fenfluramine has been researched along with Nerve Degeneration in 12 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dexfenfluramine treatment decreased the density of 5-HT uptake sites in the cortex, labelled with [3H]-citalopram, but this partially recovered towards control values at 60 days." | 1.29 | Repeated administration of escalating high doses of dexfenfluramine does not produce morphological evidence for neurotoxicity in the cortex of rats. ( Collins, P; Hindmarsh, JG; Hunt, S; Jenner, P; Rose, S, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yuan, J | 1 |
| Cord, BJ | 1 |
| McCann, UD | 1 |
| Callahan, BT | 1 |
| Ricaurte, GA | 1 |
| Mennini, T | 1 |
| Pataccini, R | 1 |
| Crunelli, V | 1 |
| Caccia, S | 1 |
| Ballabio, M | 1 |
| Samanin, R | 1 |
| Garattini, S | 1 |
| Parenti, M | 1 |
| Tirone, F | 1 |
| Olgiati, VR | 1 |
| Groppetti, A | 1 |
| Kirby, LG | 1 |
| Kreiss, DS | 1 |
| Singh, A | 1 |
| Lucki, I | 1 |
| Baumann, MH | 1 |
| Schuster, CR | 1 |
| Rothman, RB | 1 |
| Rose, S | 1 |
| Hunt, S | 1 |
| Collins, P | 1 |
| Hindmarsh, JG | 1 |
| Jenner, P | 1 |
| Murray, TK | 2 |
| Williams, JL | 1 |
| Misra, A | 1 |
| Colado, MI | 2 |
| Green, AR | 2 |
| O'Shea, E | 1 |
| Granados, R | 1 |
| Huang, M | 1 |
| Liu, W | 1 |
| Li, Q | 1 |
| Wu, CF | 1 |
| Schettini, G | 1 |
| Quattrone, A | 1 |
| Gianfranco, DR | 1 |
| Preziosi, P | 1 |
| Schmidt, CJ | 1 |
| Black, CK | 1 |
| Taylor, VL | 1 |
| Molliver, DC | 1 |
| Molliver, ME | 1 |
12 other studies available for fenfluramine and Nerve Degeneration
| Article | Year |
|---|---|
Effect of glucoprivation on serotonin neurotoxicity induced by substituted amphetamines.
Topics: Amphetamines; Animals; Antimetabolites; Biogenic Monoamines; Body Temperature; Carrier Proteins; Deo | 2002 |
Localization of fenfluramine and reserpine in brain regions of rats with extensive degeneration of 5-hydroxytryptaminergic neurons.
Topics: Animals; Brain; Corpus Striatum; Female; Fenfluramine; Nerve Degeneration; Raphe Nuclei; Rats; Recep | 1980 |
Presence of opiate receptors on striatal serotoninergic nerve terminals.
Topics: Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Fenfluramine; Hydroxyindoleacetic Acid; | 1983 |
Effect of destruction of serotonin neurons on basal and fenfluramine-induced serotonin release in striatum.
Topics: 5,7-Dihydroxytryptamine; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Fenfluramine; M | 1995 |
Effects of phentermine and cocaine on fenfluramine-induced depletion of serotonin in mouse brain.
Topics: Animals; Appetite Depressants; Brain; Cocaine; Dopamine; Dose-Response Relationship, Drug; Drug Inte | 1996 |
Repeated administration of escalating high doses of dexfenfluramine does not produce morphological evidence for neurotoxicity in the cortex of rats.
Topics: Animals; Appetite Depressants; Binding Sites; Biomarkers; Cerebral Cortex; Citalopram; Fenfluramine; | 1996 |
The spin trap reagent PBN attenuates degeneration of 5-HT neurones in rat brain induced by p-chloroamphetamine but not fenfluramine.
Topics: Animals; Body Temperature; Brain; Brain Chemistry; Cyclic N-Oxides; Fenfluramine; Hydroxyindoleaceti | 1996 |
In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine.
Topics: Animals; Biogenic Monoamines; Body Temperature; Brain Chemistry; Fenfluramine; Free Radical Scavenge | 1997 |
Endogenous released ascorbic acid suppresses ethanol-induced hydroxyl radical production in rat striatum.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Ascorbic Acid; Drug Interactions; Ethanol; Extra | 2002 |
Effect of selective degeneration of brain serotonin-containing neurons on plasma corticosterone levels: studies with d-fenfluramine.
Topics: 5,7-Dihydroxytryptamine; Animals; Brain; Brain Chemistry; Catecholamines; Corticosterone; Fenflurami | 1979 |
L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dopamine; | 1991 |
Anatomic evidence for a neurotoxic effect of (+/-)-fenfluramine upon serotonergic projections in the rat.
Topics: Animals; Fenfluramine; Frontal Lobe; Nerve Degeneration; Neurotoxins; Rats; Serotonin | 1990 |