fenfluramine has been researched along with Heroin Abuse in 6 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twelve heroin-dependent subjects with antisocial personality disorder (ASPD) (group A), 18 heroin-dependent subjects without other Axis I and II pathologies (group B) were included among abstinent substance abusers." | 1.32 | Neuroendocrine correlates of antisocial personality disorder in abstinent heroin-dependent subjects. ( Brambilla, F; Bussandri, M; Caccavari, R; Delsignore, R; Gerra, G; Moi, G; Zaimovic, A, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gerra, G | 4 |
| Zaimovic, A | 4 |
| Moi, G | 1 |
| Bussandri, M | 1 |
| Delsignore, R | 4 |
| Caccavari, R | 3 |
| Brambilla, F | 3 |
| Higgins, GA | 1 |
| Wang, Y | 1 |
| Sellers, EM | 1 |
| Fertonani, G | 2 |
| Tagliavini, P | 1 |
| Maestri, D | 1 |
| Avanzini, P | 2 |
| Rota-Graziosi, I | 1 |
| Lucchini, A | 1 |
| Zambelli, U | 1 |
| Baroni, MC | 1 |
| Laviola, G | 1 |
| Macchia, T | 1 |
| Levin, A | 1 |
1 trial available for fenfluramine and Heroin Abuse
| Article | Year |
|---|---|
Hostility in heroin abusers subtypes: fluoxetine and naltrexone treatment.
Topics: Adult; Aggression; Antidepressive Agents, Second-Generation; Fenfluramine; Fluoxetine; Heroin Depend | 1995 |
5 other studies available for fenfluramine and Heroin Abuse
| Article | Year |
|---|---|
Neuroendocrine correlates of antisocial personality disorder in abstinent heroin-dependent subjects.
Topics: Adrenergic alpha-Agonists; Adult; Antisocial Personality Disorder; Brain; Bromocriptine; Case-Contro | 2003 |
Preliminary findings with the indirect 5-HT agonist dexfenfluramine on heroin discrimination and self-administration in rats.
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Fenfluramine; Generalization, Stimu | 1993 |
Serotonin function in detoxified heroin abusers: prolactin and cortisol responses to fenfluramine challenge.
Topics: Adult; Aggression; Antisocial Personality Disorder; Depressive Disorder; Fenfluramine; Heroin Depend | 1995 |
Neuroendocrine correlates of depression in abstinent heroin-dependent subjects.
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Biomarkers; Brain; Bromocriptine; Case-Contr | 2000 |
Drug-taking patterns in the National Service.
Topics: Cannabis; Fenfluramine; Heroin Dependence; Humans; Lysergic Acid Diethylamide; Military Medicine; So | 1973 |