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fenfluramine and Hypertriglyceridemia

fenfluramine has been researched along with Hypertriglyceridemia in 5 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Hypertriglyceridemia: A condition of elevated levels of TRIGLYCERIDES in the blood.

Research Excerpts

ExcerptRelevanceReference
"D-fenfluramine treatment markedly improved the maximum relaxant response of aortic rings to acetylcholine, indicating improvement of the defective endothelium-derived relaxation factor system."5.30Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine. ( Amy, RM; Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC, 1998)
"D-fenfluramine treatment markedly improved the maximum relaxant response of aortic rings to acetylcholine, indicating improvement of the defective endothelium-derived relaxation factor system."1.30Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine. ( Amy, RM; Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC, 1998)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fields, M1
Lewis, CG1
Russell, JC1
Dolphin, PJ1
Graham, SE1
Amy, RM1
Brindley, DN1
Drain, P1
Brun, LD1
Bielmann, P1
Gagne, C1
Moorjani, S1
Nadeau, A1
Lupien, PJ1

Reviews

1 review available for fenfluramine and Hypertriglyceridemia

ArticleYear
[Benfluorex (Mediator): non-insulin-dependent diabetes and hypertriglyceridemia].
    Journees annuelles de diabetologie de l'Hotel-Dieu, 1998

    Topics: Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hypertriglyceridemia

1998

Trials

1 trial available for fenfluramine and Hypertriglyceridemia

ArticleYear
Effects of fenfluramine in hypertriglyceridemic obese subjects.
    International journal of obesity, 1988, Volume: 12, Issue:5

    Topics: Adult; Apoproteins; Clinical Trials as Topic; Double-Blind Method; Female; Fenfluramine; Humans; Hyp

1988

Other Studies

3 other studies available for fenfluramine and Hypertriglyceridemia

ArticleYear
Benfluorex, a hypotriglyceridemic drug, reduces lipid peroxidation and alleviates adverse metabolic complications of copper deficiency.
    Nutrition (Burbank, Los Angeles County, Calif.), 1997, Volume: 13, Issue:10

    Topics: Amylases; Analysis of Variance; Animals; Body Weight; Cohort Studies; Copper; Diet; Fasting; Fenflur

1997
Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine.
    Diabetologia, 1998, Volume: 41, Issue:4

    Topics: Acetylcholine; Animals; Aorta; Aorta, Thoracic; Aortic Diseases; Appetite Depressants; Arteriosclero

1998
Benfluorex: what use? A second look. Poor assessment file.
    Prescrire international, 1998, Volume: 7, Issue:34

    Topics: Acids, Acyclic; Appetite Depressants; Clinical Trials as Topic; Drug Evaluation; Fenfluramine; Franc

1998