fenfluramine has been researched along with Hypothermia, Accidental in 8 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antiobesity agent, fenfluramine, produces hypothermia in rodents by an, as yet, uncharacterized mechanism." | 7.72 | Fenfluramine-induced hypothermia is associated with cutaneous dilation in conscious rats. ( Subramanian, S; Vollmer, RR, 2004) |
| "The antiobesity agent, fenfluramine, produces hypothermia in rodents by an, as yet, uncharacterized mechanism." | 3.72 | Fenfluramine-induced hypothermia is associated with cutaneous dilation in conscious rats. ( Subramanian, S; Vollmer, RR, 2004) |
| "Flunarizine is considered to be a calcium channel antagonist; therefore this study was aimed at investigating the effect of flunarizine (given in single doses of 5, 10 and 20 mg/kg p." | 1.28 | Some central pharmacological effects of the calcium channel antagonist flunarizine. ( Czyrak, A; Maj, J; Mogilnicka, E, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, JX | 1 |
| Koek, W | 1 |
| France, CP | 1 |
| Jacobsen, JP | 1 |
| Siesser, WB | 1 |
| Sachs, BD | 1 |
| Peterson, S | 1 |
| Cools, MJ | 1 |
| Setola, V | 1 |
| Folgering, JH | 1 |
| Flik, G | 1 |
| Caron, MG | 1 |
| Gonzalez, LE | 1 |
| Parada, MA | 1 |
| Tucci, S | 1 |
| Teneud, L | 1 |
| Overstreet, DH | 1 |
| Hernandez, L | 1 |
| Itzhak, Y | 1 |
| Ali, SF | 1 |
| Anderson, KL | 1 |
| Subramanian, S | 1 |
| Vollmer, RR | 1 |
| Cryan, JF | 1 |
| Harkin, A | 1 |
| Naughton, M | 1 |
| Kelly, JP | 1 |
| Leonard, BE | 1 |
| Czyrak, A | 1 |
| Mogilnicka, E | 1 |
| Maj, J | 1 |
| Srimal, RC | 1 |
| Singh, HK | 1 |
| Dhawan, BN | 1 |
8 other studies available for fenfluramine and Hypothermia, Accidental
| Article | Year |
|---|---|
Food restriction and streptozotocin differentially modify sensitivity to the hypothermic effects of direct- and indirect-acting serotonin receptor agonists in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Body Weight; Diet; DOM 2,5-Dimeth | 2009 |
Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.
Topics: Animals; Behavior, Animal; Biomarkers; Corticosterone; Depression; Disease Models, Animal; Extracell | 2012 |
A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Brain; Breeding; Cerebral Cor | 2003 |
Fenfluramine-induced serotonergic neurotoxicity in mice: lack of neuroprotection by inhibition/ablation of nNOS.
Topics: Animals; Biomarkers; Body Temperature; Carrier Proteins; Corpus Striatum; Enzyme Inhibitors; Fenflur | 2003 |
Fenfluramine-induced hypothermia is associated with cutaneous dilation in conscious rats.
Topics: Animals; Body Temperature; Fenfluramine; Fluoxetine; Hypothermia; Male; Nicotinic Antagonists; Oxyge | 2004 |
Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Benzofurans; Body Temperature; Cerebral | 2000 |
Some central pharmacological effects of the calcium channel antagonist flunarizine.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Body Temperature Regulation; Dopamine; Dopamine Antagonis | 1991 |
Experimental evidence for imipramine like activity of fenfluramine.
Topics: Animals; Avoidance Learning; Blepharoptosis; Blood Pressure; Body Temperature; Cats; Columbidae; Dru | 1970 |