fenfluramine has been researched along with Lassitude in 9 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine is an effective antiepileptic drug for pediatric patients with Dravet syndrome, demonstrating clinically meaningful reduction in convulsive frequency, and generally could be well tolerated." | 2.72 | Efficacy and safety of fenfluramine in patients with Dravet syndrome: A meta-analysis. ( Li, W; Wang, C; Zhang, L, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, L | 1 |
| Li, W | 1 |
| Wang, C | 1 |
| Keilp, JG | 1 |
| Oquendo, MA | 1 |
| Stanley, BH | 1 |
| Burke, AK | 1 |
| Cooper, TB | 1 |
| Malone, KM | 1 |
| Mann, JJ | 1 |
| Brownell, KD | 1 |
| Stunkard, AJ | 1 |
| Kogon, MM | 1 |
| Kräuchi, K | 1 |
| Van der Velde, P | 1 |
| Van der Werf, H | 1 |
| Keller, U | 1 |
| Abdel-Kader, MM | 1 |
| Mashaly, M | 1 |
| Abdel-Aziz, MT | 1 |
| Greenwood, MH | 1 |
| Haug, E | 1 |
| Myklebust, R | 1 |
| Jervell, J | 1 |
| Gaind, R | 1 |
2 reviews available for fenfluramine and Lassitude
| Article | Year |
|---|---|
Efficacy and safety of fenfluramine in patients with Dravet syndrome: A meta-analysis.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Fatigue; Fenfluramine; Fever; Human | 2021 |
[Side effects associated with prolonged use of fenfluramine].
Topics: Depersonalization; Diarrhea; Fatigue; Fenfluramine; Humans; Libido; Sleep; Substance-Related Disorde | 1973 |
5 trials available for fenfluramine and Lassitude
| Article | Year |
|---|---|
Future suicide attempt and responses to serotonergic challenge.
Topics: Adult; Affect; Age Factors; Area Under Curve; Depressive Disorder; Fatigue; Female; Fenfluramine; Fo | 2010 |
The double-blind in danger: untoward consequences of informed consent.
Topics: Adult; Aged; Body Weight; Clinical Trials as Topic; Dizziness; Double-Blind Method; Fatigue; Female; | 1982 |
Psychological and metabolic effects of dietary carbohydrates and dexfenfluramine during a low-energy diet in obese women.
Topics: Adult; Affect; Blood Pressure; Body Weight; Diet, Reducing; Dietary Carbohydrates; Energy Intake; En | 1994 |
[The therapeutic effect of Fenfluramine on body weight in overweight patients. A controlled clinical study].
Topics: Adolescent; Adult; Blood Pressure; Clinical Trials as Topic; Constipation; Depression, Chemical; Dia | 1973 |
Fenfluramine (Ponderax) in the treatment of obese psychiatric out-patients.
Topics: Anxiety Disorders; Appetite Depressants; Body Weight; Clinical Trials as Topic; Depression; Diarrhea | 1969 |
2 other studies available for fenfluramine and Lassitude
| Article | Year |
|---|---|
Clinical and biochemical studies on obese subjects using fenfluramine.
Topics: Anorexia Nervosa; Blood Pressure; Diarrhea; Fatigue; Female; Fenfluramine; Glucose Tolerance Test; H | 1974 |
[Drug therapy of obesity].
Topics: Diarrhea; Fatigue; Fenfluramine; Humans; Obesity | 1973 |