Page last updated: 2024-10-27

fenfluramine and Hypercholesterolemia

fenfluramine has been researched along with Hypercholesterolemia in 3 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's2 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Delva, NJ1
Matthews, DR1
Cowen, PJ1
Derby, LE1
Myers, MW1
Jick, H1
Tomlinson, SA1
Lines, JG1
Greenfield, MA1

Trials

1 trial available for fenfluramine and Hypercholesterolemia

ArticleYear
The effect of fenfluramine on obesity and plasma lipids of patients with renal allografts.
    Postgraduate medical journal, 1975, Volume: 51 Suppl 1

    Topics: Body Weight; Clinical Trials as Topic; Female; Fenfluramine; Humans; Hypercholesterolemia; Kidney Tr

1975

Other Studies

2 other studies available for fenfluramine and Hypercholesterolemia

ArticleYear
Brain serotonin (5-HT) neuroendocrine function in patients taking cholesterol-lowering drugs.
    Biological psychiatry, 1996, Jan-15, Volume: 39, Issue:2

    Topics: Analysis of Variance; Anticholesteremic Agents; Brain; Case-Control Studies; Fenfluramine; Humans; H

1996
Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke.
    British journal of clinical pharmacology, 1999, Volume: 47, Issue:5

    Topics: Aged; Appetite Depressants; Body Mass Index; Case-Control Studies; Cerebrovascular Disorders; Cohort

1999