fenfluramine has been researched along with Liver Failure, Acute in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two patients developed fulminant hepatic failure: 1 patient required liver transplantation, and the other patient died." | 1.32 | Hepatic injury in 12 patients taking the herbal weight loss AIDS Chaso or Onshido. ( Adachi, M; Horie, Y; Ishii, H; Kato, S; Kobayashi, H; Saito, H; Yoshioka, M, 2003) |
| "A 42-year-old female developed fulminant hepatic failure after having ingested an undetermined quantity of a herbal product over a period of approximately four months prior to the onset of her illness." | 1.32 | A fatal case of hepatic failure possibly induced by nitrosofenfluramine: a case report. ( Chan, CL; Chu, SS; Lau, G; Leong, HT; Lo, DS; Yao, YJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adachi, M | 1 |
| Saito, H | 1 |
| Kobayashi, H | 1 |
| Horie, Y | 1 |
| Kato, S | 1 |
| Yoshioka, M | 1 |
| Ishii, H | 1 |
| Kawata, K | 1 |
| Takehira, Y | 1 |
| Kobayashi, Y | 1 |
| Kitagawa, M | 1 |
| Yamada, M | 1 |
| Hanajima, K | 1 |
| Murohisa, G | 1 |
| Kawamura, M | 1 |
| Iwaoka, Y | 1 |
| Wada, T | 1 |
| Morita, S | 1 |
| Iwaizumi, M | 1 |
| Makino, S | 1 |
| Lau, G | 1 |
| Lo, DS | 1 |
| Yao, YJ | 1 |
| Leong, HT | 1 |
| Chan, CL | 1 |
| Chu, SS | 1 |
4 other studies available for fenfluramine and Liver Failure, Acute
| Article | Year |
|---|---|
Hepatic injury in 12 patients taking the herbal weight loss AIDS Chaso or Onshido.
Topics: Adult; Chemical and Drug Induced Liver Injury; Dietary Supplements; Drugs, Chinese Herbal; Female; F | 2003 |
Summaries for patients. Liver injury in 12 patients taking the herbal weight loss aids Chaso or Onshido.
Topics: Adult; Chemical and Drug Induced Liver Injury; Dietary Supplements; Drugs, Chinese Herbal; Female; F | 2003 |
Three cases of liver injury caused by Sennomotokounou, a Chinese dietary supplement for weight loss.
Topics: Adult; Anti-Obesity Agents; Drugs, Chinese Herbal; Female; Fenfluramine; Humans; Hyperthyroidism; Li | 2003 |
A fatal case of hepatic failure possibly induced by nitrosofenfluramine: a case report.
Topics: Adult; Anti-Obesity Agents; Autopsy; Drug Contamination; Drugs, Chinese Herbal; Fatal Outcome; Femal | 2004 |