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fenfluramine and Hypothermia, Accidental

fenfluramine has been researched along with Hypothermia, Accidental in 8 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research Excerpts

ExcerptRelevanceReference
"The antiobesity agent, fenfluramine, produces hypothermia in rodents by an, as yet, uncharacterized mechanism."7.72Fenfluramine-induced hypothermia is associated with cutaneous dilation in conscious rats. ( Subramanian, S; Vollmer, RR, 2004)
"The antiobesity agent, fenfluramine, produces hypothermia in rodents by an, as yet, uncharacterized mechanism."3.72Fenfluramine-induced hypothermia is associated with cutaneous dilation in conscious rats. ( Subramanian, S; Vollmer, RR, 2004)
"Flunarizine is considered to be a calcium channel antagonist; therefore this study was aimed at investigating the effect of flunarizine (given in single doses of 5, 10 and 20 mg/kg p."1.28Some central pharmacological effects of the calcium channel antagonist flunarizine. ( Czyrak, A; Maj, J; Mogilnicka, E, 1991)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's1 (12.50)18.2507
2000's5 (62.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, JX1
Koek, W1
France, CP1
Jacobsen, JP1
Siesser, WB1
Sachs, BD1
Peterson, S1
Cools, MJ1
Setola, V1
Folgering, JH1
Flik, G1
Caron, MG1
Gonzalez, LE1
Parada, MA1
Tucci, S1
Teneud, L1
Overstreet, DH1
Hernandez, L1
Itzhak, Y1
Ali, SF1
Anderson, KL1
Subramanian, S1
Vollmer, RR1
Cryan, JF1
Harkin, A1
Naughton, M1
Kelly, JP1
Leonard, BE1
Czyrak, A1
Mogilnicka, E1
Maj, J1
Srimal, RC1
Singh, HK1
Dhawan, BN1

Other Studies

8 other studies available for fenfluramine and Hypothermia, Accidental

ArticleYear
Food restriction and streptozotocin differentially modify sensitivity to the hypothermic effects of direct- and indirect-acting serotonin receptor agonists in rats.
    European journal of pharmacology, 2009, Jun-24, Volume: 613, Issue:1-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Body Weight; Diet; DOM 2,5-Dimeth

2009
Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.
    Molecular psychiatry, 2012, Volume: 17, Issue:7

    Topics: Animals; Behavior, Animal; Biomarkers; Corticosterone; Depression; Disease Models, Animal; Extracell

2012
A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2003, Volume: 36, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Brain; Breeding; Cerebral Cor

2003
Fenfluramine-induced serotonergic neurotoxicity in mice: lack of neuroprotection by inhibition/ablation of nNOS.
    Journal of neurochemistry, 2003, Volume: 87, Issue:1

    Topics: Animals; Biomarkers; Body Temperature; Carrier Proteins; Corpus Striatum; Enzyme Inhibitors; Fenflur

2003
Fenfluramine-induced hypothermia is associated with cutaneous dilation in conscious rats.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 77, Issue:2

    Topics: Animals; Body Temperature; Fenfluramine; Fluoxetine; Hypothermia; Male; Nicotinic Antagonists; Oxyge

2004
Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action.
    European journal of pharmacology, 2000, Mar-03, Volume: 390, Issue:3

    Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Benzofurans; Body Temperature; Cerebral

2000
Some central pharmacological effects of the calcium channel antagonist flunarizine.
    Journal of neural transmission. General section, 1991, Volume: 83, Issue:3

    Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Body Temperature Regulation; Dopamine; Dopamine Antagonis

1991
Experimental evidence for imipramine like activity of fenfluramine.
    Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 188, Issue:2

    Topics: Animals; Avoidance Learning; Blepharoptosis; Blood Pressure; Body Temperature; Cats; Columbidae; Dru

1970