fenfluramine has been researched along with Heritable Pulmonary Arterial Hypertension in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Benfluorex was marketed in France until 2009, despite its similar pharmacological properties with fenfluramine and its derivatives known to be a cause of pulmonary arterial hypertension (PAH)." | 5.38 | Pulmonary hypertension associated with benfluorex exposure. ( Bergot, E; Bourdin, A; Chaumais, MC; Cottin, V; Dromer, C; Frachon, I; Habib, G; Humbert, M; Jaïs, X; Lamblin, N; Montani, D; Pison, C; Poubeau, P; Prevot, G; Reynaud-Gaubert, M; Sanchez, O; Savale, L; Simonneau, G; Sitbon, O; Tubert-Bitter, P, 2012) |
| "Benfluorex was marketed in France until 2009, despite its similar pharmacological properties with fenfluramine and its derivatives known to be a cause of pulmonary arterial hypertension (PAH)." | 1.38 | Pulmonary hypertension associated with benfluorex exposure. ( Bergot, E; Bourdin, A; Chaumais, MC; Cottin, V; Dromer, C; Frachon, I; Habib, G; Humbert, M; Jaïs, X; Lamblin, N; Montani, D; Pison, C; Poubeau, P; Prevot, G; Reynaud-Gaubert, M; Sanchez, O; Savale, L; Simonneau, G; Sitbon, O; Tubert-Bitter, P, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Souza, R | 1 |
| Jardim, C | 1 |
| Humbert, M | 2 |
| Savale, L | 1 |
| Chaumais, MC | 1 |
| Cottin, V | 1 |
| Bergot, E | 1 |
| Frachon, I | 1 |
| Prevot, G | 1 |
| Pison, C | 1 |
| Dromer, C | 1 |
| Poubeau, P | 1 |
| Lamblin, N | 1 |
| Habib, G | 1 |
| Reynaud-Gaubert, M | 1 |
| Bourdin, A | 1 |
| Sanchez, O | 1 |
| Tubert-Bitter, P | 1 |
| Jaïs, X | 1 |
| Montani, D | 1 |
| Sitbon, O | 1 |
| Simonneau, G | 1 |
3 other studies available for fenfluramine and Heritable Pulmonary Arterial Hypertension
| Article | Year |
|---|---|
Idiopathic pulmonary arterial hypertension.
Topics: Aminorex; Antihypertensive Agents; Appetite Depressants; Bosentan; Dasatinib; Epoprostenol; Familial | 2013 |
Benfluorex: how many deaths?
Topics: Appetite Depressants; Familial Primary Pulmonary Hypertension; Fenfluramine; France; Heart Valve Dis | 2011 |
Pulmonary hypertension associated with benfluorex exposure.
Topics: Adult; Aged; Appetite Depressants; Familial Primary Pulmonary Hypertension; Female; Fenfluramine; Hu | 2012 |