fenfluramine has been researched along with Panic Attacks in 12 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether the 5-HT releasing agent d-fenfluramine (dFEN) has different effects on resting and panic anxiety in panic disorder." | 9.09 | d-Fenfluramine in panic disorder: a dual role for 5-hydroxytryptamine. ( Anderson, IM; Mortimore, C, 2000) |
| " Prolactin and cortisol responses to d-fenfluramine were measured in 16 patients with DSM-III-R panic disorder and 14 normal controls." | 7.69 | Serotonergic function in panic disorder: endocrine responses to D-fenfluramine. ( Apostolopoulos, M; Burrows, GD; Judd, FK; Norman, TR, 1994) |
| "D-Fenfluramine is a medication that induces neuronal release of serotonin." | 5.31 | Increased left posterior parietal-temporal cortex activation after D-fenfluramine in women with panic disorder. ( Brown, GM; Houle, S; Kennedy, SH; Meyer, JH; Swinson, R, 2000) |
| "To investigate whether the 5-HT releasing agent d-fenfluramine (dFEN) has different effects on resting and panic anxiety in panic disorder." | 5.09 | d-Fenfluramine in panic disorder: a dual role for 5-hydroxytryptamine. ( Anderson, IM; Mortimore, C, 2000) |
| " Challenge studies have demonstrated that subjects with social anxiety disorder have a sensitivity to carbon dioxide, cholecystokinin, and caffeine somewhere between that of panic disorder patients and normal controls." | 4.80 | Brain mechanisms of social anxiety disorder. ( Bell, CJ; Malizia, AL; Nutt, DJ, 1998) |
| " Prolactin and cortisol responses to d-fenfluramine were measured in 16 patients with DSM-III-R panic disorder and 14 normal controls." | 3.69 | Serotonergic function in panic disorder: endocrine responses to D-fenfluramine. ( Apostolopoulos, M; Burrows, GD; Judd, FK; Norman, TR, 1994) |
| "Secretion curves for prolactin, cortisol, TSH, and GH from a 37-year old woman with dysthymia and panic disorder with agoraphobia were determined one day prior to (day I), and during a panic attack (day II) associated with an oral dose of 60 mg dl-fenfluramine, a drug known to increase anticipatory anxiety." | 3.69 | Hormonal response during a fenfluramine-associated panic attack. ( Gentil, V; Ramos, RT; Vieira, AH, 1997) |
| "The present study assessed the relation of cortisol response to anxiogenic reactivity during intravenous lactate infusion and oral fenfluramine in 12 panic disorder (PD) patients who responded positively to both challenges and in eight non-reactive control subjects." | 3.68 | Cortisol response during different anxiogenic challenges in panic disorder patients. ( Targum, SD, 1992) |
| "D-Fenfluramine is a medication that induces neuronal release of serotonin." | 1.31 | Increased left posterior parietal-temporal cortex activation after D-fenfluramine in women with panic disorder. ( Brown, GM; Houle, S; Kennedy, SH; Meyer, JH; Swinson, R, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (66.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bernik, M | 1 |
| Ramos, RT | 2 |
| Hetem, LAB | 1 |
| Graeff, F | 1 |
| Federici, LM | 1 |
| Caliman, IF | 1 |
| Fitz, SD | 1 |
| Shekhar, A | 1 |
| Johnson, PL | 1 |
| Solyom, L | 1 |
| Judd, FK | 2 |
| Apostolopoulos, M | 2 |
| Burrows, GD | 2 |
| Norman, TR | 2 |
| Hetem, LA | 1 |
| Vieira, AH | 1 |
| Gentil, V | 1 |
| Stahl, SM | 1 |
| Nutt, DJ | 1 |
| Bell, CJ | 1 |
| Malizia, AL | 1 |
| Meyer, JH | 1 |
| Swinson, R | 1 |
| Kennedy, SH | 1 |
| Houle, S | 1 |
| Brown, GM | 1 |
| Mortimore, C | 1 |
| Anderson, IM | 1 |
| Targum, SD | 1 |
1 review available for fenfluramine and Panic Attacks
| Article | Year |
|---|---|
Brain mechanisms of social anxiety disorder.
Topics: Animals; Brain; Caffeine; Carbon Dioxide; Cholecystokinin; Dopamine; Fear; Fenfluramine; Humans; Pan | 1998 |
2 trials available for fenfluramine and Panic Attacks
| Article | Year |
|---|---|
Effect of single doses of pindolol and d-fenfluramine on flumazenil-induced anxiety in panic disorder patients.
Topics: Adult; Anxiety; Female; Fenfluramine; Flumazenil; GABA Modulators; Humans; Male; Middle Aged; Panic | 2019 |
d-Fenfluramine in panic disorder: a dual role for 5-hydroxytryptamine.
Topics: Adult; Analysis of Variance; Anxiety; Carbon Dioxide; Cross-Over Studies; Double-Blind Method; Femal | 2000 |
9 other studies available for fenfluramine and Panic Attacks
| Article | Year |
|---|---|
Select panicogenic drugs and stimuli induce consistent increases in tail skin flushes and decreases in core body temperature.
Topics: Animals; Body Temperature; Body Temperature Regulation; Carbolines; Fenfluramine; Male; Models, Anim | 2019 |
Controlling panic attacks with fenfluramine.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Bulimia; Depressive Disorder; Female; Fenfluramine; | 1994 |
Serotonergic function in panic disorder: endocrine responses to D-fenfluramine.
Topics: Adult; Female; Fenfluramine; Hormones; Humans; Hydrocortisone; Male; Panic Disorder; Prolactin; Psyc | 1994 |
Prolactin response to dl-fenfluramine in panic disorder.
Topics: Administration, Oral; Adult; Female; Fenfluramine; Humans; Male; Middle Aged; Panic Disorder; Prolac | 1993 |
Addition of d-fenfluramine to benzodiazepines produces a marked improvement in refractory panic disorder--a case report.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Clonazepam; Drug Resistance; Female; Fenfluramine; Humans; P | 1996 |
Hormonal response during a fenfluramine-associated panic attack.
Topics: Adult; Female; Fenfluramine; Hormones; Human Growth Hormone; Humans; Panic Disorder; Prolactin; Sero | 1997 |
Serotonin: it's possible to have too much of a good thing.
Topics: Bulimia; Depressive Disorder; Fenfluramine; Heart Valve Diseases; Humans; Obsessive-Compulsive Disor | 1997 |
Increased left posterior parietal-temporal cortex activation after D-fenfluramine in women with panic disorder.
Topics: Adolescent; Adult; Case-Control Studies; Cerebrovascular Circulation; Dominance, Cerebral; Female; F | 2000 |
Cortisol response during different anxiogenic challenges in panic disorder patients.
Topics: Administration, Oral; Adult; Anxiety Disorders; Arousal; Female; Fenfluramine; Humans; Hydrocortison | 1992 |