, AS | 1 |
| Jovanovic, Z | 1 |
| D'Agostino, G | 1 |
| Yeo, GS | 1 |
| Cawthorne, MA | 1 |
| Arch, JR | 1 |
| Heisler, LK | 1 |
| Ozanne, SE | 1 |
| Lacroix, I | 1 |
| Hurault-Delarue, C | 1 |
| Montastruc, JL | 1 |
| Damase-Michel, C | 1 |
| Morford, LL | 1 |
| Inman-Wood, SL | 1 |
| Gudelsky, GA | 2 |
| Williams, MT | 2 |
| Vorhees, CV | 3 |
| Galineau, L | 1 |
| Belzung, C | 1 |
| Kodas, E | 1 |
| Bodard, S | 1 |
| Guilloteau, D | 1 |
| Chalon, S | 1 |
| Schaefer, TL | 1 |
| Ehrman, LA | 1 |
| Kramer, K | 1 |
| Azmitia, EC | 1 |
| Whitaker-Azmitia, PM | 2 |
| Jahn, GA | 1 |
| Kalia, V | 1 |
| Hole, D | 1 |
| Wilson, CA | 1 |
| Deis, RP | 1 |
| Rayburn, WF | 1 |
| Sienko, AE | 1 |
| Gonzalez, CL | 1 |
| Christensen, HD | 1 |
| Kupiec, TC | 1 |
| Paulsen, AL | 1 |
| Stewart, JD | 1 |
| Humbert, M | 1 |
| Nunes, H | 1 |
| Sitbon, O | 1 |
| Parent, F | 1 |
| Hervé, P | 1 |
| Simonneau, G | 1 |
| Yan, QS | 1 |
| Jones, KL | 1 |
| Johnson, KA | 1 |
| Dick, LM | 1 |
| Felix, RJ | 1 |
| Kao, KK | 1 |
| Chambers, CD | 1 |
| Brunner, RL | 1 |
| Butcher, RE | 1 |
| Scott, ME | 1 |
| Nelson, PG | 1 |
| Atanassoff, PG | 1 |
| Weiss, BM | 1 |
| Schmid, ER | 1 |
| Tornic, M | 1 |
| Rowland, NE | 1 |
| Robertson, RM | 1 |
| Bell, J | 1 |
| Zhang, XN | 1 |
| Gilbert, DL | 1 |
| Franko, BV | 1 |
| Ward, JW | 1 |
| Woodard, G | 1 |
| Courtney, KD | 1 |
| Hooper, AC | 1 |
| Ramírez Soto, E | 1 |
| Delgado Urdapilleta, J | 1 |
1 review available for fenfluramine and Pregnancy
| Article | Year |
|---|---|
Risk factors for pulmonary arterial hypertension.
Topics: Altitude; Aminorex; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Second- | 2001 |
1 trial available for fenfluramine and Pregnancy
| Article | Year |
|---|---|
Comparison of fenfluramine (with ad libitum food intake) with 1,000 calorie diet in obesity.
Topics: Adolescent; Adult; Aged; Diet, Reducing; Evaluation Studies as Topic; Female; Fenfluramine; Humans; | 1972 |
19 other studies available for fenfluramine and Pregnancy
| Article | Year |
|---|---|
Neonatal D-fenfluramine treatment promotes long-term behavioral changes in adult mice.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Dogs; Female; Fenfluramine; Male; | 2022 |
Benfluorex: in utero exposure.
Topics: Abnormalities, Drug-Induced; Appetite Depressants; Female; Fenfluramine; Humans; Organogenesis; Preg | 2013 |
5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.
Topics: Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; Body Weight; Dietary Proteins; Feeding B | 2016 |
Can benfluorex induce congenital malformations?
Topics: Animals; Appetite Depressants; Female; Fenfluramine; France; Heart Defects, Congenital; Humans; Mice | 2012 |
Impaired spatial and sequential learning in rats treated neonatally with D-fenfluramine.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Dose-Response Relationship, Drug; Female; | 2002 |
Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Adrenergic Uptake Inhibitors; Age Fac | 2005 |
Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat.
Topics: 3,4-Methylenedioxyamphetamine; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Bi | 2006 |
In vitro release of [3H]5-hydroxytryptamine from fetal and maternal brain by drugs of abuse.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Brain Chemistry; Cocaine; Designer Drugs; Female; Fen | 1994 |
Receptors and neurotransmitters involved in the dual modulation of prolactin release by the serotoninergic system in pregnant and lactating rats.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Adrenergi | 1999 |
Impact of antenatal exposure of mice to fenfluramine on cardiac development and long-term growth of the offspring.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Aortic Valve; Body Weight; Brain; Dexfenflur | 2000 |
Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.
Topics: Animals; Animals, Newborn; Citalopram; Cocaine; Cocaine-Related Disorders; Electric Stimulation; Fem | 2002 |
Pregnancy outcomes after first trimester exposure to phentermine/fenfluramine.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Appetite Depressants; Cohort Studies; Drug Thera | 2002 |
Psychotropic drugs as behavioral teratogens.
Topics: Animals; Behavior, Animal; Brain Chemistry; Dextropropoxyphene; Disease Models, Animal; Female; Fenf | 1979 |
Fenfluramine in the treatment of hypertensive patients with refractory obesity.
Topics: Female; Fenfluramine; Humans; Hypertension; Male; Middle Aged; Obesity; Placebos; Pregnancy | 1975 |
Pulmonary hypertension and dexfenfluramine.
Topics: Adult; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Pregnancy; Pregnancy Complications, Ca | 1992 |
Administration of dexfenfluramine in pregnant rats: effect on brain serotonin parameters in offspring.
Topics: Animals; Animals, Newborn; Birth Weight; Body Weight; Brain Chemistry; Female; Fenfluramine; Pregnan | 1992 |
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycem | 1992 |
Toxicologic studies of fenfluramine.
Topics: Animals; Cats; Dogs; Female; Fenfluramine; Guinea Pigs; Haplorhini; Lethal Dose 50; Male; Mice; Orga | 1971 |
[Fenfluramine. Anorexigenic drug in obstetrical practice].
Topics: Adult; Animals; Appetite Depressants; Dogs; Female; Fenfluramine; Fluorine; Gestational Age; Humans; | 1969 |