fenfluramine has been researched along with Hyperphagia in 12 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Hyperphagia: Ingestion of a greater than optimal quantity of food.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine." | 7.67 | Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. ( Bianchetti, A; Miranda, GF; Poggesi, E; Samanin, R; Unkovic, J, 1988) |
| "Various animal models of hyperphagia and obesity have made possible the study of the effect on food intake of dexfenfluramine, an agent which both inhibits reuptake and stimulates release of 5 HT." | 4.77 | [Serotonin, food intake and body weight]. ( Rowland, NE; Souquet, AM, 1989) |
| "The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine." | 3.67 | Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. ( Bianchetti, A; Miranda, GF; Poggesi, E; Samanin, R; Unkovic, J, 1988) |
| "Dexfenfluramine also has an original effect on some food intake disorders." | 2.38 | [Dexfenfluramine and feeding behavior. Clinical and pharmacoclinical studies]. ( Fantino, M, 1989) |
| "Increased research focusing on the eating disorders has put the clinician on firmer ground when choosing appropriate psychopharmacologic treatments." | 2.37 | Pharmacologic treatment of eating disorders. ( Gwirtsman, H; Jimerson, DC; Kaye, W; Weintraub, M, 1984) |
| " The hypothesis is proposed that this treatment is successful because of the dual and balanced increase in the bioavailability of the neurotransmitters, dopamine and serotonin, in the nucleus accumbens." | 1.29 | Combined dopamine and serotonin agonists: a synergistic approach to alcoholism and other addictive behaviors. ( Hitzig, P, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nonogaki, K | 1 |
| Nozue, K | 1 |
| Oka, Y | 1 |
| Gwirtsman, H | 1 |
| Kaye, W | 1 |
| Weintraub, M | 1 |
| Jimerson, DC | 1 |
| Grignaschi, G | 1 |
| Sironi, F | 1 |
| Samanin, R | 2 |
| Hitzig, P | 1 |
| Dourish, CT | 1 |
| Jordaan, GP | 1 |
| Roberts, MC | 1 |
| Emsley, RA | 1 |
| Miranda, GF | 1 |
| Poggesi, E | 1 |
| Bianchetti, A | 1 |
| Unkovic, J | 1 |
| Fantino, M | 1 |
| Rowland, NE | 1 |
| Souquet, AM | 1 |
| Pope, HG | 1 |
| Hudson, JI | 1 |
| Carruba, MO | 1 |
| Mantegazza, P | 1 |
| Memo, M | 1 |
| Missale, C | 1 |
| Pizzi, M | 1 |
| Spano, PF | 1 |
| Robinson, PH | 1 |
| Checkley, SA | 1 |
| Russell, GF | 1 |
5 reviews available for fenfluramine and Hyperphagia
| Article | Year |
|---|---|
Pharmacologic treatment of eating disorders.
Topics: Anorexia Nervosa; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricyclic; Central | 1984 |
Multiple serotonin receptors: opportunities for new treatments for obesity?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Appetite Depressants; Fenfluramine; Humans; Hyperph | 1995 |
[Dexfenfluramine and feeding behavior. Clinical and pharmacoclinical studies].
Topics: Animals; Depression; Feeding Behavior; Fenfluramine; Humans; Hyperphagia; Models, Biological; Obesit | 1989 |
[Serotonin, food intake and body weight].
Topics: Animals; Body Weight; Disease Models, Animal; Eating; Feeding Behavior; Fenfluramine; Humans; Hyperp | 1989 |
Antidepressant drug therapy for bulimia: current status.
Topics: Antidepressive Agents; Bupropion; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method | 1986 |
2 trials available for fenfluramine and Hyperphagia
| Article | Year |
|---|---|
Antidepressant drug therapy for bulimia: current status.
Topics: Antidepressive Agents; Bupropion; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method | 1986 |
Suppression of eating by fenfluramine in patients with bulimia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Depression, Chemical; Eating; Feeding and Eating Disorders; Fem | 1985 |
6 other studies available for fenfluramine and Hyperphagia
| Article | Year |
|---|---|
Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice.
Topics: Agouti Signaling Protein; Animals; Blood Glucose; Body Weight; Caloric Restriction; Eating; Fenflura | 2006 |
The 5-HT1B receptor mediates the effect of d-fenfluramine on eating caused by intra-hypothalamic injection of neuropeptide Y.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Drug Interactions; Eating; Ergolines; Fenfluram | 1995 |
Combined dopamine and serotonin agonists: a synergistic approach to alcoholism and other addictive behaviors.
Topics: Adult; Alcohol Deterrents; Alcoholism; Dopamine Agents; Drug Synergism; Female; Fenfluramine; Humans | 1993 |
Serotonergic agents in the treatment of hypothalamic obesity syndrome: a case report.
Topics: Adult; Body Weight; Brain Damage, Chronic; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetin | 1996 |
Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine.
Topics: Animals; Appetite Depressants; Body Weight; Diet; Dogs; Eating; Feeding and Eating Disorders; Female | 1988 |
Peripheral and central mechanisms of action of serotoninergic anorectic drugs.
Topics: Animals; Appetite Depressants; Brain; Feeding Behavior; Fenfluramine; Hyperphagia; Male; Nervous Sys | 1986 |