Page last updated: 2024-10-27

fenfluramine and Kidney Diseases

fenfluramine has been researched along with Kidney Diseases in 3 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Malak, J1
Van Ypersele de Strihou, C1
Ono, T1
Eri, M1
Honda, G1
Kuwahara, T1

Other Studies

3 other studies available for fenfluramine and Kidney Diseases

ArticleYear
Chinese herb nephropathy is not a (dex)fenfluramine nephropathy but a serotonin nephropathy.
    Journal of alternative and complementary medicine (New York, N.Y.), 1998,Summer, Volume: 4, Issue:2

    Topics: Belgium; Drugs, Chinese Herbal; Fenfluramine; Humans; Incidence; Kidney; Kidney Diseases; Risk Facto

1998
Valvular heart disease and Chinese-herb nephropathy.
    Lancet (London, England), 1998, Mar-28, Volume: 351, Issue:9107

    Topics: Aortic Valve Insufficiency; Appetite Depressants; Drug Therapy, Combination; Drugs, Chinese Herbal;

1998
Valvular heart disease and Chinese-herb nephropathy.
    Lancet (London, England), 1998, Mar-28, Volume: 351, Issue:9107

    Topics: Aortic Valve Insufficiency; Drug Therapy, Combination; Drugs, Chinese Herbal; Fenfluramine; Humans;

1998