fenfluramine has been researched along with Hypercholesterolemia in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Delva, NJ | 1 |
| Matthews, DR | 1 |
| Cowen, PJ | 1 |
| Derby, LE | 1 |
| Myers, MW | 1 |
| Jick, H | 1 |
| Tomlinson, SA | 1 |
| Lines, JG | 1 |
| Greenfield, MA | 1 |
1 trial available for fenfluramine and Hypercholesterolemia
| Article | Year |
|---|---|
The effect of fenfluramine on obesity and plasma lipids of patients with renal allografts.
Topics: Body Weight; Clinical Trials as Topic; Female; Fenfluramine; Humans; Hypercholesterolemia; Kidney Tr | 1975 |
2 other studies available for fenfluramine and Hypercholesterolemia
| Article | Year |
|---|---|
Brain serotonin (5-HT) neuroendocrine function in patients taking cholesterol-lowering drugs.
Topics: Analysis of Variance; Anticholesteremic Agents; Brain; Case-Control Studies; Fenfluramine; Humans; H | 1996 |
Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke.
Topics: Aged; Appetite Depressants; Body Mass Index; Case-Control Studies; Cerebrovascular Disorders; Cohort | 1999 |