fenfluramine has been researched along with Migraine Disorders in 5 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is concluded that retinal migraines occurring during oral contraceptive treatment must be considered as a warning sign, that may precede the onset of serious and irreversible disorders." | 1.25 | [Retinal artery complications caused by oral contraceptives]. ( Jamotton, L; Michiels, J, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhattacharyya, S | 1 |
| Schapira, AH | 1 |
| Mikhailidis, DP | 1 |
| Davar, J | 1 |
| Mira, E | 1 |
| Piacentino, G | 1 |
| Lanzi, G | 2 |
| Balottin, U | 2 |
| Fazzi, E | 1 |
| Arisi, D | 1 |
| Frigo, GM | 1 |
| Salmon, S | 1 |
| Curradi, C | 1 |
| Del Bene, E | 1 |
| Sicuteri, F | 1 |
| Jamotton, L | 1 |
| Michiels, J | 1 |
1 review available for fenfluramine and Migraine Disorders
| Article | Year |
|---|---|
Drug-induced fibrotic valvular heart disease.
Topics: Antiparkinson Agents; Appetite Depressants; Cabergoline; Dexfenfluramine; Dopamine Agonists; Drug Mo | 2009 |
4 other studies available for fenfluramine and Migraine Disorders
| Article | Year |
|---|---|
Benign paroxysmal vertigo in childhood: a migraine equivalent.
Topics: Child; Child, Preschool; Female; Fenfluramine; Histamine; Humans; Male; Migraine Disorders; Nitrogly | 1984 |
Iris adrenergic sensitivity and migraine in pediatric patients.
Topics: Adolescent; Child; Child, Preschool; Fenfluramine; Humans; Iris; Migraine Disorders; Phenylephrine; | 1983 |
The possible role of tryptophan in migraine.
Topics: Adult; Blood Platelets; Female; Fenfluramine; Humans; Male; Migraine Disorders; Regression Analysis; | 1996 |
[Retinal artery complications caused by oral contraceptives].
Topics: Adult; Ethinyl Estradiol; Eye; Female; Fenfluramine; Humans; Lynestrenol; Migraine Disorders; Norges | 1972 |