fenfluramine has been researched along with Obesity, Morbid in 15 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Obesity, Morbid: The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to assess the efficacy of the appetite suppressant d-fenfluramine in the treatment of binge eating disorder." | 9.08 | d-fenfluramine treatment of binge eating disorder. ( Berkowitz, R; Reiss, E; Stunkard, A; Tanrikut, C; Young, L, 1996) |
| "The purpose of this study was to assess the efficacy of the appetite suppressant d-fenfluramine in the treatment of binge eating disorder." | 5.08 | d-fenfluramine treatment of binge eating disorder. ( Berkowitz, R; Reiss, E; Stunkard, A; Tanrikut, C; Young, L, 1996) |
| " We have evaluated the weight loss of a selective inhibitor of serotonin uptake, fluoxetine, alone as compared with combined therapeutic trial with another serotoninergic drug, dexfenfluramine." | 5.08 | The addition of dexfenfluramine to fluoxetine in the treatment of obesity: a randomized clinical trial. ( Halpern, A; Lima, N; Medeiros-Neto, G; Pedrinola, F; Sztejnsznajd, C, 1996) |
| " The USA, the European Union and Norway have approved orlistat, a pancreatic lipase inhibitor for weight reduction for up to two years." | 4.80 | [The obesity epidemics--do diet pills have a place in the treatment?]. ( Birkeland, KI; Tonstad, S, 2000) |
| " Three hours after dosing on day 3 they ate either a high carbohydrate (63 percent of total energy) or high protein (54 percent) lunchtime meal (the caloric load)." | 2.67 | Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges. ( Blundell, JE; Hill, AJ, 1990) |
| "Drug treatment of obesity offer a possible adjunct, but it may only have modest results, limited by side effects; furthermore, the weight lowering effects last only as long as the drug is being taken and, unfortunately, as soon as the administration is stopped, the weight is regained." | 2.48 | [The pharmacological treatment of obesity: past, present and future]. ( Bedros, JR; Medvegy, M; Pados, G; Simonyi, G, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 12 (80.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Simonyi, G | 1 |
| Pados, G | 1 |
| Medvegy, M | 1 |
| Bedros, JR | 1 |
| Recasens, MA | 1 |
| Barenys, M | 1 |
| Sola, R | 1 |
| Blanch, S | 1 |
| Masana, L | 1 |
| Salas-Salvadó, J | 1 |
| Mathus-Vliegen, EM | 1 |
| Stunkard, A | 1 |
| Berkowitz, R | 1 |
| Tanrikut, C | 1 |
| Reiss, E | 1 |
| Young, L | 1 |
| Pedrinola, F | 1 |
| Sztejnsznajd, C | 1 |
| Lima, N | 1 |
| Halpern, A | 1 |
| Medeiros-Neto, G | 1 |
| Raison, CL | 1 |
| Klein, HM | 1 |
| Deitel, M | 1 |
| Voznesenskaia, TG | 1 |
| Filatova, EG | 1 |
| Solov'eva, AD | 1 |
| Torretta, LK | 1 |
| Jones, L | 1 |
| Tonstad, S | 1 |
| Birkeland, KI | 1 |
| Munro, JF | 1 |
| Cantley, P | 1 |
| Hill, AJ | 1 |
| Blundell, JE | 1 |
| Finer, N | 1 |
| Finer, S | 1 |
| Naoumova, RP | 1 |
5 reviews available for fenfluramine and Obesity, Morbid
| Article | Year |
|---|---|
[The pharmacological treatment of obesity: past, present and future].
Topics: Amides; Anti-Obesity Agents; Anticonvulsants; Antidepressive Agents; Basal Metabolism; Benzazepines; | 2012 |
Dexfenfluramine, fenfluramine, and phentermine for the treatment of morbid obesity.
Topics: Appetite Depressants; Fenfluramine; Humans; Obesity, Morbid; Patient Selection; Phentermine | 1997 |
[The obesity epidemics--do diet pills have a place in the treatment?].
Topics: Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Fenfluramine; Humans; Lactones; Leptin; Obe | 2000 |
The management of obesity. One view.
Topics: Diet, Reducing; Fenfluramine; Food Deprivation; Humans; Jejunoileal Bypass; Obesity; Obesity, Morbid | 1992 |
Dexfenfluramine.
Topics: Fenfluramine; Humans; Obesity, Morbid; United Kingdom | 1991 |
5 trials available for fenfluramine and Obesity, Morbid
| Article | Year |
|---|---|
Effect of dexfenfluramine on energy expenditure in obese patients on a very-low-calorie-diet.
Topics: Adult; Body Composition; Diet, Reducing; Double-Blind Method; Energy Intake; Energy Metabolism; Fema | 1995 |
Prolonged surveillance of dexfenfluramine in severe obesity.
Topics: Adult; Body Weight; Double-Blind Method; Female; Fenfluramine; Follow-Up Studies; Humans; Male; Obes | 1993 |
d-fenfluramine treatment of binge eating disorder.
Topics: Appetite Depressants; Body Mass Index; Bulimia; Double-Blind Method; Female; Fenfluramine; Follow-Up | 1996 |
The addition of dexfenfluramine to fluoxetine in the treatment of obesity: a randomized clinical trial.
Topics: Adult; Aged; Body Mass Index; Drug Therapy, Combination; Female; Fenfluramine; Fluoxetine; Humans; L | 1996 |
Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges.
Topics: Adult; Appetite Regulation; Clinical Trials as Topic; Dietary Carbohydrates; Dietary Proteins; Doubl | 1990 |
5 other studies available for fenfluramine and Obesity, Morbid
| Article | Year |
|---|---|
Psychotic mania associated with fenfluramine and phentermine use.
Topics: 1-Naphthylamine; Bipolar Disorder; Depressive Disorder; Female; Fenfluramine; Humans; Middle Aged; O | 1997 |
Debate over dexfenfluramine.
Topics: Appetite Depressants; Body Mass Index; Fenfluramine; Humans; Hypertension, Pulmonary; Logistic Model | 1997 |
[The psychophysiological aspects of treating obesity with Izolipan].
Topics: Acoustic Stimulation; Adult; Appetite Depressants; Brain; Contingent Negative Variation; Drug Evalua | 1996 |
With new diet drug, challenge is weighing patient demand and potential benefit.
Topics: Appetite Depressants; Fenfluramine; Humans; Obesity, Morbid; Risk Factors | 1996 |
Prolonged use of a very low calorie diet (Cambridge diet) in massively obese patients attending an obesity clinic: safety, efficacy and additional benefit from dexfenfluramine.
Topics: Adult; Appetite Depressants; Diet, Reducing; Energy Intake; Fenfluramine; Humans; Obesity, Morbid; W | 1989 |