fenfluramine has been researched along with Nervous System Disorders in 7 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Results of these dose-response experiments indicated that there was no significant effect upon fenfluramine discrimination after multiple saline injections or after 10 days without training." | 1.28 | Functional consequences of fenfluramine neurotoxicity. ( Schechter, MD, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Voelker, R | 1 |
| Cozzi, NV | 1 |
| Frescas, S | 1 |
| Marona-Lewicka, D | 1 |
| Huang, X | 1 |
| Nichols, DE | 1 |
| Chase, TN | 1 |
| Shoulson, I | 1 |
| Walsh, SL | 1 |
| Wagner, GC | 1 |
| Schmidt, CJ | 1 |
| Black, CK | 1 |
| Taylor, VL | 1 |
| Schechter, MD | 1 |
1 trial available for fenfluramine and Nervous System Disorders
| Article | Year |
|---|---|
Behavioural and biochemical effects of fenfluramine in patients with neurologic disease.
Topics: Adult; Behavior; Body Weight; Female; Fenfluramine; Humans; Male; Middle Aged; Nervous System Diseas | 1975 |
6 other studies available for fenfluramine and Nervous System Disorders
| Article | Year |
|---|---|
Benfluorex: negative data in France, but still on the market. Neuropsychiatric disorders, pulmonary hypertension and heart valve damage.
Topics: Appetite Depressants; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; N | 2009 |
Obesity drug renews toxicity debate.
Topics: Animals; Drug Approval; Fenfluramine; Humans; Nervous System Diseases; Obesity; United States; Unite | 1994 |
Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential.
Topics: Animals; Appetite Depressants; Body Weight; Brain Chemistry; Discrimination, Psychological; Fenflura | 1998 |
Motor impairments after methamphetamine-induced neurotoxicity in the rat.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Dopamine; Fenfluramine; Levodopa; Male; Methamp | 1992 |
L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dopamine; | 1991 |
Functional consequences of fenfluramine neurotoxicity.
Topics: Animals; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Fenfluram | 1990 |