Page last updated: 2024-10-27

fenfluramine and Morphine Abuse

fenfluramine has been researched along with Morphine Abuse in 4 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19903 (75.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Samanin, R1
Cervo, L1
Rochat, C1
Contreras, E1
Tamayo, L1
Quijada, L1
Muñoz, M1
Akaoka, H1
Aston-Jones, G1
Opitz, K1
Reimann, I1

Other Studies

4 other studies available for fenfluramine and Morphine Abuse

ArticleYear
Changes of physical morphine dependence in rats chronically treated with drugs acting on brain 5-hydroxytryptamine.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:2

    Topics: Animals; Brain Chemistry; Fenfluramine; Humans; Male; Metergoline; Morphine Dependence; Rats; Seroto

1980
Decrease of tolerance and physical dependence on morphine by drugs affecting brain serotonin.
    Cellular and molecular biology, including cyto-enzymology, 1980, Volume: 26, Issue:4

    Topics: 5-Hydroxytryptophan; Animals; Brain Chemistry; Fenfluramine; Humans; Mice; Morphine Dependence; Nalo

1980
Indirect serotonergic agonists attenuate neuronal opiate withdrawal.
    Neuroscience, 1993, Volume: 54, Issue:3

    Topics: 1-Naphthylamine; Animals; Fenclonine; Fenfluramine; Kynurenine; Locus Coeruleus; Morphine Dependence

1993
Suppression of the drug-induced morphine withdrawal syndrome by cyproheptadine.
    Psychopharmacologia, 1973, Jan-01, Volume: 28, Issue:2

    Topics: Animals; Body Weight; Cyproheptadine; Drug Tolerance; Fenfluramine; Humans; Hypothalamus; Levallorph

1973