fenfluramine has been researched along with Metabolic Syndrome in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Metabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Body weight, insulin, and leptin were decreased (p < 0." | 3.76 | MR molecular imaging of aortic angiogenesis. ( Cai, K; Caruthers, SD; Huang, W; Lanza, GM; Wickline, SA; Williams, TA; Winter, PM; Zhang, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, K | 1 |
| Caruthers, SD | 1 |
| Huang, W | 1 |
| Williams, TA | 1 |
| Zhang, H | 1 |
| Wickline, SA | 1 |
| Lanza, GM | 1 |
| Winter, PM | 1 |
| Muldoon, MF | 1 |
| Mackey, RH | 1 |
| Williams, KV | 1 |
| Korytkowski, MT | 1 |
| Flory, JD | 1 |
| Manuck, SB | 1 |
2 other studies available for fenfluramine and Metabolic Syndrome
| Article | Year |
|---|---|
MR molecular imaging of aortic angiogenesis.
Topics: Animals; Aorta; Appetite Depressants; Atherosclerosis; Body Weight; Cholesterol; Disease Models, Ani | 2010 |
Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity.
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Brain; Female; Fenfluramine; Humans; Insulin; | 2004 |