Page last updated: 2024-10-27

fenfluramine and Labhart-Willi Syndrome

fenfluramine has been researched along with Labhart-Willi Syndrome in 2 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research Excerpts

ExcerptRelevanceReference
"A double blind trial was conducted to determine the effect of fenfluramine on the weight and behaviour of patients with the Prader-Willi syndrome."9.06Fenfluramine in Prader-Willi syndrome: a double blind, placebo controlled trial. ( Pendergast, A; Selikowitz, M; Sunman, J; Wright, S, 1990)
"A double blind trial was conducted to determine the effect of fenfluramine on the weight and behaviour of patients with the Prader-Willi syndrome."5.06Fenfluramine in Prader-Willi syndrome: a double blind, placebo controlled trial. ( Pendergast, A; Selikowitz, M; Sunman, J; Wright, S, 1990)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tu, JB1
Hartridge, C1
Izawa, J1
Selikowitz, M1
Sunman, J1
Pendergast, A1
Wright, S1

Trials

1 trial available for fenfluramine and Labhart-Willi Syndrome

ArticleYear
Fenfluramine in Prader-Willi syndrome: a double blind, placebo controlled trial.
    Archives of disease in childhood, 1990, Volume: 65, Issue:1

    Topics: Adolescent; Adult; Body Weight; Child; Child Behavior; Child, Preschool; Double-Blind Method; Female

1990

Other Studies

1 other study available for fenfluramine and Labhart-Willi Syndrome

ArticleYear
Psychopharmacogenetic aspects of Prader-Willi syndrome.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:6

    Topics: Adolescent; Aggression; Appetite Depressants; Behavior Therapy; Carbamazepine; Combined Modality The

1992