fenfluramine has been researched along with Hypersensitivity in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In idiopathic headache (IH) sufferers, phenylephrine and fenfluramine induce a pupillary dilatation respectively greater and lesser than in controls." | 3.65 | Adrenergic supersensitivity of the pupil in idiopathic headache. ( Fanciullacci, M; Galli, P; Pietrini, U; Sicuteri, F, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Panconesi, A | 1 |
| Sicuteri, R | 1 |
| Fanciullacci, M | 1 |
| Galli, P | 1 |
| Pietrini, U | 1 |
| Sicuteri, F | 1 |
| Wilson, CW | 1 |
2 reviews available for fenfluramine and Hypersensitivity
| Article | Year |
|---|---|
Headache induced by serotonergic agonists--a key to the interpretation of migraine pathogenesis?
Topics: Animals; Fenfluramine; Headache; Humans; Hypersensitivity; Piperazines; Receptors, Serotonin; Seroto | 1997 |
Clinical pharmacological aspects of ascorbic acid.
Topics: Administration, Oral; Aged; Antigen-Antibody Reactions; Ascorbic Acid; Aspirin; Child; Common Cold; | 1975 |
1 other study available for fenfluramine and Hypersensitivity
| Article | Year |
|---|---|
Adrenergic supersensitivity of the pupil in idiopathic headache.
Topics: Adult; Female; Fenfluramine; Headache; Humans; Hypersensitivity; Iris; Male; Middle Aged; Phenylephr | 1977 |