fenfluramine has been researched along with Hypertriglyceridemia in 5 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Hypertriglyceridemia: A condition of elevated levels of TRIGLYCERIDES in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "D-fenfluramine treatment markedly improved the maximum relaxant response of aortic rings to acetylcholine, indicating improvement of the defective endothelium-derived relaxation factor system." | 5.30 | Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine. ( Amy, RM; Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC, 1998) |
| "D-fenfluramine treatment markedly improved the maximum relaxant response of aortic rings to acetylcholine, indicating improvement of the defective endothelium-derived relaxation factor system." | 1.30 | Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine. ( Amy, RM; Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fields, M | 1 |
| Lewis, CG | 1 |
| Russell, JC | 1 |
| Dolphin, PJ | 1 |
| Graham, SE | 1 |
| Amy, RM | 1 |
| Brindley, DN | 1 |
| Drain, P | 1 |
| Brun, LD | 1 |
| Bielmann, P | 1 |
| Gagne, C | 1 |
| Moorjani, S | 1 |
| Nadeau, A | 1 |
| Lupien, PJ | 1 |
1 review available for fenfluramine and Hypertriglyceridemia
| Article | Year |
|---|---|
[Benfluorex (Mediator): non-insulin-dependent diabetes and hypertriglyceridemia].
Topics: Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hypertriglyceridemia | 1998 |
1 trial available for fenfluramine and Hypertriglyceridemia
| Article | Year |
|---|---|
Effects of fenfluramine in hypertriglyceridemic obese subjects.
Topics: Adult; Apoproteins; Clinical Trials as Topic; Double-Blind Method; Female; Fenfluramine; Humans; Hyp | 1988 |
3 other studies available for fenfluramine and Hypertriglyceridemia
| Article | Year |
|---|---|
Benfluorex, a hypotriglyceridemic drug, reduces lipid peroxidation and alleviates adverse metabolic complications of copper deficiency.
Topics: Amylases; Analysis of Variance; Animals; Body Weight; Cohort Studies; Copper; Diet; Fasting; Fenflur | 1997 |
Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine.
Topics: Acetylcholine; Animals; Aorta; Aorta, Thoracic; Aortic Diseases; Appetite Depressants; Arteriosclero | 1998 |
Benfluorex: what use? A second look. Poor assessment file.
Topics: Acids, Acyclic; Appetite Depressants; Clinical Trials as Topic; Drug Evaluation; Fenfluramine; Franc | 1998 |