fenfluramine has been researched along with Heart Failure in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine is a widely prescribed anorectic drug as adjuvant therapy for obesity." | 7.68 | Pulmonary hypertension and fenfluramine. ( Cheriex, EC; Pouwels, HM; Smeets, JL; Wouters, EF, 1990) |
| "Fenfluramine is a widely prescribed anorectic drug as adjuvant therapy for obesity." | 3.68 | Pulmonary hypertension and fenfluramine. ( Cheriex, EC; Pouwels, HM; Smeets, JL; Wouters, EF, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fowles, RE | 1 |
| Cloward, TV | 1 |
| Yowell, RL | 1 |
| Pouwels, HM | 1 |
| Smeets, JL | 1 |
| Cheriex, EC | 1 |
| Wouters, EF | 1 |
2 other studies available for fenfluramine and Heart Failure
| Article | Year |
|---|---|
Endocardial fibrosis associated with fenfluramine-phentermine.
Topics: Adult; Appetite Depressants; Drug Therapy, Combination; Endomyocardial Fibrosis; Female; Fenfluramin | 1998 |
Pulmonary hypertension and fenfluramine.
Topics: Female; Fenfluramine; Heart Failure; Humans; Hypertension, Pulmonary; Middle Aged; Obesity | 1990 |