fenfluramine has been researched along with Hypertension, Renal in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Hypertension, Renal: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stocker, SD | 1 |
| Muldoon, MF | 1 |
| Sved, AF | 1 |
| Vidrio, H | 1 |
| Pardo, EG | 1 |
2 other studies available for fenfluramine and Hypertension, Renal
| Article | Year |
|---|---|
Blunted fenfluramine-evoked prolactin secretion in hypertensive rats.
Topics: Acute Disease; Adrenergic alpha-Agonists; Animals; Blood Pressure; Chronic Disease; Fenfluramine; Hy | 2003 |
Antihypertensive effects of sympathomimetic amines.
Topics: Amines; Amphetamine; Animals; Blood Pressure; Depression, Chemical; Dogs; Ephedrine; Female; Fenflur | 1973 |