Page last updated: 2024-10-27

fenfluramine and Heart Valve Diseases

fenfluramine has been researched along with Heart Valve Diseases in 155 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).

Research Excerpts

ExcerptRelevanceReference
" This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylpropion, mazindol, and phentermine), as well as over-the-counter adrenergic drugs (phenylpropanolamine and ephedrine); recent clinical studies documenting the safety and efficacy of a new medication for obesity treatment, sibutramine, recently approved by the Food and Drug Administration for long-term use; and recent studies characterizing the valvulopathy associated with fenfluramine and dexfenfluramine, serotonergic medications for obesity which have been removed from the markets."8.80Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity. ( Ryan, DH, 2000)
"The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman."7.78Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012)
"Benfluorex is a fenfluramine derivative which has been marketed between 1976 and 2009."5.46Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report. ( Banfi, C; Baufreton, C; Bruneval, P; Ennezat, PV; Fouquet, O; Giraud, R; Rousselet, MC, 2017)
"Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2."5.36Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010)
"To determine the echocardiographic changes over time of valvular heart lesions in patients who took the weight loss drugs fenfluramine and phentermine."5.09Echocardiographic improvement over time after cessation of use of fenfluramine and phentermine. ( Bailey, KR; Connolly, HM; Grogan, M; Hensrud, DD; Jensen, MD; Miller, FA, 1999)
"From the group of 720 smokers who had originally participated in the smoking cessation therapy trial, 619 women were enrolled; data from 530 (276 in the fenfluramine group and 254 in the placebo group) were evaluable."5.09Echocardiographic examination of women previously treated with fenfluramine: long-term follow-up of a randomized, double-blind, placebo-controlled trial. ( Balady, GJ; Bowen, DJ; Constantine, G; Davidoff, R; Davis, KD; McTiernan, A; Mendes, LA; Rudolph, RE, 2001)
" This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylpropion, mazindol, and phentermine), as well as over-the-counter adrenergic drugs (phenylpropanolamine and ephedrine); recent clinical studies documenting the safety and efficacy of a new medication for obesity treatment, sibutramine, recently approved by the Food and Drug Administration for long-term use; and recent studies characterizing the valvulopathy associated with fenfluramine and dexfenfluramine, serotonergic medications for obesity which have been removed from the markets."4.80Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity. ( Ryan, DH, 2000)
"The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman."3.78Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012)
" As a derivative of fenfluramine with an appetite suppressant action, benfluorex is preferentially used in overweight patients."3.75Fenfluramine-like cardiovascular side-effects of benfluorex. ( Boutet, K; Carlhant-Kowalski, D; Frachon, I; Gut-Gobert, C; Humbert, M; Jobic, Y; Leroyer, C; Simonneau, G; Sitbon, O, 2009)
"To assess weight loss, as well as the prevalence of valvular heart disease, in 21 obese women who completed 2 years of treatment by fenfluramine and phentermine (fen-phen) in June 1997."3.70The fen-phen finale: a study of weight loss and valvular heart disease. ( Aber, JL; Berkowitz, RI; Foster, GD; Silvestry, F; St John Sutton, MG; Stunkard, AJ; Vogt, RA; Wadden, TA, 1998)
"22 severe binge eaters, 17 moderate binge eaters, and 16 non-binge eaters received phentermine resin 15mg/day and dl-fenfluramine 20mg three times daily over a 6 month period for weight loss."3.70Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters. ( Alger, SA; Cerulli, J; Fein, S; Howard, L; Malone, M, 1999)
"Serotoninergic appetite-suppressant drugs, fenfluramine and dexfenfluramine, were withdrawn from the market in September 1997 on account of two major cardiopulmonary complications: primary pulmonary hypertension and valvular regurgitation."3.70[Appetite suppressants and heart valve disorders]. ( Adams, C; Cohen, A, 1999)
"To evaluate cardiovascular status and the prevalence of valvular abnormalities, as assessed by clinical cardiovascular parameters and echocardiography, in patients treated for obesity with dexfenfluramine or phentermine/fenfluramine."3.70Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine. ( Constantine, G; Davis, KD; Gardin, JM; Leung, C; Reid, CL; Schumacher, D, 2000)
"Fenfluramine, which was previously approved as a weight loss drug, was withdrawn in 1997 when reports of cardiac valvulopathy emerged."2.94Cardiovascular safety of fenfluramine in the treatment of Dravet syndrome: Analysis of an ongoing long-term open-label safety extension study. ( Agarwal, A; Farfel, G; Galer, BS; Keane, MG; Lai, WW; Pringsheim, M; Wong, PC, 2020)
"Aortic regurgitation was detected in 18 subjects, mitral regurgitation in 3 subjects, and both aortic and mitral regurgitation in 1 subject; no one had severe regurgitation."2.70Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs. ( Blackburn, GL; Burger, AJ; Charlamb, MJ; Notarianni, M; Sherman, HB; Singh, S, 2001)
" Further studies should be conducted to determine the subsequent course of benfluorex-induced VHD and PAH, and to identify genetic, biological and clinical factors that determine individual susceptibility to developing such adverse effects."2.50Adverse effects of benfluorex on heart valves and pulmonary circulation. ( Andréjak, M; Maréchaux, S; Peltier, M; Szymanski, C; Tribouilloy, C, 2014)
" Receptorome screening has implicated N-deethylation of fenfluramine and serotonin 5-hydroxy-t-ryptamine 2B receptors in the adverse effects of the drug; subsequent studies corroborated this finding."2.43Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'. ( Roth, BL; Setola, V, 2005)
"Obesity is a chronic disorder that is associated with significant co-morbidity and early mortality."2.42Anorexigen-induced cardiac valvulopathy and female gender. ( Gross, SB; Naqvi, TZ, 2003)
"Patients with Dravet syndrome who completed one of three phase 3 clinical trials of fenfluramine could enroll in the open-label extension (OLE) study (NCT02823145)."1.72Long-term cardiovascular safety of fenfluramine in patients with Dravet syndrome treated for up to 3 years: Findings from serial echocardiographic assessments. ( Agarwal, A; Farfel, GM; Galer, BS; Gammaitoni, AR; Pinto, FJ; Wong, PC, 2022)
"Benfluorex is a fenfluramine derivative which has been marketed between 1976 and 2009."1.46Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report. ( Banfi, C; Baufreton, C; Bruneval, P; Ennezat, PV; Fouquet, O; Giraud, R; Rousselet, MC, 2017)
"Fenfluramine has been associated with an increased risk of pulmonary hypertension and valvular disease."1.37Mitral and aortic valvular disease associated with benfluorex use. ( Castellant, P; Etienne, Y; Fatemi, M; Frachon, I; Jobic, Y; Quintin-Roué, I, 2011)
"Benfluorex has the same adverse effects as those that led to the withdrawal of amphetamine appetite suppressants such as fenfluramine."1.36Benfluorex: increasing reports of valve disorders. ( , 2010)
"Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2."1.36Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010)
"Pulmonary hypertension was strongly associated with MR but not AR."1.35Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals. ( Allen, MR; Dahl, CF; Hopkins, PN; Urie, PM, 2008)
"Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant until it was reported to be associated with valvular heart disease."1.31Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine. ( Abbaszade, I; Brown, BS; Burn, TC; Corjay, MH; Fitzgerald, LW; Hartig, PR; Hollis, GF; Hollis, JM; Largent, BL; Link, JR; Meunier, PC; Patterson, JP; Robertson, DW; Robichaud, AJ; Sun, JH; Valentine, PA, 2000)
"The most common finding was mild aortic regurgitation."1.31Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience. ( Connolly, HM; Grogan, M; Miller, FA; Teramae, CY, 2000)
"To determine whether the severity of valvulopathy was associated with the dosage of fenfluramine taken by fenfluramine-phentermine users with valvulopathy."1.30Dose-effect of fenfluramine use on the severity of valvular heart disease among fen-phen patients with valvulopathy. ( Bowman, BA; Graham, DJ; Green, L; Li, R; Serdula, MK; Williamson, DF, 1999)
"If mild or greater aortic or mitral regurgitation is present, antibiotic prophylaxis against endocarditis is recommended."1.30Prevention of infective endocarditis associated with dental treatment and other medical interventions. National Heart Foundation. ( Ellis-Pegler, RB; Hay, KD; Lang, SD; Neutze, JM; Swinburn, BA, 1999)
"Marked obesity is an independent risk factor for multi-system morbidity."1.30[Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants]. ( Goldstein, SE; Levy, Y; Shoenfeld, Y, 1998)

Research

Studies (155)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's69 (44.52)18.2507
2000's47 (30.32)29.6817
2010's36 (23.23)24.3611
2020's3 (1.94)2.80

Authors

AuthorsStudies
Agarwal, A2
Farfel, GM1
Gammaitoni, AR1
Wong, PC2
Pinto, FJ1
Galer, BS2
Bender, AM1
Parr, LC1
Livingston, WB1
Lindsley, CW1
Merryman, WD1
Lai, WW1
Farfel, G1
Pringsheim, M2
Keane, MG3
Schoonjans, AS1
Marchau, F1
Paelinck, BP1
Lagae, L1
Gammaitoni, A1
Ceulemans, B1
Goldberg, E1
Grau, JB1
Fortier, JH1
Salvati, E1
Levy, RJ2
Ferrari, G1
Dyer, O1
Rajamannan, NM1
Szymanski, C2
Andréjak, M1
Peltier, M1
Maréchaux, S3
Tribouilloy, C3
Rusinaru, D1
Jobic, Y7
Ederhy, S1
Donal, E1
Réant, P1
Arnalsteen, E1
Boulanger, J1
Garban, T1
Ennezat, PV3
Jeu, A1
Plurien, F1
Bruneval, P2
Iung, B1
Le Ven, F2
Alavi, Z1
Etienne, Y4
Didier, R1
Porcher, R1
Baufreton, C1
Rousselet, MC1
Fouquet, O1
Giraud, R1
Banfi, C1
Dahl, CF1
Allen, MR1
Urie, PM1
Hopkins, PN1
Boutet, K1
Frachon, I3
Gut-Gobert, C1
Leroyer, C2
Carlhant-Kowalski, D1
Sitbon, O1
Simonneau, G1
Humbert, M2
Droogmans, S2
Kerkhove, D1
Cosyns, B2
Van Camp, G2
Rothman, RB4
Baumann, MH2
Connolly, JM1
Bakay, MA1
Fulmer, JT1
Gorman, RC1
Gorman, JH1
Oyama, MA1
Bhattacharyya, S1
Schapira, AH1
Mikhailidis, DP1
Davar, J1
Le Gal, G1
Gueffet, JP2
Piriou, N1
Trochu, JN1
Weill, A1
Païta, M1
Tuppin, P1
Fagot, JP1
Neumann, A1
Simon, D1
Ricordeau, P1
Montastruc, JL1
Allemand, H1
Hajjo, R1
Grulke, CM1
Golbraikh, A1
Setola, V3
Huang, XP1
Roth, BL4
Tropsha, A1
Habib, G2
Eicher, JC1
Blanchard-Lemoine, B1
Rousseau, J1
Hénon, P1
Mullard, A1
Nau, JY2
Fatemi, M1
Castellant, P1
Quintin-Roué, I1
Boudes, A1
Lavoute, C1
Avierinos, JF1
Le Dolley, Y1
Villacampa, C1
Salem, A1
Loundou, AD1
Michel, N1
Renard, S1
Surapaneni, P1
Vinales, KL1
Najib, MQ1
Chaliki, HP1
Fournier, A1
Zureik, M1
Ayme-Dietrich, E1
Lawson, R1
Gasser, B1
Dallemand, R1
Bischoff, N1
Monassier, L1
Benkimoun, P1
Deltour, N1
Coste, M1
Tupinon-Mathieu, I1
Derumeaux, G1
Ernande, L1
Serusclat, A1
Servan, E1
Bruckert, E1
Rousset, H1
Senn, S1
Van Gaal, L1
Picandet, B1
Gavini, F1
Moulin, P1
Watson, R1
Acar, J1
Vaughan, SF1
Loke, YK1
Derry, S1
Pritchard-Copley, A1
Seghatol, FF1
Rigolin, VH1
Roldan, CA1
Gelgand, EA1
Decker, P1
Prasad, A1
Shively, BK1
Gross, SB3
Lepor, NE1
Sachdev, M1
Miller, WC1
Ryan, T1
Jollis, JG1
Rafel Ribera, J1
Casañas Muñoz, R1
Anguera Ferrando, N1
Batalla Sahún, N1
Castro Cels, A1
Pujadas Capmany, R1
Naqvi, TZ1
Hufeisen, SJ2
Grande-Allen, KJ1
Vesely, I1
Glennon, RA1
Blough, B1
Rice, B1
Hess, MA1
Schachter, M1
Smith, DA1
Schmid, EF1
Whigham, LD1
Dhurandhar, NV1
Rahko, PS1
Atkinson, RL1
Greffe, G1
Chalabreysse, L1
Mouly-Bertin, C1
Lantelme, P1
Thivolet, F1
Aulagner, G1
Obadia, JF1
Donnelly, KB1
Nightingale, SL1
Connolly, HM5
Crary, JL2
McGoon, MD2
Hensrud, DD2
Edwards, BS1
Edwards, WD1
Schaff, HV2
Curfman, GD1
Graham, DJ2
Green, L2
Cannistra, LB2
Davis, SM1
Bauman, AG1
Boughner, DR1
SoRelle, R2
Brower, V1
Kassirer, JP1
Angell, M1
Josefson, D1
Thompson, PD1
Kurz, X1
Van Ermen, A1
Redmon, B1
Raatz, S1
Bantle, JP2
Wolff, FW1
Spitzer, WO1
Griffen, L2
Anchors, M2
Hirsch, J1
Scheen, AJ1
Stahl, SM1
Cheng, TO3
Wong, J1
Reddy, SS1
Klein, AL1
Aurigemma, GP1
Gaasch, WH1
Sandrick, KM1
Hilsen, K1
Davis, S1
Iyer, P1
Krynicki, PF1
Malak, J1
Deprez, P1
Adam, JF1
Alexander, JH1
Greenbaum, AB1
Hudson, MP1
Kong, DF1
Miller, JM1
Tung, CY1
Whellan, DJ1
Wadden, TA2
Berkowitz, RI2
Silvestry, F1
Vogt, RA1
St John Sutton, MG1
Stunkard, AJ1
Foster, GD2
Aber, JL2
Shiffman, MA1
Devereux, RB1
Cannistra, AJ1
Baird, IM1
Godeau, P1
Cherin, P1
Tellier, P3
Biron, CR1
Wee, CC1
Phillips, RS1
Aurigemma, G1
Erban, S1
Kriegel, G1
Riley, M1
Douglas, PS1
Parisi, AF1
Williamson, DF2
Yanovski, SZ1
Shapiro, S1
Cowley, G1
Springen, K1
Tovar, EA1
Landa, DW1
Borsari, BE1
Silvestry, FE2
Sutton, MG1
St John Sutton, M1
Li, R1
Serdula, MK1
Bowman, BA1
Kimmel, SE1
Jones, J1
Kinman, JL1
Beare, J1
Sammel, M1
Sutton, MS1
Strom, BL1
Alger, SA1
Malone, M1
Cerulli, J1
Fein, S1
Howard, L1
Burger, AJ2
Sherman, HB2
Charlamb, MJ2
Kim, J1
Asinas, LA1
Flickner, SR1
Blackburn, GL2
Schiller, NB1
Pallasch, TJ1
Adams, C1
Cohen, A1
Ellis-Pegler, RB1
Hay, KD1
Lang, SD1
Neutze, JM1
Swinburn, BA1
Ewalenko, M1
Richard, C1
Vandenbossche, JL1
Grogan, M2
Miller, FA2
Bailey, KR1
Jensen, MD1
Asinger, RW1
Pollick, C1
Fitzgerald, LW1
Burn, TC1
Brown, BS1
Patterson, JP1
Corjay, MH1
Valentine, PA1
Sun, JH1
Link, JR1
Abbaszade, I1
Hollis, JM1
Largent, BL1
Hartig, PR1
Hollis, GF1
Meunier, PC1
Robichaud, AJ1
Robertson, DW1
Sniderman, AD1
Poston, WS1
Foreyt, JP1
Gardin, JM1
Schumacher, D1
Constantine, G2
Davis, KD2
Leung, C1
Reid, CL1
Jick, H1
Redmon, JB1
Raatz, SK1
Kwong, CA1
Swanson, JE1
Teramae, CY1
Allen, S1
Henderson, J1
Goldstein, SE1
Levy, Y1
Shoenfeld, Y1
Wolf, I1
Mouallem, M1
Farfel, Z1
Alexander, RE1
Lawless-Liday, C1
Force, RW1
Savage, JE1
Rauser, L1
McBride, A1
Ryan, DH1
Weissman, NJ1
Rudin, R1
Carpenter, W1
Davidoff, R1
McTiernan, A1
Balady, GJ1
Mendes, LA1
Rudolph, RE1
Bowen, DJ1
Lee, TH1
Singh, S1
Notarianni, M1
Caccitolo, JA1
Rubenson, DS1
Orszulak, TA1
Vagelos, R1
Jacobs, M1
Popp, RL1
Liang, D1

Reviews

24 reviews available for fenfluramine and Heart Valve Diseases

ArticleYear
2B Determined: The Future of the Serotonin Receptor 2B in Drug Discovery.
    Journal of medicinal chemistry, 2023, 08-24, Volume: 66, Issue:16

    Topics: Drug Discovery; Fenfluramine; Heart Valve Diseases; Humans; Receptor, Serotonin, 5-HT2B; Serotonin

2023
Cardiovascular safety of low-dose fenfluramine in Dravet syndrome: a review of its benefit-risk profile in a new patient population.
    Current medical research and opinion, 2017, Volume: 33, Issue:10

    Topics: Adult; Appetite Depressants; Dexfenfluramine; Epilepsies, Myoclonic; Fenfluramine; Heart Valve Disea

2017
Drug-related cardiac valve disease.
    Prescrire international, 2013, Volume: 22, Issue:144

    Topics: Ergot Alkaloids; Fenfluramine; Heart Valve Diseases; Humans; Hypercalcemia; Hyperphosphatemia; Inter

2013
Adverse effects of benfluorex on heart valves and pulmonary circulation.
    Pharmacoepidemiology and drug safety, 2014, Volume: 23, Issue:7

    Topics: Echocardiography; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Hypertension, Pulmonary;

2014
Role of echocardiography in toxic heart valvulopathy.
    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2009, Volume: 10, Issue:4

    Topics: Animals; Drug-Related Side Effects and Adverse Reactions; Echocardiography, Doppler, Color; Female;

2009
Serotonergic drugs and valvular heart disease.
    Expert opinion on drug safety, 2009, Volume: 8, Issue:3

    Topics: Animals; Fenfluramine; Heart Valve Diseases; Humans; Receptor, Serotonin, 5-HT2B; Serotonin; Seroton

2009
Drug-induced fibrotic valvular heart disease.
    Lancet (London, England), 2009, Aug-15, Volume: 374, Issue:9689

    Topics: Antiparkinson Agents; Appetite Depressants; Cabergoline; Dexfenfluramine; Dopamine Agonists; Drug Mo

2009
Appetite suppressants and valvular heart disease - a systematic review.
    BMC clinical pharmacology, 2002, Aug-23, Volume: 2

    Topics: Appetite Depressants; Clinical Trials as Topic; Cohort Studies; Dexfenfluramine; Fenfluramine; Heart

2002
Appetite suppressants and valvular heart disease.
    Current opinion in cardiology, 2002, Volume: 17, Issue:5

    Topics: Appetite Depressants; Carcinoid Heart Disease; Dexfenfluramine; Fenfluramine; Heart Valve Diseases;

2002
Anorexigen-related cardiopulmonary toxicity.
    Reviews in cardiovascular medicine, 2000,Fall, Volume: 1, Issue:2

    Topics: Aminorex; Appetite Depressants; Dexfenfluramine; Echocardiography; Fenfluramine; Heart Valve Disease

2000
Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies.
    American heart journal, 2002, Volume: 144, Issue:6

    Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Disease

2002
Anorexigen-induced cardiac valvulopathy and female gender.
    Current women's health reports, 2003, Volume: 3, Issue:2

    Topics: Adult; Appetite Depressants; Dexfenfluramine; Echocardiography; Female; Fenfluramine; Heart Valve Di

2003
Cardiac valvulopathy.
    Hospital medicine (London, England : 1998), 2005, Volume: 66, Issue:4

    Topics: Antiparkinson Agents; Echocardiography, Doppler, Color; Ergotamine; Fenfluramine; Heart Valve Diseas

2005
Drug withdrawals and the lessons within.
    Current opinion in drug discovery & development, 2006, Volume: 9, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbolines; Colitis, Ischemic; Drug Design; Drug-R

2006
Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.
    Expert opinion on drug metabolism & toxicology, 2005, Volume: 1, Issue:3

    Topics: Animals; Appetite Depressants; Cardiovascular Diseases; Drug Evaluation, Preclinical; Drug-Related S

2005
Cardiac valvular pathology: comparative pathology and animal models of acquired cardiac valvular diseases.
    Toxicologic pathology, 2008, Volume: 36, Issue:2

    Topics: Animals; Appetite Depressants; Disease Models, Animal; Dogs; Fenfluramine; Heart Valve Diseases; Hea

2008
Current status of fenfluramine/dexfenfluramine-induced cardiac valvulopathy.
    Journal of the California Dental Association, 1999, Volume: 27, Issue:5

    Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Dexfenfluramine; Drug

1999
Obesity drugs and the heart.
    Current problems in cardiology, 1999, Volume: 24, Issue:12

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermi

1999
Scientific and legal issues in fenfluramine/dexfenfluramine litigation.
    Texas medicine, 2000, Volume: 96, Issue:2

    Topics: Anti-Obesity Agents; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulm

2000
Appetite suppressants and cardiac valvulopathy. Current clinical perspectives.
    Advance for nurse practitioners, 1999, Volume: 7, Issue:10

    Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pul

1999
[Valvular heart disease and primary pulmonary hypertension associated with fenfluramine-phentermine].
    Harefuah, 1998, Dec-01, Volume: 135, Issue:11

    Topics: Appetite Depressants; Cardiomyopathies; Drug Therapy, Combination; Fenfluramine; Heart Valve Disease

1998
Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity.
    Endocrine, 2000, Volume: 13, Issue:2

    Topics: Adrenergic Agents; Appetite Depressants; Cyclobutanes; Dexfenfluramine; Dextroamphetamine; Fenfluram

2000
Appetite suppressants and valvular heart disease.
    The American journal of the medical sciences, 2001, Volume: 321, Issue:4

    Topics: Age Factors; Appetite Depressants; Dexfenfluramine; Drug Therapy, Combination; Fenfluramine; Heart V

2001
Fenfluramines, idiopathic pulmonary primary hypertension and cardiac valve disorders: facts and artifacts.
    Annales de medecine interne, 2001, Volume: 152, Issue:7

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Obesity;

2001

Trials

6 trials available for fenfluramine and Heart Valve Diseases

ArticleYear
Cardiovascular safety of fenfluramine in the treatment of Dravet syndrome: Analysis of an ongoing long-term open-label safety extension study.
    Epilepsia, 2020, Volume: 61, Issue:11

    Topics: Adolescent; Child; Child, Preschool; Double-Blind Method; Electrocardiography; Epilepsies, Myoclonic

2020
Echocardiographic evidence for valvular toxicity of benfluorex: a double-blind randomised trial in patients with type 2 diabetes mellitus.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Aged; Diabetes Mellitus, Type 2; Echocardiography; Female; Fenfluramine; Glycated Hemoglobin; Heart

2012
Echocardiographic improvement over time after cessation of use of fenfluramine and phentermine.
    Mayo Clinic proceedings, 1999, Volume: 74, Issue:12

    Topics: Adrenergic Agents; Adult; Appetite Depressants; Body Mass Index; Double-Blind Method; Echocardiograp

1999
Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin.
    The American journal of cardiology, 2000, Apr-01, Volume: 85, Issue:7

    Topics: Administration, Oral; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fem

2000
Echocardiographic examination of women previously treated with fenfluramine: long-term follow-up of a randomized, double-blind, placebo-controlled trial.
    Archives of internal medicine, 2001, Jun-11, Volume: 161, Issue:11

    Topics: Adolescent; Adult; Aged; Body Mass Index; Double-Blind Method; Echocardiography; Female; Fenfluramin

2001
Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs.
    International journal of cardiology, 2001, Volume: 79, Issue:2-3

    Topics: Aortic Valve Insufficiency; Appetite Depressants; Boston; Drug Therapy, Combination; Female; Fenflur

2001

Other Studies

125 other studies available for fenfluramine and Heart Valve Diseases

ArticleYear
Long-term cardiovascular safety of fenfluramine in patients with Dravet syndrome treated for up to 3 years: Findings from serial echocardiographic assessments.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2022, Volume: 39

    Topics: Adolescent; Child; Child, Preschool; Echocardiography; Epilepsies, Myoclonic; Epileptic Syndromes; F

2022
Serotonin and catecholamines in the development and progression of heart valve diseases.
    Cardiovascular research, 2017, Jul-01, Volume: 113, Issue:8

    Topics: Animals; Catecholamines; Disease Progression; Fenfluramine; Heart Valve Diseases; Humans; Neurotrans

2017
France to prosecute its drug regulator and Servier in scandal over diabetes drug.
    BMJ (Clinical research ed.), 2017, 09-11, Volume: 358

    Topics: Drug and Narcotic Control; Drug Industry; Fenfluramine; France; Fraud; Heart Valve Diseases; Homicid

2017
Fenfluramine-Phentermine is Associated with an Increase in Cellular Proliferation Ex Vivo and In Vitro.
    The Journal of heart valve disease, 2017, Volume: 26, Issue:4

    Topics: Animals; Anti-Obesity Agents; Aortic Valve; Cardiotoxicity; Case-Control Studies; Cell Proliferation

2017
Benfluorex and cardiac valve disease: long delay in publication.
    Prescrire international, 2013, Volume: 22, Issue:135

    Topics: Access to Information; Appetite Depressants; Fenfluramine; Heart Valve Diseases; Heart Valves; Human

2013
Exposure to benfluorex: left heart valve disease very common.
    Prescrire international, 2013, Volume: 22, Issue:140

    Topics: Echocardiography; Fenfluramine; France; Heart Valve Diseases; Humans; Hypolipidemic Agents; Safety-B

2013
Identifying drug-related disorders: a probabilistic approach.
    Prescrire international, 2013, Volume: 22, Issue:144

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Probability

2013
Benfluorex: left heart valve disease very common.
    Prescrire international, 2014, Volume: 23, Issue:149

    Topics: Appetite Depressants; Echocardiography; Fenfluramine; France; Heart Valve Diseases; Humans

2014
Food and Drug Administration criteria for the diagnosis of drug-induced valvular heart disease in patients previously exposed to benfluorex: a prospective multicentre study.
    European heart journal. Cardiovascular Imaging, 2015, Volume: 16, Issue:2

    Topics: Aged; Appetite Depressants; Case-Control Studies; Echocardiography, Doppler; Female; Fenfluramine; H

2015
Calcifications in benfluorex-induced valve heart disease: a misknown association.
    Cardiology, 2015, Volume: 130, Issue:2

    Topics: Aged; Aortic Valve Insufficiency; Appetite Depressants; Calcinosis; Fenfluramine; Heart Valve Diseas

2015
Drug-Induced- or Rheumatic- Valvular Heart Disease in Patients Exposed to Benfluorex?
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Aged; Appetite Depressants; Female; Fenfluramine; France; Heart Valve Diseases; Humans; Male; Markov

2016
Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report.
    Medicine, 2017, Volume: 96, Issue:2

    Topics: Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Heart Valve Diseases; Heart Valve Prosthe

2017
Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals.
    BMC medicine, 2008, Nov-06, Volume: 6

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Obesity Agents; Echocardiography; Female; Fenflura

2008
Fenfluramine-like cardiovascular side-effects of benfluorex.
    The European respiratory journal, 2009, Volume: 33, Issue:3

    Topics: Appetite Depressants; Cardiovascular Diseases; Diabetes Mellitus; Female; Fenfluramine; Heart Valve

2009
Benfluorex: negative data in France, but still on the market. Neuropsychiatric disorders, pulmonary hypertension and heart valve damage.
    Prescrire international, 2009, Volume: 18, Issue:101

    Topics: Appetite Depressants; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; N

2009
Fenfluramine disrupts the mitral valve interstitial cell response to serotonin.
    The American journal of pathology, 2009, Volume: 175, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Animals; Cell Proliferation; Cells, Cultured; Dogs; Dose-Response Re

2009
Benfluorex and unexplained valvular heart disease: a case-control study.
    PloS one, 2010, Apr-12, Volume: 5, Issue:4

    Topics: Aged; Case-Control Studies; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents

2010
Benfluorex: increasing reports of valve disorders.
    Prescrire international, 2010, Volume: 19, Issue:105

    Topics: Appetite Depressants; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; P

2010
Valvular heart disease associated with benfluorex.
    Archives of cardiovascular diseases, 2010, Volume: 103, Issue:5

    Topics: Appetite Depressants; Diuretics; Echocardiography, Doppler, Color; Female; Fenfluramine; Furosemide;

2010
Benfluorex: yet more valve disorders.
    Prescrire international, 2010, Volume: 19, Issue:107

    Topics: Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents

2010
Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus.
    Pharmacoepidemiology and drug safety, 2010, Volume: 19, Issue:12

    Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Databases, Factual; D

2010
Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.
    Journal of medicinal chemistry, 2010, Nov-11, Volume: 53, Issue:21

    Topics: Algorithms; Binding, Competitive; Databases, Factual; Dexfenfluramine; Drug-Related Side Effects and

2010
Benfluorex: the last chapter of drug-induced valvular heart disease?
    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2011, Volume: 12, Issue:4

    Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Appetite Depressants; Europe; Fenfluramine; France;

2011
Valvular heart disease associated with benfluorex therapy: results from the French multicentre registry.
    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2011, Volume: 12, Issue:4

    Topics: Appetite Depressants; Body Mass Index; Comorbidity; Dose-Response Relationship, Drug; Echocardiograp

2011
Mediator scandal rocks French medical community.
    Lancet (London, England), 2011, Mar-12, Volume: 377, Issue:9769

    Topics: Appetite Depressants; Drug Industry; Fenfluramine; France; Heart Valve Diseases; Humans; Hypolipidem

2011
[What were the indications for the Mediator in 1979?].
    Revue medicale suisse, 2011, Feb-09, Volume: 7, Issue:281

    Topics: Anxiety; Appetite Depressants; Diabetes Mellitus, Type 2; Fenfluramine; France; Heart Valve Diseases

2011
Benfluorex: how many deaths?
    Prescrire international, 2011, Volume: 20, Issue:113

    Topics: Appetite Depressants; Familial Primary Pulmonary Hypertension; Fenfluramine; France; Heart Valve Dis

2011
Mitral and aortic valvular disease associated with benfluorex use.
    The Journal of heart valve disease, 2011, Volume: 20, Issue:3

    Topics: Aortic Valve; Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Heart Valve Diseases; Human

2011
[The French are wary of their drugs].
    Revue medicale suisse, 2011, May-25, Volume: 7, Issue:296

    Topics: Appetite Depressants; Body Mass Index; Cause of Death; Drugs, Generic; Fenfluramine; France; Heart V

2011
Valvular heart disease associated with benfluorex therapy: high prevalence in patients with unexplained restrictive valvular heart disease.
    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2011, Volume: 12, Issue:9

    Topics: Aortic Valve; Appetite Depressants; Echocardiography, Doppler; Female; Fenfluramine; Heart Valve Dis

2011
Valvular heart disease with the use of fenfluramine-phentermine.
    Texas Heart Institute journal, 2011, Volume: 38, Issue:5

    Topics: Anti-Obesity Agents; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramine; Gast

2011
Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
    Pharmacoepidemiology and drug safety, 2012, Volume: 21, Issue:4

    Topics: Adult; Aged; Appetite Depressants; Cohort Studies; Databases, Factual; Female; Fenfluramine; France;

2012
Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:2

    Topics: Adult; Aortic Valve; Bioprosthesis; Cicatrix, Hypertrophic; Female; Fenfluramine; Fibrosis; Heart Va

2012
Appetite suppressant was probably responsible for 1300 deaths, study shows.
    BMJ (Clinical research ed.), 2012, Feb-09, Volume: 344

    Topics: Appetite Depressants; Drug Industry; Drug-Related Side Effects and Adverse Reactions; Fenfluramine;

2012
Re: Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
    Pharmacoepidemiology and drug safety, 2012, Volume: 21, Issue:6

    Topics: Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Hospitalization; Humans; Male

2012
European legislators tighten rules on drug safety.
    BMJ (Clinical research ed.), 2012, Sep-18, Volume: 345

    Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Diabetes Mellitus, Type 2; Europe; Fe

2012
Benfluorex-induced cardiac valve injury.
    Pharmacoepidemiology and drug safety, 2012, Volume: 21, Issue:11

    Topics: Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Hospitalization; Humans; Male

2012
Fen-Phen-noumenon: A mass tort litigation and settlement about to come and go.
    Journal of the National Medical Association, 2002, Volume: 94, Issue:8 Suppl 2

    Topics: Appetite Depressants; Central Nervous System Stimulants; Fenfluramine; Heart Valve Diseases; Humans;

2002
Morphology of anorexigen-associated valve disease by transthoracic and transesophageal echocardiography.
    The American journal of cardiology, 2002, Dec-01, Volume: 90, Issue:11

    Topics: Adult; Aortic Valve; Appetite Depressants; Body Mass Index; Dexfenfluramine; Drug Combinations; Echo

2002
[Valvular heart disease associated with benfluorex].
    Revista espanola de cardiologia, 2003, Volume: 56, Issue:2

    Topics: Appetite Depressants; Female; Fenfluramine; Fibrosis; Heart Valve Diseases; Heart Valve Prosthesis I

2003
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
    Molecular pharmacology, 2003, Volume: 63, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Cell Division; Cells, Cultured; COS Cells; Fenfluramine; Hea

2003
Do these doctors give medicine a black eye?
    Medical economics, 2003, Volume: 80, Issue:24

    Topics: Appetite Depressants; Compensation and Redress; Drug Industry; Electrocardiography; Expert Testimony

2003
Taking things to heart.
    Journal of the American Dietetic Association, 2004, Volume: 104, Issue:7

    Topics: Appetite Depressants; Dexfenfluramine; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans

2004
Comparison of combinations of drugs for treatment of obesity: body weight and echocardiographic status.
    International journal of obesity (2005), 2007, Volume: 31, Issue:5

    Topics: Adult; Appetite Depressants; Body Mass Index; Drug Therapy, Combination; Fenfluramine; Fluoxetine; H

2007
Valvular heart disease associated with fenfluramine detected 7 years after discontinuation of treatment.
    The Annals of thoracic surgery, 2007, Volume: 83, Issue:4

    Topics: Adult; Aortic Valve; Biopsy, Needle; Dose-Response Relationship, Drug; Drug Administration Schedule;

2007
From the Food and Drug Administration.
    JAMA, 1997, Aug-06, Volume: 278, Issue:5

    Topics: Appetite Depressants; Diabetes Mellitus; Emergency Medical Services; Fenfluramine; Heart Valve Disea

1997
Report links appetite suppressants with heart disease. FDA encourages reporting of like events.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1997, Aug-15, Volume: 54, Issue:16

    Topics: Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Obesity

1997
Valvular heart disease associated with fenfluramine-phentermine.
    The New England journal of medicine, 1997, Aug-28, Volume: 337, Issue:9

    Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Drug Combinations; Female; Fenfluramine; He

1997
Diet pills redux.
    The New England journal of medicine, 1997, Aug-28, Volume: 337, Issue:9

    Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte

1997
Further cases of valvular heart disease associated with fenfluramine-phentermine.
    The New England journal of medicine, 1997, Aug-28, Volume: 337, Issue:9

    Topics: Adult; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans;

1997
Valvular heart disease associated with dexfenfluramine.
    The New England journal of medicine, 1997, Aug-28, Volume: 337, Issue:9

    Topics: Adult; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans; Mitral Valve Insuff

1997
A dangerous duo? A combination of common diet drugs (fen-phen) may lead to heart valve disease.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1997, Sep-15, Volume: 157, Issue:6

    Topics: Appetite Depressants; Drug Combinations; Drug Synergism; Female; Fenfluramine; Heart Valve Diseases;

1997
Fen-phen and risk of valvular disease.
    Circulation, 1997, Sep-16, Volume: 96, Issue:6

    Topics: Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Phenter

1997
Thalidomide checks might have saved Redux.
    Nature biotechnology, 1997, Volume: 15, Issue:12

    Topics: Appetite Depressants; Drug Approval; Fenfluramine; Heart Valve Diseases; HIV Wasting Syndrome; Patie

1997
Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: U.S. Department of Health and Human Services interim public health recommendations, November 1997.
    MMWR. Morbidity and mortality weekly report, 1997, Nov-14, Volume: 46, Issue:45

    Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Appetite Depressants; Echocardiography; Female

1997
From the Centers for Disease Control and Prevention. Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: US Department of Health and Human Services interim public health recommendations, November 1997.
    JAMA, 1997, Dec-03, Volume: 278, Issue:21

    Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Echocardiography; Fenfluramine; Heart

1997
Prepublication release of Journal articles.
    The New England journal of medicine, 1997, Dec-11, Volume: 337, Issue:24

    Topics: Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Publishing

1997
US journal finds lower risk from diet pills.
    BMJ (Clinical research ed.), 1997, Nov-22, Volume: 315, Issue:7119

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine

1997
Valvular heart disease associated with fenfluramine-phentermine.
    The New England journal of medicine, 1997, Dec-11, Volume: 337, Issue:24

    Topics: Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Ultrasonography

1997
Valvular heart disease associated with fenfluramine-phentermine.
    The New England journal of medicine, 1997, Dec-11, Volume: 337, Issue:24

    Topics: Appetite Depressants; Diethylpropion; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases;

1997
Valvular heart disease associated with fenfluramine-phentermine.
    The New England journal of medicine, 1997, Dec-11, Volume: 337, Issue:24

    Topics: Appetite Depressants; Diabetes Mellitus, Type 2; Drug Combinations; Female; Fenfluramine; Heart Valv

1997
Valvular heart disease associated with fenfluramine-phentermine.
    The New England journal of medicine, 1997, Dec-11, Volume: 337, Issue:24

    Topics: Animals; Appetite Depressants; Drug Evaluation, Preclinical; Fenfluramine; Heart Valve Diseases; Hum

1997
Valvular heart disease associated with fenfluramine-phentermine.
    The New England journal of medicine, 1997, Dec-11, Volume: 337, Issue:24

    Topics: Appetite Depressants; Bias; Drug and Narcotic Control; Drug Combinations; Female; Fenfluramine; Hear

1997
Asymptomatic mitral and aortic valve disease is seen in half of the patients taking 'phen-fen'.
    Archives of internal medicine, 1998, Jan-12, Volume: 158, Issue:1

    Topics: Aortic Valve; Appetite Depressants; Echocardiography, Doppler, Color; Fenfluramine; Heart Valve Dise

1998
The treatment of obesity with drugs.
    The American journal of clinical nutrition, 1998, Volume: 67, Issue:1

    Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte

1998
[Drug-clinics. The hue and cry over central appetite suppressants!].
    Revue medicale de Liege, 1997, Volume: 52, Issue:9

    Topics: Adrenergic Agents; Adult; Amphetamines; Appetite; Appetite Depressants; Female; Fenfluramine; Heart

1997
Serotonin: it's possible to have too much of a good thing.
    The Journal of clinical psychiatry, 1997, Volume: 58, Issue:12

    Topics: Bulimia; Depressive Disorder; Fenfluramine; Heart Valve Diseases; Humans; Obsessive-Compulsive Disor

1997
Mitral valve disease associated with use of anorexigenic medications.
    The Annals of thoracic surgery, 1998, Volume: 65, Issue:1

    Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte

1998
Anorectic drugs and valvular heart disease: a biological and clinical perspective.
    Cleveland Clinic journal of medicine, 1998, Volume: 65, Issue:1

    Topics: Adult; Appetite Depressants; Echocardiography; Female; Fenfluramine; Heart Valve Diseases; Humans; M

1998
Valve disease and diet pills--where do we stand?
    American family physician, 1998, Feb-15, Volume: 57, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Appetite Depressants; Dopamine Agents; Drug Therapy, Combination; Ec

1998
Guidelines for users of diet pills.
    Harvard heart letter : from Harvard Medical School, 1998, Volume: 8, Issue:8

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine

1998
Phen-fen fallout. Financial side effects.
    Hospitals & health networks, 1998, Feb-20, Volume: 72, Issue:4

    Topics: Appetite Depressants; Echocardiography; Fenfluramine; Health Maintenance Organizations; Heart Valve

1998
Fen-phen's message to dentists.
    Journal of the New Jersey Dental Association, 1998,Winter, Volume: 69, Issue:1

    Topics: Appetite Depressants; Dental Care for Chronically Ill; Drug Combinations; Fenfluramine; Heart Valve

1998
Anorectic drugs and valvular heart disease.
    Cleveland Clinic journal of medicine, 1998, Volume: 65, Issue:5

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Serotonin

1998
Anorectic drugs and valvular heart disease.
    Cleveland Clinic journal of medicine, 1998, Volume: 65, Issue:5

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans

1998
Valve disease associated with chronic intake of fenfluramines.
    The Journal of laboratory and clinical medicine, 1998, Volume: 131, Issue:5

    Topics: Adult; Aortic Valve; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans; Middl

1998
The "phen-pro" diet drug combination is not associated with valvular heart disease.
    Archives of internal medicine, 1998, Jun-08, Volume: 158, Issue:11

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Mitral Valve; Phentermine

1998
Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998.
    American heart journal, 1998, Volume: 136, Issue:1

    Topics: Aged; Anti-Arrhythmia Agents; Anticholesteremic Agents; Appetite Depressants; Clinical Trials as Top

1998
The fen-phen finale: a study of weight loss and valvular heart disease.
    Obesity research, 1998, Volume: 6, Issue:4

    Topics: Adult; Affect; Appetite; Behavior Therapy; Drug Therapy, Combination; Echocardiography, Doppler; Fem

1998
Anesthesia risks in patients who have had antiobesity medication.
    Plastic and reconstructive surgery, 1998, Volume: 102, Issue:3

    Topics: Anesthesia, General; Appetite Depressants; Contraindications; Fenfluramine; Heart Valve Diseases; Hu

1998
Appetite suppressants and valvular heart disease.
    The New England journal of medicine, 1998, Sep-10, Volume: 339, Issue:11

    Topics: Appetite Depressants; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phente

1998
Regression of multivalvular regurgitation after the cessation of fenfluramine and phentermine treatment.
    The New England journal of medicine, 1998, Sep-10, Volume: 339, Issue:11

    Topics: Adult; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans;

1998
Risks of heart-valve abnormalities with appetite suppressants.
    Lancet (London, England), 1998, Oct-31, Volume: 352, Issue:9138

    Topics: Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Risk Fact

1998
[Pulmonary hypertension and heart valve diseases induced by fenfluramine? Hypothesis or certitude? Myth or reality?].
    La Revue de medecine interne, 1998, Volume: 19, Issue:10

    Topics: Animals; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; He

1998
Former Fen-Phen users may need prophylactic antibiotic before treatment.
    RDH, 1998, Volume: 18, Issue:7

    Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Drug Combinations; En

1998
Risk for valvular heart disease among users of fenfluramine and dexfenfluramine who underwent echocardiography before use of medication.
    Annals of internal medicine, 1998, 12-01, Volume: 129, Issue:11 Pt 1

    Topics: Adult; Appetite Depressants; Cohort Studies; Dexfenfluramine; Disease Progression; Echocardiography;

1998
Diet-drug debacle.
    Annals of internal medicine, 1998, Dec-01, Volume: 129, Issue:11

    Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Obesity; United S

1998
Studies confirm link between fen-phen and heart-valve disease.
    Harvard heart letter : from Harvard Medical School, 1998, Volume: 9, Issue:4

    Topics: Appetite Depressants; Cyclobutanes; Dexfenfluramine; Drug Combinations; Fenfluramine; Heart Valve Di

1998
Appetite-suppressant drugs and valvular heart disease.
    The New England journal of medicine, 1999, Feb-11, Volume: 340, Issue:6

    Topics: Appetite Depressants; Data Interpretation, Statistical; Dexfenfluramine; Fenfluramine; Heart Valve D

1999
Appetite-suppressant drugs and valvular heart disease.
    The New England journal of medicine, 1999, Feb-11, Volume: 340, Issue:6

    Topics: Appetite Depressants; Bias; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Od

1999
After fen-phen.
    Newsweek, 1997, Sep-29, Volume: 130, Issue:13

    Topics: Antidepressive Agents, Second-Generation; Appetite Depressants; Consumer Product Safety; Fenfluramin

1997
Severe heart valve disease on appetite suppressants.
    Prescrire international, 1998, Volume: 7, Issue:33

    Topics: Adult; Appetite Depressants; Case-Control Studies; Diethylpropion; Drug Approval; Drug Combinations;

1998
Dose effect of fenfluramine-phentermine in the production of valvular heart disease.
    The Annals of thoracic surgery, 1999, Volume: 67, Issue:4

    Topics: Appetite Depressants; Diseases in Twins; Dose-Response Relationship, Drug; Drug Therapy, Combination

1999
Valvular heart disease in fenfluramine- phentermine-treated patients: a comparison with control patients.
    Obesity research, 1999, Volume: 7, Issue:3

    Topics: Appetite Depressants; Body Mass Index; Diet, Reducing; Drug Combinations; Echocardiography; Female;

1999
Anorectic therapy and valvular heart disease: a reappraisal.
    European heart journal, 1999, Volume: 20, Issue:13

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Obesity; Phentermine

1999
Dose-effect of fenfluramine use on the severity of valvular heart disease among fen-phen patients with valvulopathy.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1999, Volume: 23, Issue:9

    Topics: Adult; Aortic Valve; Appetite Depressants; Dose-Response Relationship, Drug; Drug Combinations; Fema

1999
Detailed examination of fenfluramine-phentermine users with valve abnormalities identified in Fargo, North Dakota.
    The American journal of cardiology, 1999, Aug-01, Volume: 84, Issue:3

    Topics: Adult; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Middl

1999
Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters.
    Obesity research, 1999, Volume: 7, Issue:5

    Topics: Adult; Appetite Depressants; Depression; Eating; Feeding and Eating Disorders; Female; Fenfluramine;

1999
Low prevalence of valvular heart disease in 226 phentermine-fenfluramine protocol subjects prospectively followed for up to 30 months.
    Journal of the American College of Cardiology, 1999, Volume: 34, Issue:4

    Topics: Adult; Appetite Depressants; Echocardiography, Transesophageal; Female; Fenfluramine; Follow-Up Stud

1999
Fen/phen and valvular heart disease: if it sounds too bad to be true, perhaps it isn't.
    Journal of the American College of Cardiology, 1999, Volume: 34, Issue:4

    Topics: Adult; Adverse Drug Reaction Reporting Systems; Appetite Depressants; Echocardiography, Transesophag

1999
[Appetite suppressants and heart valve disorders].
    Archives des maladies du coeur et des vaisseaux, 1999, Volume: 92, Issue:9

    Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine

1999
Prevention of infective endocarditis associated with dental treatment and other medical interventions. National Heart Foundation.
    The New Zealand dental journal, 1999, Volume: 95, Issue:421

    Topics: Adult; Anti-Obesity Agents; Antibiotic Prophylaxis; Aortic Valve Insufficiency; Cefuroxime; Cephalos

1999
[Fenfluramines and cardiac valvular lesions].
    Revue medicale de Bruxelles, 1999, Volume: 20, Issue:5

    Topics: Adult; Aged; Dexfenfluramine; Echocardiography, Doppler; Electrocardiography, Ambulatory; Female; Fe

1999
The fen-phen controversy: is regression another piece of the puzzle?
    Mayo Clinic proceedings, 1999, Volume: 74, Issue:12

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine

1999
Diet drug maker agrees to $3.75 billion settlement.
    Circulation, 1999, Dec-21, Volume: 100, Issue:25

    Topics: Dexfenfluramine; Drug Industry; Fenfluramine; Heart Valve Diseases; Humans; United States

1999
Aminorex to Fen/Phen: an epidemic foretold.
    Circulation, 1999, Dec-21, Volume: 100, Issue:25

    Topics: Aminorex; Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Human

1999
Aminorex to Fen/Phen: an epidemic foretold.
    Circulation, 1999, Dec-21, Volume: 100, Issue:25

    Topics: Aminorex; Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Human

1999
Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
    Molecular pharmacology, 2000, Volume: 57, Issue:1

    Topics: Animals; Appetite Depressants; Cell Line; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans;

2000
The need for greater involvement of regulatory agencies in assessing adverse drug reactions.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2000, Jan-25, Volume: 162, Issue:2

    Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Drug Industry; Fenfluramine; Governme

2000
Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine.
    JAMA, 2000, Apr-05, Volume: 283, Issue:13

    Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Dexfenfluramine; Echocardiography

2000
Heart valve disorders and appetite-suppressant drugs.
    JAMA, 2000, Apr-05, Volume: 283, Issue:13

    Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Sero

2000
Anorectic-induced valvulopathy.
    European heart journal, 2000, Volume: 21, Issue:7

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine; Time Factors

2000
Was the danger of diet pills overstated?
    Harvard heart letter : from Harvard Medical School, 2000, Volume: 10, Issue:6

    Topics: Appetite Depressants; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phente

2000
Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience.
    Mayo Clinic proceedings, 2000, Volume: 75, Issue:5

    Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans

2000
Fen-phen manufacturers, not physicians, are liable.
    Texas medicine, 2000, Volume: 96, Issue:5

    Topics: Appetite Depressants; Drug Combinations; Drug Industry; Fenfluramine; Heart Valve Diseases; Humans;

2000
More on heart disease and diet pills.
    Harvard heart letter : from Harvard Medical School, 2000, Volume: 10, Issue:11

    Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Serotonin Agents

2000
[Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants].
    Harefuah, 1998, Dec-01, Volume: 135, Issue:11

    Topics: Aged; Appetite Depressants; Drug Therapy, Combination; Female; Fenfluramine; Heart Valve Diseases; H

1998
Cardiac valvulopathy.
    Journal of the American Dental Association (1939), 2000, Volume: 131, Issue:7

    Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care; Dexfenfluramine; Fenfluramine; Heart Valv

2000
Lessons from the fenfluramines: antiobesity medications are frequently misused.
    The Annals of pharmacotherapy, 2000, Volume: 34, Issue:3

    Topics: Anti-Obesity Agents; Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Substance-Rel

2000
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.
    Circulation, 2000, Dec-05, Volume: 102, Issue:23

    Topics: Dose-Response Relationship, Drug; Ergotamine; Fenfluramine; Heart Valve Diseases; Humans; Methylergo

2000
Diet drugs and cardiac valvulopathy: a survey of dental patients.
    Journal of the California Dental Association, 2000, Volume: 28, Issue:12

    Topics: Adult; Antibiotic Prophylaxis; Appetite Depressants; Dental Care; Dexfenfluramine; Endocarditis, Bac

2000
By the way, doctor...I used a diet pill--fenfluramine--a few years ago, but stopped as soon as I heard about it causing heart-valve problems. My doctor has been doing echocardiograms on me every six months. So far, everything looks good. How long do you t
    Harvard health letter, 2001, Volume: 26, Issue:7

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Time Factors; Ultrasonography

2001
Valve disease due to appetite suppressants (cont'd).
    Prescrire international, 1999, Volume: 8, Issue:42

    Topics: Aortic Valve; Appetite Depressants; Clinical Trials as Topic; Dexfenfluramine; Fenfluramine; Heart V

1999
Operation for anorexigen-associated valvular heart disease.
    The Journal of thoracic and cardiovascular surgery, 2001, Volume: 122, Issue:4

    Topics: Adult; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Mi

2001
Reversal of Phen-Fen associated valvular regurgitation documented by serial echocardiography.
    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2002, Volume: 15, Issue:6

    Topics: Appetite Depressants; Echocardiography; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle A

2002