Page last updated: 2024-10-27

fenfluramine and Liver Dysfunction

fenfluramine has been researched along with Liver Dysfunction in 3 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Smith, DA1
Schmid, EF1
Lin, X1
Levitsky, DA1
King, JM1
Campbell, TC1
Goldberg, A1
Krasner, N1
Dow, J1
MacDonald, CM1
Moore, MR1

Reviews

1 review available for fenfluramine and Liver Dysfunction

ArticleYear
Drug withdrawals and the lessons within.
    Current opinion in drug discovery & development, 2006, Volume: 9, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbolines; Colitis, Ischemic; Drug Design; Drug-R

2006

Other Studies

2 other studies available for fenfluramine and Liver Dysfunction

ArticleYear
The promotion effect of anorectic drugs on aflatoxin B(1)-induced hepatic preneoplastic foci.
    Carcinogenesis, 1999, Volume: 20, Issue:9

    Topics: Adipose Tissue, Brown; Aflatoxin B1; Amphetamine; Animals; Appetite Depressants; Biomarkers; Body Te

1999
Clinical and experimental studies on alcoholism.
    Health bulletin, 1973, Volume: 31, Issue:6

    Topics: Alcohol Deterrents; Alcoholism; Animals; Disulfiram; Ethanol; Fenfluramine; Humans; Liver Diseases;

1973