fenfluramine has been researched along with Mood Disorders in 5 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased research focusing on the eating disorders has put the clinician on firmer ground when choosing appropriate psychopharmacologic treatments." | 2.37 | Pharmacologic treatment of eating disorders. ( Gwirtsman, H; Jimerson, DC; Kaye, W; Weintraub, M, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gwirtsman, H | 1 |
| Kaye, W | 1 |
| Weintraub, M | 1 |
| Jimerson, DC | 1 |
| Coccaro, EF | 1 |
| Kavoussi, RJ | 1 |
| Hauger, RL | 1 |
| López-Ibor, JJ | 1 |
| Saiz-Ruiz, J | 1 |
| Iglesias, LM | 1 |
| O'Rourke, DA | 1 |
| Wurtman, JJ | 1 |
| Brzezinski, A | 1 |
| Nader, TA | 1 |
| Chew, B | 1 |
| Wurtman, J | 1 |
2 reviews available for fenfluramine and Mood Disorders
| Article | Year |
|---|---|
Pharmacologic treatment of eating disorders.
Topics: Anorexia Nervosa; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricyclic; Central | 1984 |
The fenfluramine challenge test in the affective spectrum: a possible marker of endogeneity and severity.
Topics: Adult; Female; Fenfluramine; Growth Hormone; Humans; Hydrocortisone; Male; Middle Aged; Mood Disorde | 1988 |
2 trials available for fenfluramine and Mood Disorders
| Article | Year |
|---|---|
Serotonin function and antiaggressive response to fluoxetine: a pilot study.
Topics: Adolescent; Adolescent Behavior; Adult; Aggression; Double-Blind Method; Fenfluramine; Fluoxetine; H | 1997 |
Serotonin implicated in etiology of seasonal affective disorder.
Topics: Clinical Trials as Topic; Double-Blind Method; Fenfluramine; Humans; Mood Disorders; Random Allocati | 1987 |
1 other study available for fenfluramine and Mood Disorders
| Article | Year |
|---|---|
Recent evidence from human studies linking central serotoninergic function with carbohydrate intake.
Topics: Appetite Regulation; Dietary Carbohydrates; Fenfluramine; Food Preferences; Humans; Mood Disorders; | 1987 |