fenfluramine has been researched along with Poisoning in 13 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Poisoning: Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine is a substituted phenylethylamine structurally related to amphetamine." | 5.25 | Fenfluramine poisoning. ( Temple, AR; Veltri, JC, 1975) |
| " Although some volunteer studies have shown substantial decreases in the bioavailability of ingested drugs, no controlled clinical trials have been performed and there is no conclusive evidence that WBI improves the outcome of the poisoned patient." | 2.40 | Position statement: whole bowel irrigation. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. ( Tenenbein, M, 1997) |
| "In the development of visual hallucinations somatic and psychic factors are significant." | 1.25 | [The acute visual hallucinosis in infancy. Clinical, neurophysiological and psychodevelopmental aspects and differential typology (author's transl)]. ( Eggers, C, 1975) |
| "Fenfluramine is a substituted phenylethylamine structurally related to amphetamine." | 1.25 | Fenfluramine poisoning. ( Temple, AR; Veltri, JC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (69.23) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Y | 1 |
| Genné, D | 1 |
| De Torrenté, A | 1 |
| Humair, L | 1 |
| Melandri, R | 1 |
| Re, G | 1 |
| Morigi, A | 1 |
| Lanzarini, C | 1 |
| Vaona, I | 1 |
| Miglioli, M | 1 |
| Tenenbein, M | 1 |
| Eggers, C | 1 |
| Nieminen, L | 1 |
| Möttönen, M | 1 |
| Arvela, P | 1 |
| Veltri, JC | 1 |
| Temple, AR | 1 |
| Gold, RG | 1 |
| Gordon, HE | 1 |
| Da Costa, RW | 1 |
| Porteous, IB | 1 |
| Kimber, KJ | 1 |
| Campbell, DB | 1 |
| Moore, BW | 1 |
| Matthew, H | 1 |
| Locket, S | 1 |
| Darmady, JM | 1 |
| Wolfsdorf, J | 1 |
| Kanarek, KS | 1 |
1 review available for fenfluramine and Poisoning
| Article | Year |
|---|---|
Position statement: whole bowel irrigation. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Arsenic Poisoning; Child; Child, Preschool; Coc | 1997 |
12 other studies available for fenfluramine and Poisoning
| Article | Year |
|---|---|
[Determination of fenfluramine in corpse using GC/NPD and GC/MS].
Topics: Adult; Chromatography, Gas; Fenfluramine; Gas Chromatography-Mass Spectrometry; Humans; Kidney; Live | 2000 |
[Voluntary poisoning with dexfenfluramine (Isomeride)].
Topics: Adolescent; Drug Overdose; Female; Fenfluramine; Humans; Hypertension; Iatrogenic Disease; Poisoning | 1994 |
Whole bowel irrigation after delayed release fenfluramine overdose.
Topics: Adult; Delayed-Action Preparations; Electrocardiography; Female; Fenfluramine; Humans; Intestines; P | 1995 |
[The acute visual hallucinosis in infancy. Clinical, neurophysiological and psychodevelopmental aspects and differential typology (author's transl)].
Topics: Acute Disease; Age Factors; Atropine; Benzydamine; Biperiden; Cannabis; Child; Child Psychiatry; Chi | 1975 |
The effect of cold and diazepam on the toxicity of fenfluramine in mice.
Topics: Animals; Cold Temperature; Diazepam; Dose-Response Relationship, Drug; Fenfluramine; Male; Mice; Mod | 1975 |
Fenfluramine poisoning.
Topics: Adolescent; Arrhythmias, Cardiac; Autopsy; Electrocardiography; Female; Fenfluramine; Heart Arrest; | 1975 |
Fenfluramine overdosage.
Topics: Appetite Depressants; Autopsy; Child; Child, Preschool; Female; Fenfluramine; Fluorine; Heart; Human | 1969 |
Fenfluramine overdosage.
Topics: Appetite Depressants; Child, Preschool; Chromatography, Gas; Female; Fenfluramine; Fluorine; Humans; | 1969 |
Fenfluramine overdosage.
Topics: Adolescent; Appetite Depressants; Diuresis; Fenfluramine; Fluorine; Humans; Phenethylamines; Poisoni | 1970 |
Clinical toxicology. VII. Poisoning by salicylates, paracetamol, tricyclic antidepressants and a miscellany of drugs.
Topics: Acetaminophen; Adult; Amphetamine; Antidepressive Agents; Caustics; Digitalis; Fenfluramine; Humans; | 1973 |
Diazepam for fenfluramine intoxication.
Topics: Child, Preschool; Diazepam; Female; Fenfluramine; Humans; Infusions, Parenteral; Liver; Male; Poison | 1974 |
Fenfluramine overdosage in childhood. Case report.
Topics: Accidents, Home; Child, Preschool; Female; Fenfluramine; Fever; Gastric Lavage; Humans; Poisoning; S | 1972 |