fenfluramine has been researched along with Muscle Contraction in 14 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We determined the effects of D-fenfluramine treatment on the changes in vascular reactivity induced by aging." | 3.68 | Effect of aging and drug-induced weight reduction on rat vascular reactivity. ( Boulanger, M; Duhault, J; Feletou, M; Moreau, N, 1993) |
| "Quipazine was also effective when administered into a lateral cerebral ventricle." | 1.27 | Effects of serotonin agonists on lordosis, myoclonus, and cytoplasmic progestin receptors in guinea pigs. ( Feder, HH; O'Connor, LH, 1983) |
| "Zotepine was also the most potent inhibitor of 3H-serotonin binding to rat cortical synaptosomes in vitro." | 1.26 | The central anti-serotonin activity of zotepine, a new neuroleptic, in rats. ( Hirai, O; Katsuki, S; Mori, J; Motoyama, Y; Ono, T; Satoh, H; Shimomura, K; Terai, T; Tomoi, M, 1982) |
| "Pimozide has no such effect." | 1.26 | The effect of haloperidol, spiperone and pimozide on the flexor reflex of the hind limb of the spinal rat. ( Maj, J; Palider, W; Rawłów, A, 1978) |
| "Pre-treatment with debrisoquine (0." | 1.26 | The sympathomimetic activity of fenfluramine hydrochloride on rat vas deferens. ( Mottram, DR; Wadhwani, D, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (71.43) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brezina, V | 1 |
| Horn, CC | 1 |
| Weiss, KR | 1 |
| Shimomura, K | 1 |
| Satoh, H | 1 |
| Hirai, O | 1 |
| Mori, J | 1 |
| Tomoi, M | 1 |
| Terai, T | 1 |
| Katsuki, S | 1 |
| Motoyama, Y | 1 |
| Ono, T | 1 |
| O'Connor, LH | 1 |
| Feder, HH | 1 |
| Feletou, M | 1 |
| Moreau, N | 1 |
| Boulanger, M | 1 |
| Duhault, J | 1 |
| Béjar, E | 1 |
| Clineschmidt, BV | 1 |
| McGuffin, JC | 1 |
| Mottram, DR | 2 |
| Patel, RJ | 1 |
| Maj, J | 2 |
| Palider, W | 2 |
| Rawłów, A | 1 |
| Wadhwani, D | 1 |
| Baran, L | 1 |
| Rawlow, A | 1 |
| King, RG | 1 |
| Coupar, IM | 2 |
| Hedges, A | 1 |
| Metcalfe, HL | 1 |
| Turner, P | 1 |
| Kirby, MJ | 2 |
14 other studies available for fenfluramine and Muscle Contraction
| Article | Year |
|---|---|
Modeling neuromuscular modulation in Aplysia. III. Interaction of central motor commands and peripheral modulatory state for optimal behavior.
Topics: Action Potentials; Animals; Aplysia; Behavior, Animal; Calcium; Dose-Response Relationship, Drug; Do | 2005 |
The central anti-serotonin activity of zotepine, a new neuroleptic, in rats.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Body Temperature; Dibenzothiepins; Fenfluramine | 1982 |
Effects of serotonin agonists on lordosis, myoclonus, and cytoplasmic progestin receptors in guinea pigs.
Topics: Animals; Cytoplasm; Dose-Response Relationship, Drug; Estradiol; Female; Fenfluramine; Guinea Pigs; | 1983 |
Effect of aging and drug-induced weight reduction on rat vascular reactivity.
Topics: Administration, Oral; Aging; Animals; Aorta; Blood Glucose; Body Weight; Endothelium, Vascular; Fenf | 1993 |
Parthenolide inhibits the contractile responses of rat stomach fundus to fenfluramine and dextroamphetamine but not serotonin.
Topics: Animals; Dextroamphetamine; Fenfluramine; Gastric Fundus; In Vitro Techniques; Muscle Contraction; P | 1996 |
Pharmacological differentiation of the central 5-hydroxytryptamine-like actions of MK-212 (6-chloro-2[1-piperazinyl]-pyrazine),p-methoxyamphetamine and fenfluramine in an in vivo model system.
Topics: Amphetamines; Animals; Dextroamphetamine; Drug Interactions; Fenclonine; Fenfluramine; Fluoxetine; I | 1978 |
Peripheral effects of fenfluramine mediated via the release of 5-hydroxytryptamine.
Topics: Animals; Cyproheptadine; Digestive System; Drug Interactions; Fenfluramine; Guinea Pigs; Histamine; | 1979 |
The effect of haloperidol, spiperone and pimozide on the flexor reflex of the hind limb of the spinal rat.
Topics: Animals; Butyrophenones; Clonidine; Denervation; Fenfluramine; Haloperidol; Hindlimb; Lysergic Acid | 1978 |
The sympathomimetic activity of fenfluramine hydrochloride on rat vas deferens.
Topics: Animals; Debrisoquin; Desipramine; Drug Interactions; Fenfluramine; In Vitro Techniques; Male; Muscl | 1977 |
The effects of serotonergic and antiserotonergic drugs on the flexor reflex of spinal rat: a proposed model to evaluate the action on the central serotonin receptor.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anthracenes; Clonidine; Cyproheptadine; Decerebrate State | 1976 |
A novel in vivo test for drugs affecting central serotonergic and adrenergic systems.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Albuterol; Animals; Cl | 1990 |
Action of fenfluramine on isolated human smooth muscle.
Topics: Acetylcholine; Appetite Depressants; Dextroamphetamine; Drug Antagonism; Fenfluramine; Fluorine; Hum | 1969 |
The effect of clonidine on human isolated smooth muscle.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Antihypertensive Agents; Clonidine; Colon; Drug Antagon | 1972 |
Influence of calcium on responses of human isolated uterine tissue to fenfluramine.
Topics: Appetite Depressants; Calcium; Female; Fenfluramine; Fluorine; Humans; In Vitro Techniques; Isoprote | 1971 |