Page last updated: 2024-10-27

fenfluramine and Nerve Degeneration

fenfluramine has been researched along with Nerve Degeneration in 12 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Research Excerpts

ExcerptRelevanceReference
"Dexfenfluramine treatment decreased the density of 5-HT uptake sites in the cortex, labelled with [3H]-citalopram, but this partially recovered towards control values at 60 days."1.29Repeated administration of escalating high doses of dexfenfluramine does not produce morphological evidence for neurotoxicity in the cortex of rats. ( Collins, P; Hindmarsh, JG; Hunt, S; Jenner, P; Rose, S, 1996)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's7 (58.33)18.2507
2000's2 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yuan, J1
Cord, BJ1
McCann, UD1
Callahan, BT1
Ricaurte, GA1
Mennini, T1
Pataccini, R1
Crunelli, V1
Caccia, S1
Ballabio, M1
Samanin, R1
Garattini, S1
Parenti, M1
Tirone, F1
Olgiati, VR1
Groppetti, A1
Kirby, LG1
Kreiss, DS1
Singh, A1
Lucki, I1
Baumann, MH1
Schuster, CR1
Rothman, RB1
Rose, S1
Hunt, S1
Collins, P1
Hindmarsh, JG1
Jenner, P1
Murray, TK2
Williams, JL1
Misra, A1
Colado, MI2
Green, AR2
O'Shea, E1
Granados, R1
Huang, M1
Liu, W1
Li, Q1
Wu, CF1
Schettini, G1
Quattrone, A1
Gianfranco, DR1
Preziosi, P1
Schmidt, CJ1
Black, CK1
Taylor, VL1
Molliver, DC1
Molliver, ME1

Other Studies

12 other studies available for fenfluramine and Nerve Degeneration

ArticleYear
Effect of glucoprivation on serotonin neurotoxicity induced by substituted amphetamines.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Amphetamines; Animals; Antimetabolites; Biogenic Monoamines; Body Temperature; Carrier Proteins; Deo

2002
Localization of fenfluramine and reserpine in brain regions of rats with extensive degeneration of 5-hydroxytryptaminergic neurons.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:7

    Topics: Animals; Brain; Corpus Striatum; Female; Fenfluramine; Nerve Degeneration; Raphe Nuclei; Rats; Recep

1980
Presence of opiate receptors on striatal serotoninergic nerve terminals.
    Brain research, 1983, Dec-05, Volume: 280, Issue:2

    Topics: Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Fenfluramine; Hydroxyindoleacetic Acid;

1983
Effect of destruction of serotonin neurons on basal and fenfluramine-induced serotonin release in striatum.
    Synapse (New York, N.Y.), 1995, Volume: 20, Issue:2

    Topics: 5,7-Dihydroxytryptamine; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Fenfluramine; M

1995
Effects of phentermine and cocaine on fenfluramine-induced depletion of serotonin in mouse brain.
    Drug and alcohol dependence, 1996, Volume: 41, Issue:1

    Topics: Animals; Appetite Depressants; Brain; Cocaine; Dopamine; Dose-Response Relationship, Drug; Drug Inte

1996
Repeated administration of escalating high doses of dexfenfluramine does not produce morphological evidence for neurotoxicity in the cortex of rats.
    Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, 1996, Volume: 5, Issue:2

    Topics: Animals; Appetite Depressants; Binding Sites; Biomarkers; Cerebral Cortex; Citalopram; Fenfluramine;

1996
The spin trap reagent PBN attenuates degeneration of 5-HT neurones in rat brain induced by p-chloroamphetamine but not fenfluramine.
    Neuropharmacology, 1996, Volume: 35, Issue:11

    Topics: Animals; Body Temperature; Brain; Brain Chemistry; Cyclic N-Oxides; Fenfluramine; Hydroxyindoleaceti

1996
In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine.
    British journal of pharmacology, 1997, Volume: 121, Issue:5

    Topics: Animals; Biogenic Monoamines; Body Temperature; Brain Chemistry; Fenfluramine; Free Radical Scavenge

1997
Endogenous released ascorbic acid suppresses ethanol-induced hydroxyl radical production in rat striatum.
    Brain research, 2002, Jul-19, Volume: 944, Issue:1-2

    Topics: Alcohol-Induced Disorders, Nervous System; Animals; Ascorbic Acid; Drug Interactions; Ethanol; Extra

2002
Effect of selective degeneration of brain serotonin-containing neurons on plasma corticosterone levels: studies with d-fenfluramine.
    Pharmacological research communications, 1979, Volume: 11, Issue:6

    Topics: 5,7-Dihydroxytryptamine; Animals; Brain; Brain Chemistry; Catecholamines; Corticosterone; Fenflurami

1979
L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats.
    European journal of pharmacology, 1991, Oct-02, Volume: 203, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dopamine;

1991
Anatomic evidence for a neurotoxic effect of (+/-)-fenfluramine upon serotonergic projections in the rat.
    Brain research, 1990, Mar-12, Volume: 511, Issue:1

    Topics: Animals; Fenfluramine; Frontal Lobe; Nerve Degeneration; Neurotoxins; Rats; Serotonin

1990