fenfluramine has been researched along with Hypothyroidism in 6 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypothyroidism is associated with both reduced central 5-HT function and an increased incidence of depression." | 5.29 | Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism. ( Chambers, SM; Cleare, AJ; Dawling, S; McGregor, A; O'Keane, V, 1996) |
| "To evaluate whether the inhibitory control of TSH and the stimulatory control of prolactin (PRL) secretion exerted by endogenous serotonin was altered in obesity, 22 obese men and 10 normal controls were tested with TRH (200 micrograms IV bolus) in the presence (experimental test) and absence (control test) of the serotonergic agonist fenfluramine (60 mg PO 90 min before TRH)." | 5.06 | Serotonergic control of TSH and PRL secretion in obese men. ( Camellini, L; Capretti, L; Coiro, V; Davoli, C; Marchesi, C; Passeri, M; Rossi, G; Roti, E; Speroni, G; Volpi, R, 1990) |
| "Obesity is a morbid condition with hemodynamic consequences affecting the systemic and pulmonary circulations leading to a risk of pulmonary hypertension." | 2.41 | [Pulmonary hypertension and obesity]. ( Humbert, M; Ioos, V; Parent, F; Simonneau, G; Sitbon, O; Sztrymf, B, 2002) |
| "Hypothyroidism is associated with both reduced central 5-HT function and an increased incidence of depression." | 1.29 | Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism. ( Chambers, SM; Cleare, AJ; Dawling, S; McGregor, A; O'Keane, V, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Badauê-Passos, D | 1 |
| Ventura, RR | 1 |
| Silva, LF | 1 |
| Olivares, EL | 1 |
| Reis, LC | 1 |
| Cleare, AJ | 2 |
| McGregor, A | 2 |
| O'Keane, V | 2 |
| Chambers, SM | 1 |
| Dawling, S | 1 |
| Lin, X | 1 |
| Levitsky, DA | 1 |
| King, JM | 1 |
| Campbell, TC | 1 |
| Sztrymf, B | 1 |
| Ioos, V | 1 |
| Sitbon, O | 1 |
| Parent, F | 1 |
| Simonneau, G | 1 |
| Humbert, M | 1 |
| Coiro, V | 1 |
| Passeri, M | 1 |
| Capretti, L | 1 |
| Speroni, G | 1 |
| Davoli, C | 1 |
| Marchesi, C | 1 |
| Rossi, G | 1 |
| Camellini, L | 1 |
| Volpi, R | 1 |
| Roti, E | 1 |
1 review available for fenfluramine and Hypothyroidism
| Article | Year |
|---|---|
[Pulmonary hypertension and obesity].
Topics: Aminorex; Fenfluramine; Hemodynamics; Humans; Hypertension, Pulmonary; Hypothyroidism; Hypoxia; Obes | 2002 |
1 trial available for fenfluramine and Hypothyroidism
| Article | Year |
|---|---|
Serotonergic control of TSH and PRL secretion in obese men.
Topics: Adult; Diet, Reducing; Fenfluramine; Humans; Hypothyroidism; Male; Obesity; Prolactin; Receptors, Se | 1990 |
4 other studies available for fenfluramine and Hypothyroidism
| Article | Year |
|---|---|
Effect of brain serotoninergic stimulation on sodium appetite of euthyroid and hypothyroid rats.
Topics: Animals; Appetite Regulation; Brain; Drinking; Ergolines; Fenfluramine; Fluoxetine; Hypothyroidism; | 2003 |
Neuroendocrine evidence for an association between hypothyroidism, reduced central 5-HT activity and depression.
Topics: Adult; Depression; Female; Fenfluramine; Humans; Hydrocortisone; Hypothyroidism; Male; Middle Aged; | 1995 |
Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism.
Topics: Adult; Depressive Disorder; Female; Fenfluramine; Humans; Hypothyroidism; Male; Middle Aged; Prognos | 1996 |
The promotion effect of anorectic drugs on aflatoxin B(1)-induced hepatic preneoplastic foci.
Topics: Adipose Tissue, Brown; Aflatoxin B1; Amphetamine; Animals; Appetite Depressants; Biomarkers; Body Te | 1999 |