fenfluramine has been researched along with Heart Valve Diseases in 155 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
| Excerpt | Relevance | Reference |
|---|---|---|
| " This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylpropion, mazindol, and phentermine), as well as over-the-counter adrenergic drugs (phenylpropanolamine and ephedrine); recent clinical studies documenting the safety and efficacy of a new medication for obesity treatment, sibutramine, recently approved by the Food and Drug Administration for long-term use; and recent studies characterizing the valvulopathy associated with fenfluramine and dexfenfluramine, serotonergic medications for obesity which have been removed from the markets." | 8.80 | Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity. ( Ryan, DH, 2000) |
| "The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman." | 7.78 | Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012) |
| "Benfluorex is a fenfluramine derivative which has been marketed between 1976 and 2009." | 5.46 | Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report. ( Banfi, C; Baufreton, C; Bruneval, P; Ennezat, PV; Fouquet, O; Giraud, R; Rousselet, MC, 2017) |
| "Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2." | 5.36 | Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010) |
| "To determine the echocardiographic changes over time of valvular heart lesions in patients who took the weight loss drugs fenfluramine and phentermine." | 5.09 | Echocardiographic improvement over time after cessation of use of fenfluramine and phentermine. ( Bailey, KR; Connolly, HM; Grogan, M; Hensrud, DD; Jensen, MD; Miller, FA, 1999) |
| "From the group of 720 smokers who had originally participated in the smoking cessation therapy trial, 619 women were enrolled; data from 530 (276 in the fenfluramine group and 254 in the placebo group) were evaluable." | 5.09 | Echocardiographic examination of women previously treated with fenfluramine: long-term follow-up of a randomized, double-blind, placebo-controlled trial. ( Balady, GJ; Bowen, DJ; Constantine, G; Davidoff, R; Davis, KD; McTiernan, A; Mendes, LA; Rudolph, RE, 2001) |
| " This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylpropion, mazindol, and phentermine), as well as over-the-counter adrenergic drugs (phenylpropanolamine and ephedrine); recent clinical studies documenting the safety and efficacy of a new medication for obesity treatment, sibutramine, recently approved by the Food and Drug Administration for long-term use; and recent studies characterizing the valvulopathy associated with fenfluramine and dexfenfluramine, serotonergic medications for obesity which have been removed from the markets." | 4.80 | Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity. ( Ryan, DH, 2000) |
| "The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman." | 3.78 | Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012) |
| " As a derivative of fenfluramine with an appetite suppressant action, benfluorex is preferentially used in overweight patients." | 3.75 | Fenfluramine-like cardiovascular side-effects of benfluorex. ( Boutet, K; Carlhant-Kowalski, D; Frachon, I; Gut-Gobert, C; Humbert, M; Jobic, Y; Leroyer, C; Simonneau, G; Sitbon, O, 2009) |
| "To assess weight loss, as well as the prevalence of valvular heart disease, in 21 obese women who completed 2 years of treatment by fenfluramine and phentermine (fen-phen) in June 1997." | 3.70 | The fen-phen finale: a study of weight loss and valvular heart disease. ( Aber, JL; Berkowitz, RI; Foster, GD; Silvestry, F; St John Sutton, MG; Stunkard, AJ; Vogt, RA; Wadden, TA, 1998) |
| "22 severe binge eaters, 17 moderate binge eaters, and 16 non-binge eaters received phentermine resin 15mg/day and dl-fenfluramine 20mg three times daily over a 6 month period for weight loss." | 3.70 | Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters. ( Alger, SA; Cerulli, J; Fein, S; Howard, L; Malone, M, 1999) |
| "Serotoninergic appetite-suppressant drugs, fenfluramine and dexfenfluramine, were withdrawn from the market in September 1997 on account of two major cardiopulmonary complications: primary pulmonary hypertension and valvular regurgitation." | 3.70 | [Appetite suppressants and heart valve disorders]. ( Adams, C; Cohen, A, 1999) |
| "To evaluate cardiovascular status and the prevalence of valvular abnormalities, as assessed by clinical cardiovascular parameters and echocardiography, in patients treated for obesity with dexfenfluramine or phentermine/fenfluramine." | 3.70 | Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine. ( Constantine, G; Davis, KD; Gardin, JM; Leung, C; Reid, CL; Schumacher, D, 2000) |
| "Fenfluramine, which was previously approved as a weight loss drug, was withdrawn in 1997 when reports of cardiac valvulopathy emerged." | 2.94 | Cardiovascular safety of fenfluramine in the treatment of Dravet syndrome: Analysis of an ongoing long-term open-label safety extension study. ( Agarwal, A; Farfel, G; Galer, BS; Keane, MG; Lai, WW; Pringsheim, M; Wong, PC, 2020) |
| "Aortic regurgitation was detected in 18 subjects, mitral regurgitation in 3 subjects, and both aortic and mitral regurgitation in 1 subject; no one had severe regurgitation." | 2.70 | Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs. ( Blackburn, GL; Burger, AJ; Charlamb, MJ; Notarianni, M; Sherman, HB; Singh, S, 2001) |
| " Further studies should be conducted to determine the subsequent course of benfluorex-induced VHD and PAH, and to identify genetic, biological and clinical factors that determine individual susceptibility to developing such adverse effects." | 2.50 | Adverse effects of benfluorex on heart valves and pulmonary circulation. ( Andréjak, M; Maréchaux, S; Peltier, M; Szymanski, C; Tribouilloy, C, 2014) |
| " Receptorome screening has implicated N-deethylation of fenfluramine and serotonin 5-hydroxy-t-ryptamine 2B receptors in the adverse effects of the drug; subsequent studies corroborated this finding." | 2.43 | Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'. ( Roth, BL; Setola, V, 2005) |
| "Obesity is a chronic disorder that is associated with significant co-morbidity and early mortality." | 2.42 | Anorexigen-induced cardiac valvulopathy and female gender. ( Gross, SB; Naqvi, TZ, 2003) |
| "Patients with Dravet syndrome who completed one of three phase 3 clinical trials of fenfluramine could enroll in the open-label extension (OLE) study (NCT02823145)." | 1.72 | Long-term cardiovascular safety of fenfluramine in patients with Dravet syndrome treated for up to 3 years: Findings from serial echocardiographic assessments. ( Agarwal, A; Farfel, GM; Galer, BS; Gammaitoni, AR; Pinto, FJ; Wong, PC, 2022) |
| "Benfluorex is a fenfluramine derivative which has been marketed between 1976 and 2009." | 1.46 | Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report. ( Banfi, C; Baufreton, C; Bruneval, P; Ennezat, PV; Fouquet, O; Giraud, R; Rousselet, MC, 2017) |
| "Fenfluramine has been associated with an increased risk of pulmonary hypertension and valvular disease." | 1.37 | Mitral and aortic valvular disease associated with benfluorex use. ( Castellant, P; Etienne, Y; Fatemi, M; Frachon, I; Jobic, Y; Quintin-Roué, I, 2011) |
| "Benfluorex has the same adverse effects as those that led to the withdrawal of amphetamine appetite suppressants such as fenfluramine." | 1.36 | Benfluorex: increasing reports of valve disorders. ( , 2010) |
| "Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2." | 1.36 | Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010) |
| "Pulmonary hypertension was strongly associated with MR but not AR." | 1.35 | Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals. ( Allen, MR; Dahl, CF; Hopkins, PN; Urie, PM, 2008) |
| "Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant until it was reported to be associated with valvular heart disease." | 1.31 | Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine. ( Abbaszade, I; Brown, BS; Burn, TC; Corjay, MH; Fitzgerald, LW; Hartig, PR; Hollis, GF; Hollis, JM; Largent, BL; Link, JR; Meunier, PC; Patterson, JP; Robertson, DW; Robichaud, AJ; Sun, JH; Valentine, PA, 2000) |
| "The most common finding was mild aortic regurgitation." | 1.31 | Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience. ( Connolly, HM; Grogan, M; Miller, FA; Teramae, CY, 2000) |
| "To determine whether the severity of valvulopathy was associated with the dosage of fenfluramine taken by fenfluramine-phentermine users with valvulopathy." | 1.30 | Dose-effect of fenfluramine use on the severity of valvular heart disease among fen-phen patients with valvulopathy. ( Bowman, BA; Graham, DJ; Green, L; Li, R; Serdula, MK; Williamson, DF, 1999) |
| "If mild or greater aortic or mitral regurgitation is present, antibiotic prophylaxis against endocarditis is recommended." | 1.30 | Prevention of infective endocarditis associated with dental treatment and other medical interventions. National Heart Foundation. ( Ellis-Pegler, RB; Hay, KD; Lang, SD; Neutze, JM; Swinburn, BA, 1999) |
| "Marked obesity is an independent risk factor for multi-system morbidity." | 1.30 | [Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants]. ( Goldstein, SE; Levy, Y; Shoenfeld, Y, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 69 (44.52) | 18.2507 |
| 2000's | 47 (30.32) | 29.6817 |
| 2010's | 36 (23.23) | 24.3611 |
| 2020's | 3 (1.94) | 2.80 |
| Authors | Studies |
|---|---|
| Agarwal, A | 2 |
| Farfel, GM | 1 |
| Gammaitoni, AR | 1 |
| Wong, PC | 2 |
| Pinto, FJ | 1 |
| Galer, BS | 2 |
| Bender, AM | 1 |
| Parr, LC | 1 |
| Livingston, WB | 1 |
| Lindsley, CW | 1 |
| Merryman, WD | 1 |
| Lai, WW | 1 |
| Farfel, G | 1 |
| Pringsheim, M | 2 |
| Keane, MG | 3 |
| Schoonjans, AS | 1 |
| Marchau, F | 1 |
| Paelinck, BP | 1 |
| Lagae, L | 1 |
| Gammaitoni, A | 1 |
| Ceulemans, B | 1 |
| Goldberg, E | 1 |
| Grau, JB | 1 |
| Fortier, JH | 1 |
| Salvati, E | 1 |
| Levy, RJ | 2 |
| Ferrari, G | 1 |
| Dyer, O | 1 |
| Rajamannan, NM | 1 |
| Szymanski, C | 2 |
| Andréjak, M | 1 |
| Peltier, M | 1 |
| Maréchaux, S | 3 |
| Tribouilloy, C | 3 |
| Rusinaru, D | 1 |
| Jobic, Y | 7 |
| Ederhy, S | 1 |
| Donal, E | 1 |
| Réant, P | 1 |
| Arnalsteen, E | 1 |
| Boulanger, J | 1 |
| Garban, T | 1 |
| Ennezat, PV | 3 |
| Jeu, A | 1 |
| Plurien, F | 1 |
| Bruneval, P | 2 |
| Iung, B | 1 |
| Le Ven, F | 2 |
| Alavi, Z | 1 |
| Etienne, Y | 4 |
| Didier, R | 1 |
| Porcher, R | 1 |
| Baufreton, C | 1 |
| Rousselet, MC | 1 |
| Fouquet, O | 1 |
| Giraud, R | 1 |
| Banfi, C | 1 |
| Dahl, CF | 1 |
| Allen, MR | 1 |
| Urie, PM | 1 |
| Hopkins, PN | 1 |
| Boutet, K | 1 |
| Frachon, I | 3 |
| Gut-Gobert, C | 1 |
| Leroyer, C | 2 |
| Carlhant-Kowalski, D | 1 |
| Sitbon, O | 1 |
| Simonneau, G | 1 |
| Humbert, M | 2 |
| Droogmans, S | 2 |
| Kerkhove, D | 1 |
| Cosyns, B | 2 |
| Van Camp, G | 2 |
| Rothman, RB | 4 |
| Baumann, MH | 2 |
| Connolly, JM | 1 |
| Bakay, MA | 1 |
| Fulmer, JT | 1 |
| Gorman, RC | 1 |
| Gorman, JH | 1 |
| Oyama, MA | 1 |
| Bhattacharyya, S | 1 |
| Schapira, AH | 1 |
| Mikhailidis, DP | 1 |
| Davar, J | 1 |
| Le Gal, G | 1 |
| Gueffet, JP | 2 |
| Piriou, N | 1 |
| Trochu, JN | 1 |
| Weill, A | 1 |
| Païta, M | 1 |
| Tuppin, P | 1 |
| Fagot, JP | 1 |
| Neumann, A | 1 |
| Simon, D | 1 |
| Ricordeau, P | 1 |
| Montastruc, JL | 1 |
| Allemand, H | 1 |
| Hajjo, R | 1 |
| Grulke, CM | 1 |
| Golbraikh, A | 1 |
| Setola, V | 3 |
| Huang, XP | 1 |
| Roth, BL | 4 |
| Tropsha, A | 1 |
| Habib, G | 2 |
| Eicher, JC | 1 |
| Blanchard-Lemoine, B | 1 |
| Rousseau, J | 1 |
| Hénon, P | 1 |
| Mullard, A | 1 |
| Nau, JY | 2 |
| Fatemi, M | 1 |
| Castellant, P | 1 |
| Quintin-Roué, I | 1 |
| Boudes, A | 1 |
| Lavoute, C | 1 |
| Avierinos, JF | 1 |
| Le Dolley, Y | 1 |
| Villacampa, C | 1 |
| Salem, A | 1 |
| Loundou, AD | 1 |
| Michel, N | 1 |
| Renard, S | 1 |
| Surapaneni, P | 1 |
| Vinales, KL | 1 |
| Najib, MQ | 1 |
| Chaliki, HP | 1 |
| Fournier, A | 1 |
| Zureik, M | 1 |
| Ayme-Dietrich, E | 1 |
| Lawson, R | 1 |
| Gasser, B | 1 |
| Dallemand, R | 1 |
| Bischoff, N | 1 |
| Monassier, L | 1 |
| Benkimoun, P | 1 |
| Deltour, N | 1 |
| Coste, M | 1 |
| Tupinon-Mathieu, I | 1 |
| Derumeaux, G | 1 |
| Ernande, L | 1 |
| Serusclat, A | 1 |
| Servan, E | 1 |
| Bruckert, E | 1 |
| Rousset, H | 1 |
| Senn, S | 1 |
| Van Gaal, L | 1 |
| Picandet, B | 1 |
| Gavini, F | 1 |
| Moulin, P | 1 |
| Watson, R | 1 |
| Acar, J | 1 |
| Vaughan, SF | 1 |
| Loke, YK | 1 |
| Derry, S | 1 |
| Pritchard-Copley, A | 1 |
| Seghatol, FF | 1 |
| Rigolin, VH | 1 |
| Roldan, CA | 1 |
| Gelgand, EA | 1 |
| Decker, P | 1 |
| Prasad, A | 1 |
| Shively, BK | 1 |
| Gross, SB | 3 |
| Lepor, NE | 1 |
| Sachdev, M | 1 |
| Miller, WC | 1 |
| Ryan, T | 1 |
| Jollis, JG | 1 |
| Rafel Ribera, J | 1 |
| Casañas Muñoz, R | 1 |
| Anguera Ferrando, N | 1 |
| Batalla Sahún, N | 1 |
| Castro Cels, A | 1 |
| Pujadas Capmany, R | 1 |
| Naqvi, TZ | 1 |
| Hufeisen, SJ | 2 |
| Grande-Allen, KJ | 1 |
| Vesely, I | 1 |
| Glennon, RA | 1 |
| Blough, B | 1 |
| Rice, B | 1 |
| Hess, MA | 1 |
| Schachter, M | 1 |
| Smith, DA | 1 |
| Schmid, EF | 1 |
| Whigham, LD | 1 |
| Dhurandhar, NV | 1 |
| Rahko, PS | 1 |
| Atkinson, RL | 1 |
| Greffe, G | 1 |
| Chalabreysse, L | 1 |
| Mouly-Bertin, C | 1 |
| Lantelme, P | 1 |
| Thivolet, F | 1 |
| Aulagner, G | 1 |
| Obadia, JF | 1 |
| Donnelly, KB | 1 |
| Nightingale, SL | 1 |
| Connolly, HM | 5 |
| Crary, JL | 2 |
| McGoon, MD | 2 |
| Hensrud, DD | 2 |
| Edwards, BS | 1 |
| Edwards, WD | 1 |
| Schaff, HV | 2 |
| Curfman, GD | 1 |
| Graham, DJ | 2 |
| Green, L | 2 |
| Cannistra, LB | 2 |
| Davis, SM | 1 |
| Bauman, AG | 1 |
| Boughner, DR | 1 |
| SoRelle, R | 2 |
| Brower, V | 1 |
| Kassirer, JP | 1 |
| Angell, M | 1 |
| Josefson, D | 1 |
| Thompson, PD | 1 |
| Kurz, X | 1 |
| Van Ermen, A | 1 |
| Redmon, B | 1 |
| Raatz, S | 1 |
| Bantle, JP | 2 |
| Wolff, FW | 1 |
| Spitzer, WO | 1 |
| Griffen, L | 2 |
| Anchors, M | 2 |
| Hirsch, J | 1 |
| Scheen, AJ | 1 |
| Stahl, SM | 1 |
| Cheng, TO | 3 |
| Wong, J | 1 |
| Reddy, SS | 1 |
| Klein, AL | 1 |
| Aurigemma, GP | 1 |
| Gaasch, WH | 1 |
| Sandrick, KM | 1 |
| Hilsen, K | 1 |
| Davis, S | 1 |
| Iyer, P | 1 |
| Krynicki, PF | 1 |
| Malak, J | 1 |
| Deprez, P | 1 |
| Adam, JF | 1 |
| Alexander, JH | 1 |
| Greenbaum, AB | 1 |
| Hudson, MP | 1 |
| Kong, DF | 1 |
| Miller, JM | 1 |
| Tung, CY | 1 |
| Whellan, DJ | 1 |
| Wadden, TA | 2 |
| Berkowitz, RI | 2 |
| Silvestry, F | 1 |
| Vogt, RA | 1 |
| St John Sutton, MG | 1 |
| Stunkard, AJ | 1 |
| Foster, GD | 2 |
| Aber, JL | 2 |
| Shiffman, MA | 1 |
| Devereux, RB | 1 |
| Cannistra, AJ | 1 |
| Baird, IM | 1 |
| Godeau, P | 1 |
| Cherin, P | 1 |
| Tellier, P | 3 |
| Biron, CR | 1 |
| Wee, CC | 1 |
| Phillips, RS | 1 |
| Aurigemma, G | 1 |
| Erban, S | 1 |
| Kriegel, G | 1 |
| Riley, M | 1 |
| Douglas, PS | 1 |
| Parisi, AF | 1 |
| Williamson, DF | 2 |
| Yanovski, SZ | 1 |
| Shapiro, S | 1 |
| Cowley, G | 1 |
| Springen, K | 1 |
| Tovar, EA | 1 |
| Landa, DW | 1 |
| Borsari, BE | 1 |
| Silvestry, FE | 2 |
| Sutton, MG | 1 |
| St John Sutton, M | 1 |
| Li, R | 1 |
| Serdula, MK | 1 |
| Bowman, BA | 1 |
| Kimmel, SE | 1 |
| Jones, J | 1 |
| Kinman, JL | 1 |
| Beare, J | 1 |
| Sammel, M | 1 |
| Sutton, MS | 1 |
| Strom, BL | 1 |
| Alger, SA | 1 |
| Malone, M | 1 |
| Cerulli, J | 1 |
| Fein, S | 1 |
| Howard, L | 1 |
| Burger, AJ | 2 |
| Sherman, HB | 2 |
| Charlamb, MJ | 2 |
| Kim, J | 1 |
| Asinas, LA | 1 |
| Flickner, SR | 1 |
| Blackburn, GL | 2 |
| Schiller, NB | 1 |
| Pallasch, TJ | 1 |
| Adams, C | 1 |
| Cohen, A | 1 |
| Ellis-Pegler, RB | 1 |
| Hay, KD | 1 |
| Lang, SD | 1 |
| Neutze, JM | 1 |
| Swinburn, BA | 1 |
| Ewalenko, M | 1 |
| Richard, C | 1 |
| Vandenbossche, JL | 1 |
| Grogan, M | 2 |
| Miller, FA | 2 |
| Bailey, KR | 1 |
| Jensen, MD | 1 |
| Asinger, RW | 1 |
| Pollick, C | 1 |
| Fitzgerald, LW | 1 |
| Burn, TC | 1 |
| Brown, BS | 1 |
| Patterson, JP | 1 |
| Corjay, MH | 1 |
| Valentine, PA | 1 |
| Sun, JH | 1 |
| Link, JR | 1 |
| Abbaszade, I | 1 |
| Hollis, JM | 1 |
| Largent, BL | 1 |
| Hartig, PR | 1 |
| Hollis, GF | 1 |
| Meunier, PC | 1 |
| Robichaud, AJ | 1 |
| Robertson, DW | 1 |
| Sniderman, AD | 1 |
| Poston, WS | 1 |
| Foreyt, JP | 1 |
| Gardin, JM | 1 |
| Schumacher, D | 1 |
| Constantine, G | 2 |
| Davis, KD | 2 |
| Leung, C | 1 |
| Reid, CL | 1 |
| Jick, H | 1 |
| Redmon, JB | 1 |
| Raatz, SK | 1 |
| Kwong, CA | 1 |
| Swanson, JE | 1 |
| Teramae, CY | 1 |
| Allen, S | 1 |
| Henderson, J | 1 |
| Goldstein, SE | 1 |
| Levy, Y | 1 |
| Shoenfeld, Y | 1 |
| Wolf, I | 1 |
| Mouallem, M | 1 |
| Farfel, Z | 1 |
| Alexander, RE | 1 |
| Lawless-Liday, C | 1 |
| Force, RW | 1 |
| Savage, JE | 1 |
| Rauser, L | 1 |
| McBride, A | 1 |
| Ryan, DH | 1 |
| Weissman, NJ | 1 |
| Rudin, R | 1 |
| Carpenter, W | 1 |
| Davidoff, R | 1 |
| McTiernan, A | 1 |
| Balady, GJ | 1 |
| Mendes, LA | 1 |
| Rudolph, RE | 1 |
| Bowen, DJ | 1 |
| Lee, TH | 1 |
| Singh, S | 1 |
| Notarianni, M | 1 |
| Caccitolo, JA | 1 |
| Rubenson, DS | 1 |
| Orszulak, TA | 1 |
| Vagelos, R | 1 |
| Jacobs, M | 1 |
| Popp, RL | 1 |
| Liang, D | 1 |
24 reviews available for fenfluramine and Heart Valve Diseases
| Article | Year |
|---|---|
2B Determined: The Future of the Serotonin Receptor 2B in Drug Discovery.
Topics: Drug Discovery; Fenfluramine; Heart Valve Diseases; Humans; Receptor, Serotonin, 5-HT2B; Serotonin | 2023 |
Cardiovascular safety of low-dose fenfluramine in Dravet syndrome: a review of its benefit-risk profile in a new patient population.
Topics: Adult; Appetite Depressants; Dexfenfluramine; Epilepsies, Myoclonic; Fenfluramine; Heart Valve Disea | 2017 |
Drug-related cardiac valve disease.
Topics: Ergot Alkaloids; Fenfluramine; Heart Valve Diseases; Humans; Hypercalcemia; Hyperphosphatemia; Inter | 2013 |
Adverse effects of benfluorex on heart valves and pulmonary circulation.
Topics: Echocardiography; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Hypertension, Pulmonary; | 2014 |
Role of echocardiography in toxic heart valvulopathy.
Topics: Animals; Drug-Related Side Effects and Adverse Reactions; Echocardiography, Doppler, Color; Female; | 2009 |
Serotonergic drugs and valvular heart disease.
Topics: Animals; Fenfluramine; Heart Valve Diseases; Humans; Receptor, Serotonin, 5-HT2B; Serotonin; Seroton | 2009 |
Drug-induced fibrotic valvular heart disease.
Topics: Antiparkinson Agents; Appetite Depressants; Cabergoline; Dexfenfluramine; Dopamine Agonists; Drug Mo | 2009 |
Appetite suppressants and valvular heart disease - a systematic review.
Topics: Appetite Depressants; Clinical Trials as Topic; Cohort Studies; Dexfenfluramine; Fenfluramine; Heart | 2002 |
Appetite suppressants and valvular heart disease.
Topics: Appetite Depressants; Carcinoid Heart Disease; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; | 2002 |
Anorexigen-related cardiopulmonary toxicity.
Topics: Aminorex; Appetite Depressants; Dexfenfluramine; Echocardiography; Fenfluramine; Heart Valve Disease | 2000 |
Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Disease | 2002 |
Anorexigen-induced cardiac valvulopathy and female gender.
Topics: Adult; Appetite Depressants; Dexfenfluramine; Echocardiography; Female; Fenfluramine; Heart Valve Di | 2003 |
Cardiac valvulopathy.
Topics: Antiparkinson Agents; Echocardiography, Doppler, Color; Ergotamine; Fenfluramine; Heart Valve Diseas | 2005 |
Drug withdrawals and the lessons within.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbolines; Colitis, Ischemic; Drug Design; Drug-R | 2006 |
Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.
Topics: Animals; Appetite Depressants; Cardiovascular Diseases; Drug Evaluation, Preclinical; Drug-Related S | 2005 |
Cardiac valvular pathology: comparative pathology and animal models of acquired cardiac valvular diseases.
Topics: Animals; Appetite Depressants; Disease Models, Animal; Dogs; Fenfluramine; Heart Valve Diseases; Hea | 2008 |
Current status of fenfluramine/dexfenfluramine-induced cardiac valvulopathy.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Dexfenfluramine; Drug | 1999 |
Obesity drugs and the heart.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermi | 1999 |
Scientific and legal issues in fenfluramine/dexfenfluramine litigation.
Topics: Anti-Obesity Agents; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulm | 2000 |
Appetite suppressants and cardiac valvulopathy. Current clinical perspectives.
Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pul | 1999 |
[Valvular heart disease and primary pulmonary hypertension associated with fenfluramine-phentermine].
Topics: Appetite Depressants; Cardiomyopathies; Drug Therapy, Combination; Fenfluramine; Heart Valve Disease | 1998 |
Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity.
Topics: Adrenergic Agents; Appetite Depressants; Cyclobutanes; Dexfenfluramine; Dextroamphetamine; Fenfluram | 2000 |
Appetite suppressants and valvular heart disease.
Topics: Age Factors; Appetite Depressants; Dexfenfluramine; Drug Therapy, Combination; Fenfluramine; Heart V | 2001 |
Fenfluramines, idiopathic pulmonary primary hypertension and cardiac valve disorders: facts and artifacts.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Obesity; | 2001 |
6 trials available for fenfluramine and Heart Valve Diseases
| Article | Year |
|---|---|
Cardiovascular safety of fenfluramine in the treatment of Dravet syndrome: Analysis of an ongoing long-term open-label safety extension study.
Topics: Adolescent; Child; Child, Preschool; Double-Blind Method; Electrocardiography; Epilepsies, Myoclonic | 2020 |
Echocardiographic evidence for valvular toxicity of benfluorex: a double-blind randomised trial in patients with type 2 diabetes mellitus.
Topics: Aged; Diabetes Mellitus, Type 2; Echocardiography; Female; Fenfluramine; Glycated Hemoglobin; Heart | 2012 |
Echocardiographic improvement over time after cessation of use of fenfluramine and phentermine.
Topics: Adrenergic Agents; Adult; Appetite Depressants; Body Mass Index; Double-Blind Method; Echocardiograp | 1999 |
Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin.
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fem | 2000 |
Echocardiographic examination of women previously treated with fenfluramine: long-term follow-up of a randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Body Mass Index; Double-Blind Method; Echocardiography; Female; Fenfluramin | 2001 |
Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Boston; Drug Therapy, Combination; Female; Fenflur | 2001 |
125 other studies available for fenfluramine and Heart Valve Diseases
| Article | Year |
|---|---|
Long-term cardiovascular safety of fenfluramine in patients with Dravet syndrome treated for up to 3 years: Findings from serial echocardiographic assessments.
Topics: Adolescent; Child; Child, Preschool; Echocardiography; Epilepsies, Myoclonic; Epileptic Syndromes; F | 2022 |
Serotonin and catecholamines in the development and progression of heart valve diseases.
Topics: Animals; Catecholamines; Disease Progression; Fenfluramine; Heart Valve Diseases; Humans; Neurotrans | 2017 |
France to prosecute its drug regulator and Servier in scandal over diabetes drug.
Topics: Drug and Narcotic Control; Drug Industry; Fenfluramine; France; Fraud; Heart Valve Diseases; Homicid | 2017 |
Fenfluramine-Phentermine is Associated with an Increase in Cellular Proliferation Ex Vivo and In Vitro.
Topics: Animals; Anti-Obesity Agents; Aortic Valve; Cardiotoxicity; Case-Control Studies; Cell Proliferation | 2017 |
Benfluorex and cardiac valve disease: long delay in publication.
Topics: Access to Information; Appetite Depressants; Fenfluramine; Heart Valve Diseases; Heart Valves; Human | 2013 |
Exposure to benfluorex: left heart valve disease very common.
Topics: Echocardiography; Fenfluramine; France; Heart Valve Diseases; Humans; Hypolipidemic Agents; Safety-B | 2013 |
Identifying drug-related disorders: a probabilistic approach.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Probability | 2013 |
Benfluorex: left heart valve disease very common.
Topics: Appetite Depressants; Echocardiography; Fenfluramine; France; Heart Valve Diseases; Humans | 2014 |
Food and Drug Administration criteria for the diagnosis of drug-induced valvular heart disease in patients previously exposed to benfluorex: a prospective multicentre study.
Topics: Aged; Appetite Depressants; Case-Control Studies; Echocardiography, Doppler; Female; Fenfluramine; H | 2015 |
Calcifications in benfluorex-induced valve heart disease: a misknown association.
Topics: Aged; Aortic Valve Insufficiency; Appetite Depressants; Calcinosis; Fenfluramine; Heart Valve Diseas | 2015 |
Drug-Induced- or Rheumatic- Valvular Heart Disease in Patients Exposed to Benfluorex?
Topics: Aged; Appetite Depressants; Female; Fenfluramine; France; Heart Valve Diseases; Humans; Male; Markov | 2016 |
Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report.
Topics: Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Heart Valve Diseases; Heart Valve Prosthe | 2017 |
Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Obesity Agents; Echocardiography; Female; Fenflura | 2008 |
Fenfluramine-like cardiovascular side-effects of benfluorex.
Topics: Appetite Depressants; Cardiovascular Diseases; Diabetes Mellitus; Female; Fenfluramine; Heart Valve | 2009 |
Benfluorex: negative data in France, but still on the market. Neuropsychiatric disorders, pulmonary hypertension and heart valve damage.
Topics: Appetite Depressants; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; N | 2009 |
Fenfluramine disrupts the mitral valve interstitial cell response to serotonin.
Topics: Adult; Aged; Aged, 80 and over; Animals; Cell Proliferation; Cells, Cultured; Dogs; Dose-Response Re | 2009 |
Benfluorex and unexplained valvular heart disease: a case-control study.
Topics: Aged; Case-Control Studies; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents | 2010 |
Benfluorex: increasing reports of valve disorders.
Topics: Appetite Depressants; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; P | 2010 |
Valvular heart disease associated with benfluorex.
Topics: Appetite Depressants; Diuretics; Echocardiography, Doppler, Color; Female; Fenfluramine; Furosemide; | 2010 |
Benfluorex: yet more valve disorders.
Topics: Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents | 2010 |
Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus.
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Databases, Factual; D | 2010 |
Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.
Topics: Algorithms; Binding, Competitive; Databases, Factual; Dexfenfluramine; Drug-Related Side Effects and | 2010 |
Benfluorex: the last chapter of drug-induced valvular heart disease?
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Appetite Depressants; Europe; Fenfluramine; France; | 2011 |
Valvular heart disease associated with benfluorex therapy: results from the French multicentre registry.
Topics: Appetite Depressants; Body Mass Index; Comorbidity; Dose-Response Relationship, Drug; Echocardiograp | 2011 |
Mediator scandal rocks French medical community.
Topics: Appetite Depressants; Drug Industry; Fenfluramine; France; Heart Valve Diseases; Humans; Hypolipidem | 2011 |
[What were the indications for the Mediator in 1979?].
Topics: Anxiety; Appetite Depressants; Diabetes Mellitus, Type 2; Fenfluramine; France; Heart Valve Diseases | 2011 |
Benfluorex: how many deaths?
Topics: Appetite Depressants; Familial Primary Pulmonary Hypertension; Fenfluramine; France; Heart Valve Dis | 2011 |
Mitral and aortic valvular disease associated with benfluorex use.
Topics: Aortic Valve; Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Heart Valve Diseases; Human | 2011 |
[The French are wary of their drugs].
Topics: Appetite Depressants; Body Mass Index; Cause of Death; Drugs, Generic; Fenfluramine; France; Heart V | 2011 |
Valvular heart disease associated with benfluorex therapy: high prevalence in patients with unexplained restrictive valvular heart disease.
Topics: Aortic Valve; Appetite Depressants; Echocardiography, Doppler; Female; Fenfluramine; Heart Valve Dis | 2011 |
Valvular heart disease with the use of fenfluramine-phentermine.
Topics: Anti-Obesity Agents; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramine; Gast | 2011 |
Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
Topics: Adult; Aged; Appetite Depressants; Cohort Studies; Databases, Factual; Female; Fenfluramine; France; | 2012 |
Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy.
Topics: Adult; Aortic Valve; Bioprosthesis; Cicatrix, Hypertrophic; Female; Fenfluramine; Fibrosis; Heart Va | 2012 |
Appetite suppressant was probably responsible for 1300 deaths, study shows.
Topics: Appetite Depressants; Drug Industry; Drug-Related Side Effects and Adverse Reactions; Fenfluramine; | 2012 |
Re: Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
Topics: Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Hospitalization; Humans; Male | 2012 |
European legislators tighten rules on drug safety.
Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Diabetes Mellitus, Type 2; Europe; Fe | 2012 |
Benfluorex-induced cardiac valve injury.
Topics: Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Hospitalization; Humans; Male | 2012 |
Fen-Phen-noumenon: A mass tort litigation and settlement about to come and go.
Topics: Appetite Depressants; Central Nervous System Stimulants; Fenfluramine; Heart Valve Diseases; Humans; | 2002 |
Morphology of anorexigen-associated valve disease by transthoracic and transesophageal echocardiography.
Topics: Adult; Aortic Valve; Appetite Depressants; Body Mass Index; Dexfenfluramine; Drug Combinations; Echo | 2002 |
[Valvular heart disease associated with benfluorex].
Topics: Appetite Depressants; Female; Fenfluramine; Fibrosis; Heart Valve Diseases; Heart Valve Prosthesis I | 2003 |
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Cell Division; Cells, Cultured; COS Cells; Fenfluramine; Hea | 2003 |
Do these doctors give medicine a black eye?
Topics: Appetite Depressants; Compensation and Redress; Drug Industry; Electrocardiography; Expert Testimony | 2003 |
Taking things to heart.
Topics: Appetite Depressants; Dexfenfluramine; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans | 2004 |
Comparison of combinations of drugs for treatment of obesity: body weight and echocardiographic status.
Topics: Adult; Appetite Depressants; Body Mass Index; Drug Therapy, Combination; Fenfluramine; Fluoxetine; H | 2007 |
Valvular heart disease associated with fenfluramine detected 7 years after discontinuation of treatment.
Topics: Adult; Aortic Valve; Biopsy, Needle; Dose-Response Relationship, Drug; Drug Administration Schedule; | 2007 |
From the Food and Drug Administration.
Topics: Appetite Depressants; Diabetes Mellitus; Emergency Medical Services; Fenfluramine; Heart Valve Disea | 1997 |
Report links appetite suppressants with heart disease. FDA encourages reporting of like events.
Topics: Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Obesity | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Drug Combinations; Female; Fenfluramine; He | 1997 |
Diet pills redux.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte | 1997 |
Further cases of valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; | 1997 |
Valvular heart disease associated with dexfenfluramine.
Topics: Adult; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans; Mitral Valve Insuff | 1997 |
A dangerous duo? A combination of common diet drugs (fen-phen) may lead to heart valve disease.
Topics: Appetite Depressants; Drug Combinations; Drug Synergism; Female; Fenfluramine; Heart Valve Diseases; | 1997 |
Fen-phen and risk of valvular disease.
Topics: Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Phenter | 1997 |
Thalidomide checks might have saved Redux.
Topics: Appetite Depressants; Drug Approval; Fenfluramine; Heart Valve Diseases; HIV Wasting Syndrome; Patie | 1997 |
Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: U.S. Department of Health and Human Services interim public health recommendations, November 1997.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Appetite Depressants; Echocardiography; Female | 1997 |
From the Centers for Disease Control and Prevention. Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: US Department of Health and Human Services interim public health recommendations, November 1997.
Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Echocardiography; Fenfluramine; Heart | 1997 |
Prepublication release of Journal articles.
Topics: Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Publishing | 1997 |
US journal finds lower risk from diet pills.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Ultrasonography | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Appetite Depressants; Diethylpropion; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Appetite Depressants; Diabetes Mellitus, Type 2; Drug Combinations; Female; Fenfluramine; Heart Valv | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Animals; Appetite Depressants; Drug Evaluation, Preclinical; Fenfluramine; Heart Valve Diseases; Hum | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Appetite Depressants; Bias; Drug and Narcotic Control; Drug Combinations; Female; Fenfluramine; Hear | 1997 |
Asymptomatic mitral and aortic valve disease is seen in half of the patients taking 'phen-fen'.
Topics: Aortic Valve; Appetite Depressants; Echocardiography, Doppler, Color; Fenfluramine; Heart Valve Dise | 1998 |
The treatment of obesity with drugs.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte | 1998 |
[Drug-clinics. The hue and cry over central appetite suppressants!].
Topics: Adrenergic Agents; Adult; Amphetamines; Appetite; Appetite Depressants; Female; Fenfluramine; Heart | 1997 |
Serotonin: it's possible to have too much of a good thing.
Topics: Bulimia; Depressive Disorder; Fenfluramine; Heart Valve Diseases; Humans; Obsessive-Compulsive Disor | 1997 |
Mitral valve disease associated with use of anorexigenic medications.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte | 1998 |
Anorectic drugs and valvular heart disease: a biological and clinical perspective.
Topics: Adult; Appetite Depressants; Echocardiography; Female; Fenfluramine; Heart Valve Diseases; Humans; M | 1998 |
Valve disease and diet pills--where do we stand?
Topics: Adult; Aged; Aged, 80 and over; Appetite Depressants; Dopamine Agents; Drug Therapy, Combination; Ec | 1998 |
Guidelines for users of diet pills.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine | 1998 |
Phen-fen fallout. Financial side effects.
Topics: Appetite Depressants; Echocardiography; Fenfluramine; Health Maintenance Organizations; Heart Valve | 1998 |
Fen-phen's message to dentists.
Topics: Appetite Depressants; Dental Care for Chronically Ill; Drug Combinations; Fenfluramine; Heart Valve | 1998 |
Anorectic drugs and valvular heart disease.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Serotonin | 1998 |
Anorectic drugs and valvular heart disease.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans | 1998 |
Valve disease associated with chronic intake of fenfluramines.
Topics: Adult; Aortic Valve; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans; Middl | 1998 |
The "phen-pro" diet drug combination is not associated with valvular heart disease.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Mitral Valve; Phentermine | 1998 |
Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998.
Topics: Aged; Anti-Arrhythmia Agents; Anticholesteremic Agents; Appetite Depressants; Clinical Trials as Top | 1998 |
The fen-phen finale: a study of weight loss and valvular heart disease.
Topics: Adult; Affect; Appetite; Behavior Therapy; Drug Therapy, Combination; Echocardiography, Doppler; Fem | 1998 |
Anesthesia risks in patients who have had antiobesity medication.
Topics: Anesthesia, General; Appetite Depressants; Contraindications; Fenfluramine; Heart Valve Diseases; Hu | 1998 |
Appetite suppressants and valvular heart disease.
Topics: Appetite Depressants; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phente | 1998 |
Regression of multivalvular regurgitation after the cessation of fenfluramine and phentermine treatment.
Topics: Adult; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; | 1998 |
Risks of heart-valve abnormalities with appetite suppressants.
Topics: Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Risk Fact | 1998 |
[Pulmonary hypertension and heart valve diseases induced by fenfluramine? Hypothesis or certitude? Myth or reality?].
Topics: Animals; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; He | 1998 |
Former Fen-Phen users may need prophylactic antibiotic before treatment.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Drug Combinations; En | 1998 |
Risk for valvular heart disease among users of fenfluramine and dexfenfluramine who underwent echocardiography before use of medication.
Topics: Adult; Appetite Depressants; Cohort Studies; Dexfenfluramine; Disease Progression; Echocardiography; | 1998 |
Diet-drug debacle.
Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Obesity; United S | 1998 |
Studies confirm link between fen-phen and heart-valve disease.
Topics: Appetite Depressants; Cyclobutanes; Dexfenfluramine; Drug Combinations; Fenfluramine; Heart Valve Di | 1998 |
Appetite-suppressant drugs and valvular heart disease.
Topics: Appetite Depressants; Data Interpretation, Statistical; Dexfenfluramine; Fenfluramine; Heart Valve D | 1999 |
Appetite-suppressant drugs and valvular heart disease.
Topics: Appetite Depressants; Bias; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Od | 1999 |
After fen-phen.
Topics: Antidepressive Agents, Second-Generation; Appetite Depressants; Consumer Product Safety; Fenfluramin | 1997 |
Severe heart valve disease on appetite suppressants.
Topics: Adult; Appetite Depressants; Case-Control Studies; Diethylpropion; Drug Approval; Drug Combinations; | 1998 |
Dose effect of fenfluramine-phentermine in the production of valvular heart disease.
Topics: Appetite Depressants; Diseases in Twins; Dose-Response Relationship, Drug; Drug Therapy, Combination | 1999 |
Valvular heart disease in fenfluramine- phentermine-treated patients: a comparison with control patients.
Topics: Appetite Depressants; Body Mass Index; Diet, Reducing; Drug Combinations; Echocardiography; Female; | 1999 |
Anorectic therapy and valvular heart disease: a reappraisal.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Obesity; Phentermine | 1999 |
Dose-effect of fenfluramine use on the severity of valvular heart disease among fen-phen patients with valvulopathy.
Topics: Adult; Aortic Valve; Appetite Depressants; Dose-Response Relationship, Drug; Drug Combinations; Fema | 1999 |
Detailed examination of fenfluramine-phentermine users with valve abnormalities identified in Fargo, North Dakota.
Topics: Adult; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Middl | 1999 |
Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters.
Topics: Adult; Appetite Depressants; Depression; Eating; Feeding and Eating Disorders; Female; Fenfluramine; | 1999 |
Low prevalence of valvular heart disease in 226 phentermine-fenfluramine protocol subjects prospectively followed for up to 30 months.
Topics: Adult; Appetite Depressants; Echocardiography, Transesophageal; Female; Fenfluramine; Follow-Up Stud | 1999 |
Fen/phen and valvular heart disease: if it sounds too bad to be true, perhaps it isn't.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Appetite Depressants; Echocardiography, Transesophag | 1999 |
[Appetite suppressants and heart valve disorders].
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine | 1999 |
Prevention of infective endocarditis associated with dental treatment and other medical interventions. National Heart Foundation.
Topics: Adult; Anti-Obesity Agents; Antibiotic Prophylaxis; Aortic Valve Insufficiency; Cefuroxime; Cephalos | 1999 |
[Fenfluramines and cardiac valvular lesions].
Topics: Adult; Aged; Dexfenfluramine; Echocardiography, Doppler; Electrocardiography, Ambulatory; Female; Fe | 1999 |
The fen-phen controversy: is regression another piece of the puzzle?
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine | 1999 |
Diet drug maker agrees to $3.75 billion settlement.
Topics: Dexfenfluramine; Drug Industry; Fenfluramine; Heart Valve Diseases; Humans; United States | 1999 |
Aminorex to Fen/Phen: an epidemic foretold.
Topics: Aminorex; Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Human | 1999 |
Aminorex to Fen/Phen: an epidemic foretold.
Topics: Aminorex; Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Human | 1999 |
Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
Topics: Animals; Appetite Depressants; Cell Line; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; | 2000 |
The need for greater involvement of regulatory agencies in assessing adverse drug reactions.
Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Drug Industry; Fenfluramine; Governme | 2000 |
Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Dexfenfluramine; Echocardiography | 2000 |
Heart valve disorders and appetite-suppressant drugs.
Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Sero | 2000 |
Anorectic-induced valvulopathy.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine; Time Factors | 2000 |
Was the danger of diet pills overstated?
Topics: Appetite Depressants; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phente | 2000 |
Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans | 2000 |
Fen-phen manufacturers, not physicians, are liable.
Topics: Appetite Depressants; Drug Combinations; Drug Industry; Fenfluramine; Heart Valve Diseases; Humans; | 2000 |
More on heart disease and diet pills.
Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Serotonin Agents | 2000 |
[Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants].
Topics: Aged; Appetite Depressants; Drug Therapy, Combination; Female; Fenfluramine; Heart Valve Diseases; H | 1998 |
Cardiac valvulopathy.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care; Dexfenfluramine; Fenfluramine; Heart Valv | 2000 |
Lessons from the fenfluramines: antiobesity medications are frequently misused.
Topics: Anti-Obesity Agents; Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Substance-Rel | 2000 |
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.
Topics: Dose-Response Relationship, Drug; Ergotamine; Fenfluramine; Heart Valve Diseases; Humans; Methylergo | 2000 |
Diet drugs and cardiac valvulopathy: a survey of dental patients.
Topics: Adult; Antibiotic Prophylaxis; Appetite Depressants; Dental Care; Dexfenfluramine; Endocarditis, Bac | 2000 |
By the way, doctor...I used a diet pill--fenfluramine--a few years ago, but stopped as soon as I heard about it causing heart-valve problems. My doctor has been doing echocardiograms on me every six months. So far, everything looks good. How long do you t
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Time Factors; Ultrasonography | 2001 |
Valve disease due to appetite suppressants (cont'd).
Topics: Aortic Valve; Appetite Depressants; Clinical Trials as Topic; Dexfenfluramine; Fenfluramine; Heart V | 1999 |
Operation for anorexigen-associated valvular heart disease.
Topics: Adult; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Mi | 2001 |
Reversal of Phen-Fen associated valvular regurgitation documented by serial echocardiography.
Topics: Appetite Depressants; Echocardiography; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle A | 2002 |