Page last updated: 2024-10-27

fenfluramine and Inadequate Sleep

fenfluramine has been researched along with Inadequate Sleep in 2 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Goodman, WK1
McDougle, CJ1
Barr, LC1
Aronson, SC1
Price, LH1
Kasper, S1
Vieira, A1
Wehr, TA1
Schmidt, R1
Kick, H1
Voll, G1
Murphy, DL1

Reviews

1 review available for fenfluramine and Inadequate Sleep

ArticleYear
Biological approaches to treatment-resistant obsessive compulsive disorder.
    The Journal of clinical psychiatry, 1993, Volume: 54 Suppl

    Topics: Behavior Therapy; Buspirone; Clonazepam; Combined Modality Therapy; Decision Trees; Drug Therapy, Co

1993

Other Studies

1 other study available for fenfluramine and Inadequate Sleep

ArticleYear
Serotonergically induced hormonal responses and the antidepressant effect of total sleep deprivation in patients with major depression.
    Psychopharmacology bulletin, 1988, Volume: 24, Issue:3

    Topics: Depressive Disorder; Female; Fenfluramine; Hormones; Humans; Serotonin; Sleep Deprivation

1988