fenfluramine has been researched along with Lipodystrophy in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Lipodystrophy: A collection of heterogenous conditions resulting from defective LIPID METABOLISM and characterized by ADIPOSE TISSUE atrophy. Often there is redistribution of body fat resulting in peripheral fat wasting and central adiposity. They include generalized, localized, congenital, and acquired lipodystrophy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine has a lowering effect on brain serotonin, and peripheral effects on glucose and triglyceride metabolism." | 5.26 | Congenital generalized lipodystrophy and experimental lipoatrophic diabetes in rabbits treated successfully with fenfluramine. ( Foss, I; Trygstad, O, 1977) |
| "Fat cell size and lipid composition of subcutaneous tissue from 3 patients with congenital generalized lipodystrophy have been measured before and after treatment with either pimozide, fenfluramine or hypophysectomy." | 3.66 | Fat cell size and lipid content of subcutaneous tissue in congenital generalized lipodystrophy. ( Bjerve, KS; Oseid, S; Rognum, TO; Seip, M; Trygstad, O, 1978) |
| "Fenfluramine has a lowering effect on brain serotonin, and peripheral effects on glucose and triglyceride metabolism." | 1.26 | Congenital generalized lipodystrophy and experimental lipoatrophic diabetes in rabbits treated successfully with fenfluramine. ( Foss, I; Trygstad, O, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harano, Y | 1 |
| Trygstad, O | 3 |
| Foss, I | 1 |
| Rognum, TO | 1 |
| Bjerve, KS | 1 |
| Seip, M | 2 |
| Oseid, S | 2 |
1 review available for fenfluramine and Lipodystrophy
| Article | Year |
|---|---|
[Lipodystrophy].
Topics: Diagnosis, Differential; Diet Therapy; Fenfluramine; Humans; Insulin-Like Growth Factor I; Lipodystr | 1998 |
3 other studies available for fenfluramine and Lipodystrophy
| Article | Year |
|---|---|
Congenital generalized lipodystrophy and experimental lipoatrophic diabetes in rabbits treated successfully with fenfluramine.
Topics: Adult; Animals; Blood Glucose; Brain; Diabetes Complications; Diabetes Mellitus; Fenfluramine; Gluco | 1977 |
Fat cell size and lipid content of subcutaneous tissue in congenital generalized lipodystrophy.
Topics: Adipose Tissue; Adult; Child; Female; Fenfluramine; Humans; Hypophysectomy; Lipid Metabolism; Lipody | 1978 |
Lipodystrophic diabetes treated with fenfluramine.
Topics: Adolescent; Blood Glucose; Diabetes Mellitus; Female; Fenfluramine; Humans; Lipids; Lipodystrophy | 1977 |